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G-Valve

Unraveling the mechanobiology of tissue growth in native and tissue-engineered heart valves

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "G-Valve" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.tue.nl/universiteit/faculteiten/biomedische-technologie/onderzoek/onderzoeksgroepen-biomedische-technologie/soft-tissue-biomechanics-engineering/research/research-projects/unraveling-the-m
 Total cost 174˙864 €
 EC max contribution 174˙864 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-08-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 174˙864.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

The currently available heart valve prostheses do not consist of living tissue and, hence, they cannot grow, repair, and remodel in response to changing demands. This restricts the use of valve replacements in pediatric patients, since they need multiple reoperations to accommodate somatic growth. Tissue-engineered heart valves (TEHVs) may be able to overcome this limitation due to their growth and remodeling potential. However, the exact growth and remodeling processes remain poorly understood, which has become evident in many pre-clinical studies where TEHVs lost their functionality over time due to adverse tissue remodeling. The goal of this proposal is to unravel the mechanisms of tissue growth in native valves and TEHVs by integrating advanced continuum mechanics and cell biology, in order to develop predictive models of valve growth that can guide and optimize tissue engineering of heart valves. To achieve this goal, I will first be trained in developing continuum models of valve growth in the lab of Dr. Kuhl at Stanford University, who is a leading expert in modeling soft tissue growth. Furthermore, I will be trained in cell biology and mechanobiology which will enable me to develop agent-based mechanobiological models as a driving mechanism for valve growth in the continuum models. I will use the obtained knowledge to analyze and predict growth of TEHVs in Europe. At this moment, mechanistic models of valve growth are not available. The models that I will develop during and after my training will provide crucial information for designing TEHVs with long-term functionality and growth potential, and will boost European excellence and competitiveness in the fields of biomechanics and tissue engineering. Moreover, the training that I will receive will significantly extend my scientific profile, and it will provide me the valuable international training at a prestigious academic institute that is required for pursuing an academic career in Europe.

 Publications

year authors and title journal last update
List of publications.
2018 Pim J. A. Oomen, Maria A. Holland, Carlijn V. C. Bouten, Ellen Kuhl, Sandra Loerakker
Growth and remodeling play opposing roles during postnatal human heart valve development
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-19777-1
Scientific Reports 8/1 2019-04-14
2018 Sandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, Cecilia M. Sahlgren
Mechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasis
published pages: E3682-E3691, ISSN: 0027-8424, DOI: 10.1073/pnas.1715277115
Proceedings of the National Academy of Sciences 115/16 2019-04-14
2018 T. Ristori, C.V.C. Bouten, F.P.T. Baaijens, S. Loerakker
Predicting and understanding collagen remodeling in human native heart valves during early development
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.08.040
Acta Biomaterialia 2019-04-14
2016 P.J.A. Oomen, S. Loerakker, D. van Geemen, J. Neggers, M.-J.T.H. Goumans, A.J. van den Bogaerdt, A.J.J.C. Bogers, C.V.C. Bouten, F.P.T. Baaijens
Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling
published pages: 161-169, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2015.10.044
Acta Biomaterialia 29 2019-06-13

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The information about "G-VALVE" are provided by the European Opendata Portal: CORDIS opendata.

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