Explore the words cloud of the PhageResist project. It provides you a very rough idea of what is the project "PhageResist" about.
The following table provides information about the project.
WEIZMANN INSTITUTE OF SCIENCE
|Coordinator Country||Israel [IL]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||WEIZMANN INSTITUTE OF SCIENCE||IL (REHOVOT)||coordinator||2˙000˙000.00|
The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been learned on the biology of bacterial defense against phage, more than half of all sequenced bacteria do not contain CRISPR-Cas, and it is estimated that many additional, yet-uncharacterized anti-phage defense systems are encoded in bacterial genomes.
The goal of this project is to systematically understand the arsenal of defense mechanisms that are at the disposal of microbes in their struggle against phages. The project combines computational genomics, synthetic biology, high-throughput robotic assays, and deep genetic and biochemical experiments to discover, verify, and study the properties of anti-phage defense systems.
|year||authors and title||journal||last update|
Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai, Rotem Sorek
Communication between viruses guides lysisâ€“lysogeny decisions
published pages: 488-493, ISSN: 0028-0836, DOI: 10.1038/nature21049
Shany Doron, Sarah Melamed, Gal Ofir, Azita Leavitt, Anna Lopatina, Mai Keren, Gil Amitai, Rotem Sorek
Systematic discovery of antiphage defense systems in the microbial pangenome
published pages: eaar4120, ISSN: 0036-8075, DOI: 10.1126/science.aar4120
MÃ©lodie Duval, Daniel Dar, Filipe Carvalho, Eduardo P. C. Rocha, Rotem Sorek, Pascale Cossart
HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance
published pages: 13359-13364, ISSN: 0027-8424, DOI: 10.1073/pnas.1810555115
|Proceedings of the National Academy of Sciences 115/52||2019-06-05|
Dar, Daniel; Sorek, Rotem
High-resolution RNA 3â€²-ends mapping of bacterial Rho-dependent transcripts
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky274
|Nucleic Acids Research 1||2019-06-05|
Daniel Dar, Rotem Sorek
Extensive reshaping of bacterial operons by programmed mRNA decay
published pages: e1007354, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007354
|PLOS Genetics 14/4||2019-06-05|
MoranÂ G. Goren, Shany Doron, Rea Globus, Gil Amitai, Rotem Sorek, Udi Qimron
Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array
published pages: 2811-2818, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.08.043
|Cell Reports 16/11||2019-06-05|
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