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PhageResist SIGNED

Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome

Total Cost €


EC-Contrib. €






Project "PhageResist" data sheet

The following table provides information about the project.


Organization address
address: HERZL STREET 234
postcode: 7610001

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 2˙000˙000.00


 Project objective

The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been learned on the biology of bacterial defense against phage, more than half of all sequenced bacteria do not contain CRISPR-Cas, and it is estimated that many additional, yet-uncharacterized anti-phage defense systems are encoded in bacterial genomes.

The goal of this project is to systematically understand the arsenal of defense mechanisms that are at the disposal of microbes in their struggle against phages. The project combines computational genomics, synthetic biology, high-throughput robotic assays, and deep genetic and biochemical experiments to discover, verify, and study the properties of anti-phage defense systems.


year authors and title journal last update
List of publications.
2017 Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai, Rotem Sorek
Communication between viruses guides lysis–lysogeny decisions
published pages: 488-493, ISSN: 0028-0836, DOI: 10.1038/nature21049
Nature 541/7638 2019-06-18
2018 Shany Doron, Sarah Melamed, Gal Ofir, Azita Leavitt, Anna Lopatina, Mai Keren, Gil Amitai, Rotem Sorek
Systematic discovery of antiphage defense systems in the microbial pangenome
published pages: eaar4120, ISSN: 0036-8075, DOI: 10.1126/science.aar4120
Science 359/6379 2019-06-05
2018 Mélodie Duval, Daniel Dar, Filipe Carvalho, Eduardo P. C. Rocha, Rotem Sorek, Pascale Cossart
HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance
published pages: 13359-13364, ISSN: 0027-8424, DOI: 10.1073/pnas.1810555115
Proceedings of the National Academy of Sciences 115/52 2019-06-05
2018 Dar, Daniel; Sorek, Rotem
High-resolution RNA 3′-ends mapping of bacterial Rho-dependent transcripts
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky274
Nucleic Acids Research 1 2019-06-05
2018 Daniel Dar, Rotem Sorek
Extensive reshaping of bacterial operons by programmed mRNA decay
published pages: e1007354, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007354
PLOS Genetics 14/4 2019-06-05
2016 Moran G. Goren, Shany Doron, Rea Globus, Gil Amitai, Rotem Sorek, Udi Qimron
Repeat Size Determination by Two Molecular Rulers in the Type I-E CRISPR Array
published pages: 2811-2818, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.08.043
Cell Reports 16/11 2019-06-05

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