Explore the words cloud of the LIPID IMMUNITY project. It provides you a very rough idea of what is the project "LIPID IMMUNITY" about.
The following table provides information about the project.
KING'S COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-03-01 to 2018-02-28|
Take a look of project's partnership.
|1||KING'S COLLEGE LONDON||UK (LONDON)||coordinator||195˙454.00|
The gastrointestinal tract is continuously exposed to multiple antigens from commensal bacteria, food and pathogens. The mechanisms by which the gut mucosa tolerates trillions of commensal bacteria without developing inflammation remains poorly understood. It is increasingly appreciated that commensal bacteria-derived products regulate the homeostasis and/or function of many immune cell populations. Commensal bacteria-derived lipids are recognized by a population of unconventional T cells, called NKT cells. NKT cells specifically recognize through their T cell receptor lipid antigens presented by the MHC-I-like molecule CD1 which is expressed by a variety of immune cells within the intestinal tissue. Importantly, commensal-derived lipids modulate the numbers, phenotype and function of intestinal NKT cells. Conversely, dysregulation of NKT cell activation and/or CD1 expression have been associated with the development of colitis in mice and humans. Despite the abundance and diversity of microbial-derived lipids present in the gut, the molecular and cellular mechanisms that mediate their recognition by immune cells and the identity of the antigen presenting cells involved in this process remain unknown. By using a combination of multiparametric flow cytometry, genetic engineering and in vivo experiments this proposal aims to unravel the mechanisms and functional consequences of lipid-presentation in the mucosa. These studies will provide a better understanding of the factors that modulate intestinal immunity, with the potential to improve therapies for patients suffering from intestinal inflammatory diseases and possibly a broader range of disorders.
|year||authors and title||journal||last update|
Julia SÃ¡ez de Guinoa, Rebeca Jimeno, Mauro Gaya, David Kipling, MarÃa JosÃ© GarzÃ³n, Deborah Dunnâ€Walters, Carles Ubeda, Patricia Barral
CD1dâ€mediated lipid presentation by CD11c + cells regulates intestinal homeostasis
published pages: e97537, ISSN: 0261-4189, DOI: 10.15252/embj.201797537
|The EMBO Journal 37/5||2019-06-13|
Julia Saez de Guinoa, Rebeca Jimeno, Nazanin Farhadi, Peter J Jervis, Liam R Cox, Gurdyal S Besra, Patricia Barral
CD1dâ€mediated activation of group 3 innate lymphoid cells drives ILâ€22 production
published pages: e201642412, ISSN: 1469-221X, DOI: 10.15252/embr.201642412
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LIPID IMMUNITY" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "LIPID IMMUNITY" are provided by the European Opendata Portal: CORDIS opendata.