Explore the words cloud of the SmartCubes project. It provides you a very rough idea of what is the project "SmartCubes" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||185˙857 €|
|EC max contribution||185˙857 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-06-01 to 2019-03-20|
Take a look of project's partnership.
|1||KAROLINSKA INSTITUTET||SE (STOCKHOLM)||coordinator||185˙857.00|
'SmartCubes' are an innovative class of nanoparticles for the targeted delivery of protein therapeutics. The objective is to deliver high levels of membrane proteins to cancer cells to combat disease. I will achieve this by creating novel 'sponge-like' targeted nanoparticles (SmartCubes) to selectively deliver unprecedented levels of a cancer therapeutic protein to colon adenocarcinoma cells.
‘SmartCubes’ are based on a cubic membrane structure. They contain a highly stable lipid bilayer displaying a 'honeycomb-like' construction. This structure has prevented previous applications as the water channels were too small for large proteins to enter and reconstitute into the membrane. I am uniquely able to tune the sizes of the water channels within the 'SmartCubes' to create water networks sufficiently large to house a whole new class of proteins. I will achieve this new class of nanoparticles by creating 'SmartCubes', modifying the outer surface of the 'SmartCubes' with a selective antibody, loading the cubic membrane with a cancer therapeutic protein and delivering them to cancer cells.
Protein therapeutics are an exciting alternative to conventional cancer treatments due to reduced side effects and their high target selectivity. I can surpass previous attempts which were limited by rapid protein degradation and the instability of the delivery vehicle. As protein therapeutics increase in complexity, there is a need for stable, high surface area, membrane based delivery systems. This project, hosted in the 2014 European life sciences group of the year, will transform my fundamental research into a platform technology that will revolutionise the field of protein therapeutics.
|year||authors and title||journal||last update|
Hanna M. G. Barriga, Margaret N. Holme, Molly M. Stevens
Cubosomes: The Next Generation of Smart Lipid Nanoparticles?
published pages: 2958-2978, ISSN: 1433-7851, DOI: 10.1002/anie.201804067
|Angewandte Chemie International Edition 58/10||2019-09-04|
Margaret N. Holme, M. Harunur Rashid, Michael R. Thomas, Hanna M. G. Barriga, Karlaâˆ’Luise Herpoldt, Richard K. Heenan, CÃ©cile A. Dreiss, JosÃ© Leobardo BaÃ±uelos, Hai-nan Xie, Irene Yarovsky, Molly M. Stevens
Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement
published pages: 1023-1030, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00286
|ACS Central Science 4/8||2019-09-04|
Margaret N. Holme, Subinoy Rana, Hanna M. G. Barriga, Ulrike Kauscher, Nicholas J. Brooks, Molly M. Stevens
A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors
published pages: 8197-8207, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b03308
|ACS Nano 12/8||2019-09-04|
Joanna L. Richens, Arwen I. I. Tyler, Hanna M. G. Barriga, Jonathan P. Bramble, Robert V. Law, Nicholas J. Brooks, John M. Seddon, Oscar Ces, Paul Oâ€™Shea
Spontaneous charged lipid transfer between lipid vesicles
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12611-0
|Scientific Reports 7/1||2019-09-04|
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The information about "SMARTCUBES" are provided by the European Opendata Portal: CORDIS opendata.
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