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SmartCubes SIGNED

An innovative class of nanoparticles (“SmartCubes”) for the targeted delivery of protein therapeutics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SmartCubes" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.stevensgroup.org/index.php/people
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2019-03-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 185˙857.00

Map

 Project objective

'SmartCubes' are an innovative class of nanoparticles for the targeted delivery of protein therapeutics. The objective is to deliver high levels of membrane proteins to cancer cells to combat disease. I will achieve this by creating novel 'sponge-like' targeted nanoparticles (SmartCubes) to selectively deliver unprecedented levels of a cancer therapeutic protein to colon adenocarcinoma cells.

‘SmartCubes’ are based on a cubic membrane structure. They contain a highly stable lipid bilayer displaying a 'honeycomb-like' construction. This structure has prevented previous applications as the water channels were too small for large proteins to enter and reconstitute into the membrane. I am uniquely able to tune the sizes of the water channels within the 'SmartCubes' to create water networks sufficiently large to house a whole new class of proteins. I will achieve this new class of nanoparticles by creating 'SmartCubes', modifying the outer surface of the 'SmartCubes' with a selective antibody, loading the cubic membrane with a cancer therapeutic protein and delivering them to cancer cells.

Protein therapeutics are an exciting alternative to conventional cancer treatments due to reduced side effects and their high target selectivity. I can surpass previous attempts which were limited by rapid protein degradation and the instability of the delivery vehicle. As protein therapeutics increase in complexity, there is a need for stable, high surface area, membrane based delivery systems. This project, hosted in the 2014 European life sciences group of the year, will transform my fundamental research into a platform technology that will revolutionise the field of protein therapeutics.

 Publications

year authors and title journal last update
List of publications.
2019 Hanna M. G. Barriga, Margaret N. Holme, Molly M. Stevens
Cubosomes: The Next Generation of Smart Lipid Nanoparticles?
published pages: 2958-2978, ISSN: 1433-7851, DOI: 10.1002/anie.201804067
Angewandte Chemie International Edition 58/10 2019-09-04
2018 Margaret N. Holme, M. Harunur Rashid, Michael R. Thomas, Hanna M. G. Barriga, Karla−Luise Herpoldt, Richard K. Heenan, Cécile A. Dreiss, José Leobardo Bañuelos, Hai-nan Xie, Irene Yarovsky, Molly M. Stevens
Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement
published pages: 1023-1030, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00286
ACS Central Science 4/8 2019-09-04
2018 Margaret N. Holme, Subinoy Rana, Hanna M. G. Barriga, Ulrike Kauscher, Nicholas J. Brooks, Molly M. Stevens
A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors
published pages: 8197-8207, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b03308
ACS Nano 12/8 2019-09-04
2017 Joanna L. Richens, Arwen I. I. Tyler, Hanna M. G. Barriga, Jonathan P. Bramble, Robert V. Law, Nicholas J. Brooks, John M. Seddon, Oscar Ces, Paul O’Shea
Spontaneous charged lipid transfer between lipid vesicles
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12611-0
Scientific Reports 7/1 2019-09-04

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The information about "SMARTCUBES" are provided by the European Opendata Portal: CORDIS opendata.

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