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A Computational Framework For Quantitative Modeling of Leaf Development in Arabidopsis and Cardamine

Total Cost €


EC-Contrib. €






 CFQMLD project word cloud

Explore the words cloud of the CFQMLD project. It provides you a very rough idea of what is the project "CFQMLD" about.

chain    proposes    falling    model    underlying    regulation    leafed    training    systematic    insights    lab    intersection    efforts    sculpting    interrogation    ideal    gene    leaves    displaying    determinants    compound    thaliana    final    confounded    manner    door    plant    expression    genes    striking    biology    leaf    promise    form    tsiantis    strengths    division    developmental    interface    organization    tissue    forms    emerges    shape    combined    deeply    models    interdisciplinary    close    individual    relation    complexity    elusive    modeling    genetic    mechanistic    molecular    progress    permit    macroscopic    experimental    diversity    fundamental    quantitative    hirsuta    consequently    cell    self    species    exploits    context    computational    remarkable    understanding    organisms    living    science    framework    opens    linking    elucidate    expertise    eukaryotic    interactions    action    vehicle    informed    computer    relative    shapes   

Project "CFQMLD" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Understanding how form emerges in living organisms is a fundamental challenge for biology. Progress, however, has been confounded by the complex chain of interactions underlying the organization of macroscopic forms from molecular processes. Consequently, insights into the manner in which individual genes contribute to the development of form have been elusive; even in well-studied model organisms. In this context, leaves provide a striking example of the self-organization of form – displaying remarkable diversity within and between species. Now, exploiting the close relation between simple leafed A. thaliana and compound leafed C. hirsuta, the Tsiantis lab has identified the key genetic factors underlying their distinct leaf shapes. This opens the door to a detailed understanding of the developmental factors sculpting leaf form.

Due to the complexity of leaf development, however, a mechanistic understanding of these factors requires computational models, informed by detailed quantitative measurements of growth and gene expression. Such models permit the systematic interrogation of the interactions linking genetic regulation, cell division and tissue growth to final form. This action proposes to develop such a computational framework. When combined with experimental efforts, these models promise to help elucidate the regulation of leaf form and provide essential insights into shape regulation in eukaryotic systems. The proposed research is deeply interdisciplinary, working at the interface of computer science and developmental biology. Falling directly at the intersection of the Tsiantis lab's expertise in studying the molecular determinants of leaf form and my expertise in computational modeling of plant development, it fully exploits our relative strengths. Thus providing an ideal vehicle to facilitate essential training while addressing a fundamental research problem.


year authors and title journal last update
List of publications.
2018 Francesco Vuolo, Daniel Kierzkowski, Adam Runions, Mohsen Hajheidari, Remco A. Mentink, Mainak Das Gupta, Zhongjuan Zhang, Daniela Vlad, Yi Wang, Ales Pecinka, Xiangchao Gan, Angela Hay, Peter Huijser, Miltos Tsiantis
LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication
published pages: 1361-1366, ISSN: 0890-9369, DOI: 10.1101/gad.318212.118
Genes & Development 32/21-22 2019-07-26
2019 Aleksandra Sapala, Adam Runions, Richard S Smith
Mechanics, geometry and genetics of epidermal cell shape regulation: different pieces of the same puzzle
published pages: 1-8, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2018.07.017
Current Opinion in Plant Biology 47 2019-07-26
2018 Aleksandra Sapala, Adam Runions, Anne-Lise Routier-Kierzkowska, Mainak Das Gupta, Lilan Hong, Hugo Hofhuis, Stéphane Verger, Gabriella Mosca, Chun-Biu Li, Angela Hay, Olivier Hamant, Adrienne HK Roeder, Miltos Tsiantis, Przemyslaw Prusinkiewicz, Richard S Smith
Why plants make puzzle cells, and how their shape emerges
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.32794
eLife 7 2019-07-26
2017 Adam Runions, Miltos Tsiantis
The shape of things to come: From typology to predictive models for leaf diversity
published pages: 1437-1441, ISSN: 0002-9122, DOI: 10.3732/ajb.1700251
American Journal of Botany 104/10 2019-07-26

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