FUNMETA

Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy

 Coordinatore UNIVERSITA DEGLI STUDI DI PERUGIA 

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 Nazionalità Coordinatore Italy [IT]
 Totale costo 2˙299˙200 €
 EC contributo 2˙299˙200 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2011-ADG_20110310
 Funding Scheme ERC-AG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-04-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE

 Organization address address: Piazza San Marco 4
city: Florence
postcode: 50121

contact info
Titolo: Prof.
Nome: Pierangelo
Cognome: Geppetti
Email: send email
Telefono: +39 055 4271329
Fax: +39 055 4271280

IT (Florence) beneficiary 337˙600.80
2    UNIVERSITA DEGLI STUDI DI PARMA

 Organization address address: VIA UNIVERSITA 12
city: PARMA
postcode: 43100

contact info
Titolo: Prof.
Nome: Antonio
Cognome: Mutti
Email: send email
Telefono: 390521000000
Fax: 390521000000

IT (PARMA) beneficiary 72˙000.00
3    UNIVERSITA DEGLI STUDI DI PERUGIA

 Organization address address: PIAZZA DELL' UNIVERSITA 1
city: PERUGIA
postcode: 6123

contact info
Titolo: Prof.
Nome: Luigina
Cognome: Romani
Email: send email
Telefono: +39 075 5858234
Fax: +39 075 585 8410

IT (PERUGIA) hostInstitution 1˙889˙599.20
4    UNIVERSITA DEGLI STUDI DI PERUGIA

 Organization address address: PIAZZA DELL' UNIVERSITA 1
city: PERUGIA
postcode: 6123

contact info
Titolo: Prof.
Nome: Vincenzo Nicola
Cognome: Talesa
Email: send email
Telefono: +39 075 5858222
Fax: +39 075 5858410

IT (PERUGIA) hostInstitution 1˙889˙599.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

host    metabolic    ido    infections    health    immune    fungi    pathways    symbiotic    pathway    techniques    human    breakdown    trp    fungal    antifungal    diseases   

 Obiettivo del progetto (Objective)

'Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (including fungi) and individual variations in the microbiome influence host health and disease. The fact that fungi are capable of colonizing almost every niche within the human body suggests that they must possess particular immune adaptation mechanisms, the breakdown of which may result in fatal fungal infections and severe fungal diseases. Traditional reductionist approaches of the past have not been sufficient to address these new challenges in the pathogenesis of fungal diseases. Here, I propose an integrated, systems biology approach to understand the role of L-tryptophan (trp) metabolic pathways in multilevel host−fungus interactions. Present in mammals as well as in fungi, pathways of trp metabolic pathways are exploited by the host and the fungal biota for survival and immune adaptation. A variety of indole derivatives, generated through conversion from dietary trp by symbiotic bacteria, activate the aryl hydrocarbon receptor/IL-22 pathway that provides antifungal resistance and tissue repair. Harmful inflammatory responses to fungi are instead tamed by kynurenines generated via the enzyme indoleamine 2,3–dioxygenase (IDO) of the trp pathway. Through high-throughput wet-lab ‘omics’ techniques combined with computational techniques, the project aims at defining the molecular basis of mammalian and fungal IDO activity and a metabolic network linking the metabolic phenotype (metabotype) to immune adaptations and its possible breakdown in experimental and human fungal infections. The project will provide ideal post-graduate training focussed on the development of metabolomics for diagnosis of fungal diseases and optimization of current antifungal therapy and diet that are of relevance to public health care solutions.'

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