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HONEYDIAB-8

Characterization of islet-specific CD8 T cells in the honeymoon of type 1 diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HONEYDIAB-8 project word cloud

Explore the words cloud of the HONEYDIAB-8 project. It provides you a very rough idea of what is the project "HONEYDIAB-8" about.

postulating    usually    type    attack    exogenous    though    oversee    possibilities    insulin    follow    patients    fundamental    collected    metabolic    differentiation    effectors    biomarkers    cross    presumably    originality    honeymoon    suitable    perform    metabolism    effector    poorly    attempt    relate    establishment    identification    first    immunobiology    career    functional    characterization    t1d    optimized    modulation    regeneration    human    producing    diabetes    few    vivo    technological    opportunity    interesting    enzyme    assays    flow    period    reflect    chronic    gene    novelty    islet    involve    disease    re    unknown    langerhans    antigens    immunoassays    self    sectional    quality    final    pursuing    autoimmunity    cells    industry    pancreatic    cd8    exposure    plan    immunotherapies    remission    antigen    decreased    expression    immunological    death    autoimmune    islets    collaborations    cell    memory    highlighting    analysed    tolerance    longitudinal    immunology    unusual    cytometry    beta   

Project "HONEYDIAB-8" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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name: n.a.
surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/diiid/departments/immunobiology/research/peakman/currentresearch
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2019-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Type 1 Diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin-producing β-cells in the pancreatic islets of Langerhans. T1D usually comprises a phase called ‘honeymoon’, an interesting though poorly studied period of the disease where exogenous insulin requirements are decreased, postulating a possible attempt of β-cell regeneration and a remission of the autoimmunity. The proposed research aims to identify and characterize islet-specific CD8 T cells, the final effectors of β-cell death, in the honeymoon of T1D. We plan to perform a cross-sectional and longitudinal study with T1D patients where the immunological and metabolic characterization will be collected during the first year of the disease, and analysed by flow cytometry, enzyme immunoassays, gene expression and functional assays.

The project addresses the characterization of the following unknown immunological features, pursuing a novel concept in T1D field: the role of antigen-specific CD8 T cells in the modulation of autoimmune response in the honeymoon phase. There will be technological and fundamental Immunobiology advances provided by the opportunity to analyse effector cells in these unusual effector memory differentiation states, which presumably reflect chronic exposure to self-antigens. Finally, the highlighting of suitable T-cell related biomarkers for the honeymoon could help in the early identification of the patients with best tolerance re-establishment potential, as well as providing an optimized follow up of future immunotherapies. There are very few studies of key immunology processes as they relate to human metabolism in vivo, and the applicant will learn how to oversee these. The high-quality and originality of the proposed research will open up the best career possibilities for the applicant through and its novelty could also involve industry collaborations.

 Publications

year authors and title journal last update
List of publications.
2018 Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/jci120555
Journal of Clinical Investigation 128/8 2020-02-07

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