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HONEYDIAB-8

Characterization of islet-specific CD8 T cells in the honeymoon of type 1 diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HONEYDIAB-8 project word cloud

Explore the words cloud of the HONEYDIAB-8 project. It provides you a very rough idea of what is the project "HONEYDIAB-8" about.

beta    metabolism    highlighting    period    fundamental    oversee    few    opportunity    tolerance    cell    technological    type    follow    islets    decreased    though    longitudinal    industry    autoimmune    cd8    exogenous    characterization    antigen    novelty    analysed    chronic    cross    final    death    interesting    immunological    differentiation    immunoassays    remission    attempt    modulation    re    first    gene    enzyme    presumably    honeymoon    sectional    exposure    autoimmunity    plan    islet    reflect    biomarkers    postulating    quality    originality    assays    involve    effector    relate    poorly    vivo    insulin    perform    pursuing    immunotherapies    disease    memory    patients    unknown    functional    flow    immunobiology    suitable    effectors    identification    possibilities    pancreatic    attack    langerhans    diabetes    career    human    usually    antigens    t1d    metabolic    collaborations    collected    cytometry    regeneration    optimized    self    producing    cells    unusual    immunology    establishment    expression   

Project "HONEYDIAB-8" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/diiid/departments/immunobiology/research/peakman/currentresearch
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2019-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Type 1 Diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin-producing β-cells in the pancreatic islets of Langerhans. T1D usually comprises a phase called ‘honeymoon’, an interesting though poorly studied period of the disease where exogenous insulin requirements are decreased, postulating a possible attempt of β-cell regeneration and a remission of the autoimmunity. The proposed research aims to identify and characterize islet-specific CD8 T cells, the final effectors of β-cell death, in the honeymoon of T1D. We plan to perform a cross-sectional and longitudinal study with T1D patients where the immunological and metabolic characterization will be collected during the first year of the disease, and analysed by flow cytometry, enzyme immunoassays, gene expression and functional assays.

The project addresses the characterization of the following unknown immunological features, pursuing a novel concept in T1D field: the role of antigen-specific CD8 T cells in the modulation of autoimmune response in the honeymoon phase. There will be technological and fundamental Immunobiology advances provided by the opportunity to analyse effector cells in these unusual effector memory differentiation states, which presumably reflect chronic exposure to self-antigens. Finally, the highlighting of suitable T-cell related biomarkers for the honeymoon could help in the early identification of the patients with best tolerance re-establishment potential, as well as providing an optimized follow up of future immunotherapies. There are very few studies of key immunology processes as they relate to human metabolism in vivo, and the applicant will learn how to oversee these. The high-quality and originality of the proposed research will open up the best career possibilities for the applicant through and its novelty could also involve industry collaborations.

 Publications

year authors and title journal last update
List of publications.
2018 Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/jci120555
Journal of Clinical Investigation 128/8 2020-02-07

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