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ENDYVE SIGNED

ENgineering DYnamic ViscoElasticity to study cell response

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "ENDYVE" data sheet

The following table provides information about the project.

Coordinator
OPTICS11 BV 

Organization address
address: DE BOELELAAN 1081
city: AMSTERDAM
postcode: 1081 HV
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.researchgate.net/project/ENgineering-DYnamic-ViscoElasticity-to-study-cell-response-ENDYVE
 Total cost 137˙999 €
 EC max contribution 137˙999 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OPTICS11 BV NL (AMSTERDAM) coordinator 137˙999.00

Map

 Project objective

In native tissues, the extracellular matrix (ECM) provides not only physical scaffolding to cells, but also biochemical and biomechanical cues affecting cell behaviour. ECM mechanical properties are critical in the regulation of cell behaviour during tissue development, homeostasis and disease via mechano-transduction. Albeit biological tissues generally exhibit a time variant (i.e. dynamic) viscoelastic behaviour that changes during development, ageing and disease, to date most of mechano-transduction studies have focused on static elastic properties only. The ENDYVE project aims at engineering tissue dynamic viscoelasticity typical of pathophysiological processes in-vivo to investigate its role on cell behaviour. Focusing on cardiomyocyte maturation, the viscoelastic properties of foetal, neonatal, aged and infarcted cardiac tissue will be characterised and used to design cell culture substrates with temporally tuneable mechanical properties that initially mimic foetal viscoelasticity and then can be made more stiff and less viscoelastic during cell culture via a second-step biocompatible enzymatic crosslinking to recapitulate dynamic changes of cardiac viscoelasticity in-vitro. First, stem cell cardiomyocyte behaviour will be investigated at discrete levels of constant viscoelasticity by seeding human induced pluripotent stem cells on substrates prior to and after enzyme-mediated crosslinking. Then the effect of dynamic changes in substrate viscoelasticity will be characterised during culture. Engineering dynamic viscoelasticity is a critical step towards a better understating of cell-ECM interactions and mechano-transduction, and could lead to the development of new strategies to finely control cell behaviour, with numerous potential societal and clinical implication, such as obtaining mature differentiated cells from stem cells for drug screening in vitro, or limiting, if not preventing, fibrosis and tumour progression.

 Publications

year authors and title journal last update
List of publications.
2018 G. Mattei, A. Ahluwalia
A new analytical method for estimating lumped parameter constants of linear viscoelastic models from strain rate tests
published pages: , ISSN: 1385-2000, DOI: 10.1007/s11043-018-9385-0
Mechanics of Time-Dependent Materials 2019-06-13
2017 Giorgio Mattei, Ludovica Cacopardo, Arti Ahluwalia
Micro-Mechanical Viscoelastic Properties of Crosslinked Hydrogels Using the Nano-Epsilon Dot Method
published pages: 889, ISSN: 1996-1944, DOI: 10.3390/ma10080889
Materials 10/8 2019-06-13

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The information about "ENDYVE" are provided by the European Opendata Portal: CORDIS opendata.

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