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ADHERE TERMINATED

Aptamer nanostructures dual-targeted to the HER receptor family for cancer therapy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ADHERE project word cloud

Explore the words cloud of the ADHERE project. It provides you a very rough idea of what is the project "ADHERE" about.

dual gain vivo integrate strengthen host antigens drug career chemistry executed materials scientist wp2 nanomaterials fellowship training advantageous vitro stranded netherlands wp1 strategy multivalent receptor binding encompasses time physicochemical aptamers fashion receive world bioengineering transferable university additional superior bispecific wp3 egfr anti cells clinical bind perspectives young position directed disadvantages members therapy nanostructures resistance adhere aptamer expressing positioned immunotherapy form therapeutics oligonucleotides science institutes immunoglobulins groningen reducing ligands msca material cell me 24 polymer single cancer molecule myself skills her2 outcome background types dna cellular multiple zernike receptors extensive deals her1 alternative valuable

Project "ADHERE" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.rug.nl/research/zernike/polymer-chemistry-and-bioengineering/crielaard-group/
Total cost	177˙598 €
EC max contribution	177˙598 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-RI
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2018-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	177˙598.00

Map

Project objective

The proposed research programme deals with the development of aptamer nanostructures for targeted cancer therapy. Immunotherapy encompasses a growing field of anti-cancer therapeutics that target cancer cells expressing specific antigens, such as members of the HER receptor. Currently, immunoglobulins directed to HER1, better known as EGFR, and HER2 are used in the clinical management of several types of cancer. There are, however, several disadvantages associated with the production and application of immunoglobulins. Moreover, there is evidence that dual-targeting of multiple receptors at the same time is advantageous for improving clinical outcome and reducing drug resistance. Aptamers, which are short single-stranded oligonucleotides that can bind a target molecule in a similar fashion as immunoglobulins, may form, due to their physicochemical properties, a superior alternative strategy for targeted cancer therapy. In ADHERE, I will design (WP1) and investigate in vitro (WP2) and in vivo (WP3) the use of aptamer nanostructures with bispecific (against both EGFR and HER2) and multivalent (up to 4 binding ligands) targeting properties for cancer cell targeting. The 24-month research project will be executed at the department of Polymer Chemistry and Bioengineering at the Zernike Institute for Advanced Materials, University of Groningen, The Netherlands. The aim of this MSCA IF fellowship is to integrate my extensive background in targeted drug delivery and cellular therapeutics within the host institute, which is highly experienced with DNA nanomaterials and is positioned among the top 10 institutes of the world in the field of material science. Importantly, this fellowship will strengthen my career perspectives, by allowing me to gain valuable new transferable skills and receive additional high-level training. This will enable me to position myself as a leading young scientist in the field of clinical nanomaterials.

Publications

List of publications.
year	authors and title	journal	last update
2017	Bart J. Crielaard, Twan Lammers, Stefano Rivella Targeting iron metabolism in drug discovery and delivery published pages: 400-423, ISSN: 1474-1776, DOI: 10.1038/nrd.2016.248	Nature Reviews Drug Discovery 16/6	2019-06-13

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The information about "ADHERE" are provided by the European Opendata Portal: CORDIS opendata.