Explore the words cloud of the NIR-BIO-FLU project. It provides you a very rough idea of what is the project "NIR-BIO-FLU" about.
The following table provides information about the project.
ROYAL COLLEGE OF SURGEONS IN IRELAND
|Coordinator Country||Ireland [IE]|
|Total cost||175˙866 €|
|EC max contribution||175˙866 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-03-01 to 2018-02-28|
Take a look of project's partnership.
|1||ROYAL COLLEGE OF SURGEONS IN IRELAND||IE (DUBLIN)||coordinator||175˙866.00|
Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, the optimisation of preclinical and clinical tests for new medication and act as a real-time guide during surgery. This proposal seeks support for a MSC Fellowship to develop new biologically responsive off to on switchable NIR fluorochromes i.e. NIR fluorescent probes that respond selectively to cellular uptake and with specificity for cancer cells achieved through bio-conjugation with proven targeting agents. Specifically, the focus is on the design, synthesis, photophysical characterisation, in vitro cell imaging and preliminary in vivo assessment of such probes for the ultimate in vivo detection of colorectal cancer metastasis. Colorectal cancer is the third most common cancer and remains a major public health issue in Europe because of its high prevalence, morbidity, and mortality. The synergetic combination of the host laboratory’s interdisciplinary expertise, the host institution’s ability to deliver a comprehensive training program and the applicant’s excellent prior Ph.D. training experience in developing fluorescence chromophores with function-tailored photophysical properties is the perfect match to deliver the project goals and provide the stepping stone to independent researcher for the applicant.
|year||authors and title||journal||last update|
Harrison C. Daly, Gonzalo Sampedro, Corentin Bon, Dan Wu, Ghazi Ismail, Ronan A. Cahill, Donal F. O\'Shea
BF 2 -azadipyrromethene NIR-emissive fluorophores with research and clinical potential
published pages: 392-400, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.04.051
|European Journal of Medicinal Chemistry 135||2018-03-14|
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The information about "NIR-BIO-FLU" are provided by the European Opendata Portal: CORDIS opendata.
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