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METAFORA

Miniaturised Metabolomics Platform for Microvascular Research

Total Cost €

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EC-Contrib. €

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Partnership

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Project "METAFORA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT LEIDEN 

Organization address
address: RAPENBURG 70
city: LEIDEN
postcode: 2311 EZ
website: www.universiteitleiden.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://yuliya.exosome.nl/publications/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT LEIDEN NL (LEIDEN) coordinator 177˙598.00

Map

 Project objective

Preventing and treating progressive microvascular loss (i.e. rarefaction) is a major challenge in cardiovascular medicine. Microvascular disease is a multifactorial disease with no effective treatment. Long-term exposure to adverse metabolic and haemodynamic conditions such as hypertension, obesity and diabetes can cause microvascular destabilisation, loss of tissue capillaries, and eventual organ failure. Interestingly, not all diabetic patients develop kidney failure. The missing link to developing effective strategies for treating multifactorial diseases, including microvascular disease, is detailed mechanistic insight into the relationship between disease pathogenesis at the organ/cellular level at the systemic/organism level. This project, METAFORA, aims to develop novel and analytical technologies to allow a new approach to understand the pathology of microvascular disease. METAFORA will develop a miniaturized metabolomics workflow to study metabolic pathways in an in-vitro microfluidic 3D microvasculature platform with organotypic functionality (the so-called organ-on-a-chip) to create personalised in-vitro models based on patient-derived human cells. This platform will enable the assessment of biochemical disease processes at the cell/organ level in the ‘whole-patient’ context by perfusing the patient’s own blood through the vasculature model. METAFORA will use and optimize a novel separation and preconcentration method, depletion zone isotachophoresis, for the miniaturised analytical platform, which will be combined with mass spectrometry for metabolite profiling.

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The information about "METAFORA" are provided by the European Opendata Portal: CORDIS opendata.

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