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ChroMe SIGNED

Chromatin and Metabolism Chromatin-metabolism interactions as targets for healthy living

Total Cost €

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EC-Contrib. €

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Partnership

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 ChroMe project word cloud

Explore the words cloud of the ChroMe project. It provides you a very rough idea of what is the project "ChroMe" about.

genetic    provides    industry    esrs    public    epigenetics    phd    lifestyle    sugars    medicine    national    diseases    strengths    burden    metabolism    craft    training    pioneering    supervised    insulin    drug    dissect    systematically    nor    experiments    poorly    collaborative    receive    exercise    billion    engage    governments    translate    etn    10    expert    leaders    mechanisms    technologies    link    causes    human    metabolic    health    overweight    50    personal    establishes    network    interface    bioinformatic    pandemic    local    molecular    academia    engagement    co    obese    20    obesity    110    links    capital    urgent    equips    chromatin    gut    tune    transferable    resistance    chrome    regulate    diabetes    reveal    disorders    interactions    europeans    substantially    promise    labs    nutritional    international    translational    fight    starting    career    academic    estimates    treatment    exploits    gene    drugs    skills    microbiome    levels    intersectorial    extensive    therapies    innovative    nutrients    physiology    syndrome    invest   

Project "ChroMe" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.chromenetwork.eu
 Total cost 3˙825˙128 €
 EC max contribution 3˙825˙128 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 747˙649.00
2    FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS ES (BARCELONA) participant 495˙745.00
3    CHRONOS THERAPEUTICS LIMITED UK (OXFORD) participant 273˙287.00
4    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 273˙287.00
5    NESTEC SA CH (VEVEY) participant 265˙226.00
6    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 263˙659.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 262˙875.00
8    4 SC AG DE (PLANEGG MARTINSRIED) participant 249˙216.00
9    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 249˙216.00
10    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00
11    BIOBAM BIOINFORMATICS SL ES (VALENCIA) participant 247˙872.00
12    UNIVERSITAT ROVIRA I VIRGILI ES (TARRAGONA) participant 247˙872.00
13    4SC DISCOVERY GMBH DE (PLANEGG MARTINSRIED) participant 0.00
14    NESTEC SA CH (LAUSANNE) participant 0.00

Map

 Project objective

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chromatin are poorly understood, and drug targets are only starting to be identified. Pioneering experiments by ChroMe labs now reveal how sugars, exercise, the gut microbiome and novel drugs regulate chromatin. These novel links promise to substantially improve our understanding and treatment of metabolic disorders. National governments and the EU invest major resources to address the burden of the “metabolic syndrome”. However, there is an urgent need for expert human capital able to dissect metabolic diseases, exploit new targets and establish innovative therapies. No local nor international program currently provides adequate training at this emerging interface of chromatin and metabolism.

ChroMe establishes a timely and intersectorial ETN that exploits Europe’s strengths in epigenetics, physiology and medicine to translate our molecular knowledge of chromatin–metabolism interactions into therapies. Our ESRs receive advanced training in emerging technologies, bioinformatic and translational approaches, and all engage in collaborative PhD projects co-supervised by academia and industry. ChroMe’s extensive transferable skills, dissemination and public engagement program equips our ESRs with the experience and personal network needed for a career in metabolic health. By systematically involving the non-academic sector at every level in our research, training and management, ChroMe will craft future European leaders with the necessary knowledge and skills to fight the metabolic syndrome pandemic.

 Deliverables

List of deliverables.
Network website Websites, patent fillings, videos etc. 2019-09-13 11:18:42
Call for abstracts Documents, reports 2019-09-13 11:18:42

Take a look to the deliverables list in detail:  detailed list of ChroMe deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Tess Tsai-Hsiu Lu, Steffen Heyne, Erez Dror, Eduard Casas, Laura Leonhardt, Thorina Boenke, Chih-Hsiang Yang, Sagar, Laura Arrigoni, Kevin Dalgaard, Raffaele Teperino, Lennart Enders, Madhan Selvaraj, Marius Ruf, Sunil J. Raja, Huafeng Xie, Ulrike Boenisch, Stuart H. Orkin, Francis C. Lynn, Brad G. Hoffman, Dominic Grün, Tanya Vavouri, Adelheid M. Lempradl, J. Andrew Pospisilik
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
published pages: 1294-1308.e7, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.04.013
Cell Metabolism 27/6 2020-04-15
2019 Joan Miro-Blanch, Oscar Yanes
Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00638
Frontiers in Genetics 10 2020-04-15
2020 Ahmed M. Abdelmoez, Laura Sardón Puig, Jonathon A. B. Smith, Brendan M. Gabriel, Mladen Savikj, Lucile Dollet, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon
Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism
published pages: C615-C626, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00540.2019
American Journal of Physiology-Cell Physiology 318/3 2020-04-15
2018 Sarah Hurtado-Bagès, Iva Guberovic, Marcus Buschbeck
The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism
published pages: 1-10, ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00417
Frontiers in Genetics 9 2020-04-15
2019 Paula Ortega-Prieto, Catherine Postic
Carbohydrate Sensing Through the Transcription Factor ChREBP
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00472
Frontiers in Genetics 10 2020-04-15
2018 Michael Maher, Jeannine Diesch, Raquel Casquero, Marcus Buschbeck
Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00405
Frontiers in Genetics 9 2020-04-15
2018 Evangelia Tzika, Tobias Dreker, Axel Imhof
Epigenetics and Metabolism in Health and Disease
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00361
Frontiers in Genetics 9 2020-04-15
2018 Silvia Raineri, Jane Mellor
IDH1: Linking Metabolism and Epigenetics
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00493
Frontiers in Genetics 9 2020-04-15
2018 Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian Y. H. Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A. Malagon, Patricia Valerio, Marcos F. Fondevila, Johan Fernø, Maria M. Malagon, Raian Contreras, Paul Pfluger, Jens C. Brüning, Giles Yeo
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05711-6
Nature Communications 9/1 2020-04-15
2018 Laura Sardon Puig, Miriam Valera-Alberni, Carles Cantó, Nicolas J. Pillon
Circadian Rhythms and Mitochondria: Connecting the Dots
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00452
Frontiers in Genetics 9 2020-04-15
2018 Miriam Valera-Alberni, Carles Canto
Mitochondrial stress management: a dynamic journey
published pages: 253-274, ISSN: 2523-0204, DOI: 10.15698/cst2018.10.158
Cell Stress 2/10 2020-04-15
2018 Christophe O. Soulage, Laura Sardón Puig, Laurent Soulère, Bader Zarrouki, Michel Guichardant, Michel Lagarde, Nicolas J. Pillon
Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation
published pages: 688-699, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4528-4
Diabetologia 61/3 2020-04-15
2019 Chih-Hsiang Yang, John Andrew Pospisilik
Polyphenism – A Window Into Gene-Environment Interactions and Phenotypic Plasticity
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00132
Frontiers in Genetics 10 2020-04-15
2020 Laura Sardon Puig, Nicolas J. Pillon, Erik Näslund, Anna Krook, Juleen R. Zierath
Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression
published pages: E1-E10, ISSN: 0193-1849, DOI: 10.1152/ajpendo.00289.2019
American Journal of Physiology-Endocrinology and Metabolism 318/1 2020-04-15
2018 Marek Kozlowski, David Corujo, Michael Hothorn, Iva Guberovic, Imke K Mandemaker, Charlotte Blessing, Judith Sporn, Arturo Gutierrez‐Triana, Rebecca Smith, Thomas Portmann, Mathias Treier, Klaus Scheffzek, Sebastien Huet, Gyula Timinszky, Marcus Buschbeck, Andreas G Ladurner
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
published pages: 1-13, ISSN: 1469-221X, DOI: 10.15252/embr.201744445
EMBO reports 19/10 2020-04-15
2019 Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S.J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller, Eicke Latz
Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase
published pages: 997-1011.e7, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.11.009
Immunity 51/6 2020-04-15
2020 Nicolas J. Pillon, Brendan M. Gabriel, Lucile Dollet, Jonathon A. B. Smith, Laura Sardón Puig, Javier Botella, David J. Bishop, Anna Krook, Juleen R. Zierath
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13869-w
Nature Communications 11/1 2020-04-15
2018 Víctor Sánchez-Gaya, Salvador Casaní-Galdón, Manuel Ugidos, Zheng Kuang, Jane Mellor, Ana Conesa, Sonia Tarazona
Elucidating the Role of Chromatin State and Transcription Factors on the Regulation of the Yeast Metabolic Cycle: A Multi-Omic Integrative Approach
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00578
Frontiers in Genetics 9 2020-04-15
2018 Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschöp, Paul T. Pfluger
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
published pages: 2456-2465, ISSN: 0012-1797, DOI: 10.2337/db18-0146
Diabetes 67/11 2020-04-15
2019 Raian E. Contreras, Sonja C. Schriever, Paul T. Pfluger
Physiological and Epigenetic Features of Yoyo Dieting and Weight Control
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.01015
Frontiers in Genetics 10 2020-04-15
2018 Berta Font-Cunill, Luis Arnes, Jorge Ferrer, Lori Sussel, Anthony Beucher
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00524
Frontiers in Genetics 9 2020-04-15
2019 Haris A. Khan, Carla E. Margulies
The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00591
Frontiers in Genetics 10 2020-04-15
2019 Magdalini Serefidou, Anuroop Venkateswaran Venkatasubramani, Axel Imhof
The Impact of One Carbon Metabolism on Histone Methylation
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00764
Frontiers in Genetics 10 2020-04-15
2019 Tia Tyrsett Kuo, Andreas G. Ladurner
Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.01210
Frontiers in Genetics 10 2020-04-15
2017 Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera‐Alberni, Roy Combe, Antonio Zorzano, Carles Cantó
Mfn2 is critical for brown adipose tissue thermogenic function
published pages: 1543-1558, ISSN: 0261-4189, DOI: 10.15252/embj.201694914
The EMBO Journal 36/11 2019-09-13
2017 Melanija Posavec Marjanović, Sarah Hurtado-Bagès, Maximilian Lassi, Vanesa Valero, Roberto Malinverni, Hélène Delage, Miriam Navarro, David Corujo, Iva Guberovic, Julien Douet, Pau Gama-Perez, Pablo M Garcia-Roves, Ivan Ahel, Andreas G Ladurner, Oscar Yanes, Philippe Bouvet, Mònica Suelves, Raffaele Teperino, J Andrew Pospisilik, Marcus Buschbeck
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption
published pages: 902-910, ISSN: 1545-9993, DOI: 10.1038/nsmb.3481
Nature Structural & Molecular Biology 24/11 2019-09-13

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