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Biomimetic trick to re-balance Osteblast-Osteoclast loop in osteoporoSis treatment: a Topological and materials driven approach

Total Cost €


EC-Contrib. €






 BOOST project word cloud

Explore the words cloud of the BOOST project. It provides you a very rough idea of what is the project "BOOST" about.

socio    believe    cutting    disabilities    mechanical    treat    realization    millions    avant    garde    microenvironment    bone    stimulation    negative    coupling    cells    steadily    lifetime    fragility    benchmark    opening    biomimetic    unprecedented    properly    community    fractures    favoring    balance    smart    prove    osteoporosis    scientific    locally    fixation    edge    one    followed    osteoblasts    life    biomaterial    architecture    unbalanced    lifestyle    therapy    osteoclast    ones    trick    fifties    contribution    healthy    financial    osteoclasts    cooperation    resorption    scaffold    drug    reduce    manufacture    people    treating    mimics    burdens    coordinated    positive    occurs    treatment    population    boost    stimulated    efficacy    stimulating    economic    osteoblast    treatments    strategies    tens    scientists    aged    active    fracture    ageing    union    balanced    entail    substitutes    remodelling    coupled    act    burden    op    dramatic    tissues   

Project "BOOST" data sheet

The following table provides information about the project.


Organization address
city: TORINO
postcode: 10129

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 1˙977˙500 €
 EC max contribution 1˙977˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 1˙977˙500.00


 Project objective

One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in their lifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadily increasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestyle but OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in this field is still far from taking its expected leading role in cutting-edge research. Bone remodelling is a well-coordinated process of bone resorption by osteoclasts followed by the production of new bone by osteoblasts. This process occurs continuously throughout life in a coupling with a positive balance during growth and negative with ageing, which can result in OP. We believe that an architecture driven stimulation of the osteoclast/osteoblast coupling, with an avant-garde focus on osteoclasts activity, is the key to success in treating unbalanced bone remodelling. We aim to manufacture a scaffold that mimics healthy bone features which will establish a new microenvironment favoring a properly stimulated and active population of osteoclasts and osteoblasts, i.e. a well-balanced bone cooperation. After 5 years we will be able to prove the efficacy of this approach. A benchmark will be set up for OP fracture treatment and for the realization of smart bone substitutes that will be able to locally “trick” aged bone cells stimulating them to act as healthy ones. BOOST results will have an unprecedented impact on the scientific research community, opening a new approach to set up smart, biomimetic strategies to treat aged, unbalanced bone tissues and to reduce OP-associated disabilities and financial burdens.


year authors and title journal last update
List of publications.
2020 Giorgia Montalbano, Giulia Molino, Sonia Fiorilli, Chiara Vitale-Brovarone
Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: A hybrid formulation for 3D printing of bone scaffolds
published pages: , ISSN: 0955-2219, DOI: 10.1016/j.jeurceramsoc.2020.02.018
Journal of the European Ceramic Society 2020-04-24
2019 Giorgia Montalbano, Giorgia Borciani, Carlotta Pontremoli, Gabriela Ciapetti, Monica Mattioli-Belmonte, Sonia Fiorilli, Chiara Vitale-Brovarone
Development and Biocompatibility of Collagen-Based Composites Enriched with Nanoparticles of Strontium Containing Mesoporous Glass
published pages: 3719, ISSN: 1996-1944, DOI: 10.3390/ma12223719
Materials 12/22 2020-04-24
2020 Giulia Molino, Maria Chiara Palmieri, Giorgia Montalbano, Sonia Fiorilli, Chiara Vitale-Brovarone
Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review
published pages: 22001, ISSN: 1748-605X, DOI: 10.1088/1748-605X/ab5f1a
Biomedical Materials 15/2 2020-04-24
2019 Giulia Molino, Alessio Dalpozzi, Gabriela Ciapetti, Massimo Lorusso, Chiara Novara, Marco Cavallo, Nicola Baldini, Fabrizio Giorgis, Sonia Fiorilli, Chiara Vitale-Brovarone
Osteoporosis-related variations of trabecular bone properties of proximal human humeral heads at different scale lengths
published pages: 103373, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2019.103373
Journal of the Mechanical Behavior of Biomedical Materials 100 2020-04-24
2017 Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone
Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration
published pages: 493-504, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012
Acta Biomaterialia 55 2019-06-18
2017 Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone
Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review
published pages: 15, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010015
Bioengineering 4/1 2019-06-18
2018 Alessandra Bari, Giulia Molino, Sonia Fiorilli, Chiara Vitale-Brovarone
Novel multifunctional strontium-copper co-substituted mesoporous bioactive particles
published pages: 37-40, ISSN: 0167-577X, DOI: 10.1016/j.matlet.2018.04.006
Materials Letters 223 2019-05-28
2018 Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone
The Incorporation of Strontium to Improve Bone-Regeneration Ability of Mesoporous Bioactive Glasses
published pages: 678, ISSN: 1996-1944, DOI: 10.3390/ma11050678
Materials 11/5 2019-05-28
2018 Giorgia Montalbano, Sonia Fiorilli, Andrea Caneschi, Chiara Vitale-Brovarone
Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials
published pages: 700, ISSN: 1996-1944, DOI: 10.3390/ma11050700
Materials 11/5 2019-05-28

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