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NanoPokers SIGNED

Deciphering cell heterogeneity in tumors using arrays of nanowires to controllably poke single cells in longitudinal studies

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoPokers" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://portal.research.lu.se/portal/en/persons/christelle-prinz
 Total cost 2˙621˙251 €
 EC max contribution 2˙621˙251 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 2˙621˙251.00

Map

 Project objective

Cancer is responsible for 20% of all deaths in Europe. Current cancer research is based on cell ensemble measurements or on snapshot studies of individual cells. However, cancer is a systemic disease, involving many cells that interact and evolve over time in a complex manner, which cell ensemble studies and snapshot studies cannot grasp. It is therefore crucial to investigate cancer at the single cell level and in longitudinal studies (over time). Despite the recent developments in micro- and nanotechnologies, combined with live cell imaging, today, there is no method available that meets the crucial need for global monitoring of individual cell responses to stimuli/perturbation in real-time. This project addresses this crucial need by combining super resolution live-cell imaging and the development of sensors, as well as injection devices based on vertical nanowire arrays. The devices will penetrate multiple single cells in a fully controlled manner, with minimal invasiveness.

The objectives of the project are: 1) To develop nanowire based-tools in order to gain controlled and reliable access to the cell interior with minimal invasiveness. 2) Developing mRNA sensing and biomolecule injection capabilities based on nanowires. 3) Performing longitudinal single cell studies in tumours, including monitoring gene expression in real time, under controlled cell perturbation.

By enabling global, long term monitoring of individual tumour cells submitted to controlled stimuli, the project will open up new horizons in Biology and in Medical Research. It will enable ground-breaking discoveries in understanding the complexity of molecular events underlying the disease. This cross-disciplinary project will lead to paradigm-shifting research, which will enable the development of optimal treatment strategies. This will be applicable, not only for cancer, but also for a broad range of diseases, such as diabetes and neurodegenerative diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Mercy Lard, Heiner Linke, Christelle N Prinz
Biosensing using arrays of vertical semiconductor nanowires: mechanosensing and biomarker detection
published pages: 214003, ISSN: 0957-4484, DOI: 10.1088/1361-6528/ab0326
Nanotechnology 30/21 2020-03-25
2018 Zhen Li, Sofia Kamlund, Till Ryser, Mercy Lard, Stina Oredsson, Christelle N. Prinz
Single cell analysis of proliferation and movement of cancer and normal-like cells on nanowire array substrates
published pages: 7042-7049, ISSN: 2050-7518, DOI: 10.1039/c8tb02049c
Journal of Materials Chemistry B 6/43 2020-03-25
2018 Damiano Verardo, Frida W. Lindberg, Nicklas Anttu, Cassandra S. Niman, Mercy Lard, Aleksandra P. Dabkowska, Tommy Nylander, Alf Månsson, Christelle N. Prinz, Heiner Linke
Nanowires for Biosensing: Lightguiding of Fluorescence as a Function of Diameter and Wavelength
published pages: 4796-4802, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b01360
Nano Letters 18/8 2020-03-25
2017 Joanna Oracz, Karl Adolfsson, Volker Westphal, Czesław Radzewicz, Magnus T. Borgström, Steffen J. Sahl, Christelle N. Prinz, Stefan W. Hell
Ground State Depletion Nanoscopy Resolves Semiconductor Nanowire Barcode Segments at Room Temperature
published pages: 2652-2659, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b00468
Nano Letters 17/4 2020-03-25

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The information about "NANOPOKERS" are provided by the European Opendata Portal: CORDIS opendata.

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