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NPAD SIGNED

Multiregional rtfMRI Neurofeedback for the Prevention of Alzheimer's Disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NPAD" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER 

Organization address
address: CALLE WELLINGTON 30
city: BARCELONA
postcode: 8005
website: www.fpmaragall.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://fpmaragall.org/en/pioneering-neurofeedback-to-understand-alzheimers/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER ES (BARCELONA) coordinator 158˙121.00

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 Project objective

This project aims at predicting early cognitive decline using a neurofeedback performance endophenotype based on realtime functional magnetic resonance imaging in a population at risk for Alzheimer’s Disease (AD). It has been proven that AD biomarkers change decades before the development of symptoms. In addition, there is a lack of robust hypersensitive methods capable of predicting impending cognitive decline in healthy subjects at risk. This constitutes a crucial obstacle for the implementation of AD prevention trials. To address this, we will identify and characterize a novel neurofeedback performance endophenotype in a subsample from a cohort of 2743 cognitively healthy volunteers at risk for AD. This will be based on state-of-the-art neuroimaging technology, in combination with a novel sensitive neuropsychological test that detects subtle alterations in episodic memory, which has been validated for our cohort. Then, we will evaluate the impact on our newly developed neurofeedback performance endophenotype of factors known to be related to AD such as various clinical and lifestyle variables, amyloid deposition, genetic background (including, but not restricted to APOE4) and most importantly cognitive reserve. A specific aim is to test the hypothesis that neurofeedback performance can become a reliable proxy to measure cognitive reserve. Finally, we will develop a novel statistical predictive model, featuring all the relevant genetic and clinical variables and will assess the capacity of neurofeedback performance for predicting impending cognitive decline during a two-year period in AD descendants.

 Publications

year authors and title journal last update
List of publications.
2017 Skouras, Stavros; Salvadó, Gemma; Andersson, Patrik; Falcon, Carles; Koush, Yury; Torner, Jordi; Alpiste, Francisco; Gispert, Juan Domingo; Molinuevo, José Luís
Virtual reality neurofeedback paradigm for the assessment of hippocampal hyperactivity and cognitive reserve.
published pages: , ISSN: , DOI: 10.5281/zenodo.1311250
1st International Conference on Cognitive Reserve in the Dementias (ResDem) 2019-06-13
2018 Stavros Skouras, Frank Scharnowski
The effects of psychiatric history and age on self-regulation of the default mode network
published pages: , ISSN: , DOI: 10.1101/342220
bioRxiv - the preprint server for biology bioRxiv 342220 2019-06-13
2017 Paula Marcela Petrone, Verónica Vilaplana, Adriá Casamitjana, Dalila Sánchez Escobedo, Alan Tucholka, Raffaele Cacciaglia, Gregory Operto, Stavros Skouras, Carles Falcon, José Luis Molinuevo, Juan Domingo Gispert
MAGNETIC RESONANCE IMAGING AND MACHINE LEARNING MAKE A VALUABLE COMBINED TOOL FOR THE SCREENING OF PRECLINICAL AD
published pages: P1245, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2017.07.457
Alzheimer\'s & Dementia 13/7 2019-06-13
2018 Stavros Skouras
Six informal reports of results and project progress presented at internal research group meetings.
published pages: , ISSN: , DOI: 10.5281/zenodo.1311674
2019-06-13
2017 Skouras, Stavros; Salvadó, Gemma; Anderson, Patrik; Falcon, Carles; Koush, Yury; Torner, Jordi; Alpiste, Francisco; Gispert, Juan Domingo; Molinuevo, José Luís
Hippocampal CA1 down-regulation performance as a biomarker of preclinical Alzheimer\'s disease.
published pages: , ISSN: , DOI: 10.5281/zenodo.1311619
Real-time functional imaging and neurofeedback conference (rtFIN) 2019-06-13
2018 Stavros Skouras, David Prados, Jordi Torner, Franciso Alpiste and members of the LAM-UPC research group.
Open-source software: Multipurpose virtual reality environment for biomedical and health applications
published pages: , ISSN: , DOI:
GitHub - The world\'s leading software development platform 2019-06-13
2017 Skouras, Stavros; Falcon, Carles; Tucholka, Alan; Rami, Lorena; Sanchez-Valle, Raquel; Lladó, Albert; Gispert, Juan Domingo; Molinuevo, José Luís
Towards a functional neuromarker for preclinical AD: Eigenvector centrality reveals preclinical differences of functional information flow in the hippocampus, precuneus, cerebellum and inferior parietal lobule.
published pages: , ISSN: , DOI: 10.5281/zenodo.1311637
Alzheimer\'s Association International Conference 2019-06-13
2018 Stavros Skouras, Carles Falcon, Alan Tucholka, Lorena Rami, Raquel Sanchez-Valle, Albert Llado, Juan D. Gispert, Jose Luis Molinuevo
Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer\'s disease.
published pages: , ISSN: , DOI: 10.1101/342246
bioRxiv - the preprint server for biology bioRxiv 342246 2019-06-13
2017 Stavros Skouras, Stephan Heunis, Lydia Hellrung, Johan van der Meer
Open-source software: Real-time Quality Control toolbox
published pages: , ISSN: , DOI:
GitHub - The world\'s leading software development platform 2019-06-13
2018 Jordi Torner, Stavros Skouras, Juan Domingo Gispert, Jose Luis Molinuevo, Francisco Alpiste
Multipurpose virtual reality environment for biomedical and health applications
published pages: , ISSN: , DOI: 10.1101/366302
bioRxiv - the preprint server for biology bioRxiv 366302 2019-06-13
2017 Hellrung, Lydia; van der Meer, Johan; Bergert, Susanne; Sladky, Ronald; Pamplona, Gustavo SP; Scharnowski, Frank; Koush, Yury; Mehler, David MA; Linden, David EJ; Falcon, Carles; Gispert, Juan Domigno; Molinuevo, José Luís; Skouras, Stavros
rtQC: An open-source collaborative framework for quality control methods in real-time functional magnetic resonance imaging.
published pages: , ISSN: , DOI: 10.5281/zenodo.1311610
Real-time functional imaging and neurofeedback conference (rtFIN) 2019-06-13
2017 Stavros Skouras, Carles Falcon, Paula Marcela Petrone, Alan Tucholka, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Juan Domingo Gispert, José Luis Molinuevo
TOWARD A FUNCTIONAL NEUROMARKER FOR PRECLINICAL AD: EIGENVECTOR CENTRALITY REVEALS PRECLINICAL DIFFERENCES OF FUNCTIONAL INFORMATION FLOW IN THE HIPPOCAMPUS, PRECUNEUS, CEREBELLUM AND INFERIOR PARIETAL LOBULE
published pages: P1348-P1349, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2017.06.2082
Alzheimer\'s & Dementia 13/7 2019-06-13

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