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HybCell SIGNED

Engineering of hybrid cells using lab-on-chip technology

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HybCell" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙971˙250 €
 EC max contribution 1˙971˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 1˙971˙250.00

Map

 Project objective

The overall aim of the here described projects is to learn fundamental characteristics of cellular organization and compartmentalization, in particular the role of the lipid membrane, and to exploit this knowledge for engineering minimal cells with a great impact in the context of synthetic biology and also for pharmaceutical and medical applications. The first major objective aims at combining natural cell membranes with synthetic membranes to form defined hybrid systems with the size of cells or cell organelles. This approach has the intriguing advantage that the membrane receptors or channels are reconstituted in the hybrid cell and remain functional. In consequence, signaling pathways of a cell can be mimicked and therefore, the vesicles can be addressed similar to a cell or can serve as cell-free sensor. The second major objective addresses the challenge to build multi-compartment systems. In a defined number and formulation, smaller compartments are enclosed in a larger vesicle and carry other constituents than the lumen of the larger host vesicles (catalysts or enzymes, respectively; DNA; buffer systems; other active biomolecules). With the acquired fundamental knowledge on membrane permeability and fusion, multi-step reactions can be conducted, where several compartments are involved, just like in a living cell. The key methods to address these challenges are based on lab-on-chip technology that provide the unique potential to systematically investigate membrane properties by allowing precise formation, positioning, manipulation and analysis of the membranes; together with many more advantages such as the fast and controlled fluid supply, the possibility of tailoring the chemical surface patterns and surface topology and the application of electrical fields. Microfluidic platform will allow going far beyond the existing methods in membrane research, so that controlled bottom-up formation of simple to more and more complex systems becomes possible.

 Publications

year authors and title journal last update
List of publications.
2017 Ya Zhang, Yannick R. F. Schmid, Sandra Luginbühl, Qiang Wang, Petra S. Dittrich, Peter Walde
Spectrophotometric Quantification of Peroxidase with p -Phenylene-diamine for Analyzing Peroxidase-Encapsulating Lipid Vesicles
published pages: 5484-5493, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00423
Analytical Chemistry 89/10 2019-06-18
2017 L. Armbrecht, G. Gabernet, F. Kurth, J. A. Hiss, G. Schneider, P. S. Dittrich
Characterisation of anticancer peptides at the single-cell level
published pages: 2933-2940, ISSN: 1473-0197, DOI: 10.1039/c7lc00505a
Lab on a Chip 17/17 2019-06-18
2017 N. Nuti, P. E. Verboket, P. S. Dittrich
Multivesicular droplets: a cell model system to study compartmentalised biochemical reactions
published pages: 3112-3119, ISSN: 1473-0197, DOI: 10.1039/c7lc00710h
Lab on a Chip 17/18 2019-06-18
2017 Bernhard Sebastian, Tobias Favero, Petra S. Dittrich
The Effects of Shear Force Transmission Across Vesicle Membranes
published pages: 6128-6134, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b02676
The Journal of Physical Chemistry Letters 8/24 2019-06-18
2016 Lucas Armbrecht, Petra S. Dittrich
Recent Advances in the Analysis of Single Cells
published pages: 2-21, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04255
Analytical Chemistry 89/1 2019-06-18
2017 Can Dincer, Richard Bruch, André Kling, Petra S. Dittrich, Gerald A. Urban
Multiplexed Point-of-Care Testing – xPOCT
published pages: 728-742, ISSN: 0167-7799, DOI: 10.1016/j.tibtech.2017.03.013
Trends in Biotechnology 35/8 2019-06-18
2017 S. Bachler, C.-Ch. Lin, C. Del Don, and P. S. Dittrich
Combination of a microfluidic device and fluorescence correlation spectroscopy to study peptide translocation across model membranes
published pages: 967-968, ISSN: , DOI:
Proceedings of the microTAS conference Annual 2019-06-18
2017 F. Kurth, O. G. Weingart, K. Eyer, M. J. Loessner, P. S. Dittrich
Microfluidic liposome biosensor for detecting botulinum neurotoxin physiological activity
published pages: 973-974, ISSN: , DOI:
Proceedings of the microTAS conference Annual 2019-06-18
2018 Phillip Kuhn, Klaus Eyer, Petra S. Dittrich
A microfluidic device for the delivery of enzymes into cells by liposome fusion
published pages: 149-156, ISSN: 1618-0240, DOI: 10.1002/elsc.201600150
Engineering in Life Sciences 18/2 2019-06-18
2017 Max Pillong, Jan A. Hiss, Petra Schneider, Yen-Chu Lin, Gernot Posselt, Bernhard Pfeiffer, Markus Blatter, Alex T. Müller, Simon Bachler, Claudia S. Neuhaus, Petra S. Dittrich, Karl-Heinz Altmann, Silja Wessler, Gisbert Schneider
Rational Design of Membrane-Pore-Forming Peptides
published pages: 1701316, ISSN: 1613-6810, DOI: 10.1002/smll.201701316
Small 13/40 2019-06-18
2018 Bernhard Sebastian, Petra S. Dittrich
Microfluidics to Mimic Blood Flow in Health and Disease
published pages: 483-504, ISSN: 0066-4189, DOI: 10.1146/annurev-fluid-010816-060246
Annual Review of Fluid Mechanics 50/1 2019-06-18
2018 Felix Kurth, Petra S. Dittrich, Peter Walde, Dieter Seebach
Influence of the Membrane Dye R18 and of DMSO on Cell Penetration of Guanidinium-Rich Peptides
published pages: e1800302, ISSN: 1612-1872, DOI: 10.1002/cbdv.201800302
Chemistry & Biodiversity 15/10 2019-04-17
2018 Yannick Schmid, Petra S. Dittrich
Towards Artificial Cells: Electrofusion of Lipid Vesicles on-chip
published pages: 1390-1392, ISSN: , DOI:
Proceedings of the microTAS conference Annual 2019-04-17
2018 Marcel Grogg, Donald Hilvert, Marc-Olivier Ebert, Albert K. Beck, Dieter Seebach, Felix Kurth, Petra S. Dittrich, Christof Sparr, Sergio Wittlin, Matthias Rottmann, Pascal Mäser
Cell Penetration, Herbicidal Activity, and in-vivo -Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin
published pages: e1800112, ISSN: 0018-019X, DOI: 10.1002/hlca.201800112
Helvetica Chimica Acta 101/10 2019-04-17
2018 Chao-Chen Lin, Michael Bachmann, Simon Bachler, Koushik Venkatesan, Petra S. Dittrich
Tunable Membrane Potential Reconstituted in Giant Vesicles Promotes Permeation of Cationic Peptides at Nanomolar Concentrations
published pages: 41909-41916, ISSN: 1944-8244, DOI: 10.1021/acsami.8b12217
ACS Applied Materials & Interfaces 10/49 2019-04-17
2018 Patrick Drücker, Simon Bachler, Heidi Wolfmeier, Roman Schoenauer, René Köffel, Viktoria S. Babiychuk, Petra S. Dittrich, Annette Draeger, Eduard B. Babiychuk
Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains
published pages: 795-805, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2018.04.010
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863/8 2019-04-17

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