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BoneImplant SIGNED

Monitoring bone healing around endosseous implants: from multiscale modeling to the patient’s bed

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BoneImplant" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙992˙154 €
 EC max contribution 1˙992˙154 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙992˙154.00

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 Project objective

Implants are often employed in orthopaedic and dental surgeries. However, risks of failure, which are difficult to anticipate, are still experienced and may have dramatic consequences. Failures are due to degraded bone remodeling at the bone-implant interface, a multiscale phenomenon of an interdisciplinary nature which remains poorly understood. The objective of BoneImplant is to provide a better understanding of the multiscale and multitime mechanisms at work at the bone-implant interface. To do so, BoneImplant aims at studying the evolution of the biomechanical properties of bone tissue around an implant during the remodeling process. A methodology involving combined in vivo, in vitro and in silico approaches is proposed. New modeling approaches will be developed in close synergy with the experiments. Molecular dynamic computations will be used to understand fluid flow in nanoscopic cavities, a phenomenon determining bone healing process. Generalized continuum theories will be necessary to model bone tissue due to the important strain field around implants. Isogeometric mortar formulation will allow to simulate the bone-implant interface in a stable and efficient manner. In vivo experiments realized under standardized conditions will be realized on the basis of feasibility studies. A multimodality and multi-physical experimental approach will be carried out to assess the biomechanical properties of newly formed bone tissue as a function of the implant environment. The experimental approach aims at estimating the effective adhesion energy and the potentiality of quantitative ultrasound imaging to assess different biomechanical properties of the interface. Results will be used to design effective loading clinical procedures of implants and to optimize implant conception, leading to the development of therapeutic and diagnostic techniques. The development of quantitative ultrasonic techniques to monitor implant stability has a potential for industrial transfer.

 Publications

year authors and title journal last update
List of publications.
2019 Yoann Hériveaux, Vu-Hieu Nguyen, Vladimir Brailovski, Cyril Gorny, Guillaume Haïat
Reflection of an ultrasonic wave on the bone−implant interface: Effect of the roughness parameters
published pages: 3370-3381, ISSN: 0001-4966, DOI: 10.1121/1.5109668
The Journal of the Acoustical Society of America 145/6 2019-11-08
2019 Maria Letizia Raffa, Vu-Hieu Nguyen, Elisabeth Tabor, Katharina Immel, Victor Housset, Charles-Henri Flouzat-Lachaniette, Guillaume Haiat
Dependence of the primary stability of cementless acetabular cup implants on the biomechanical environment
published pages: 95441191987925, ISSN: 0954-4119, DOI: 10.1177/0954411919879250
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 2019-11-07
2019 Immel, K., Duong, TX, Nguyen, VH, Haiat G and Sauer, R
A modified Coulomb\'s law for the tangential debonding of osseointegrated implants
published pages: , ISSN: 1617-7959, DOI:
Biomech Model Mechanobiol 2019-11-07
2019 Yoann Hériveaux, Vu-Hieu Nguyen, Didier Geiger, Guillaume Haïat
Elastography of the bone-implant interface
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50665-4
Scientific Reports 9/1 2019-11-07
2019 M. MARTIN, T. LEMAIRE, G. HAIAT, P. PIVONKA, and V. SANSALONE
Bone orthotropic remodeling as a thermodynamically-driven evolution
published pages: , ISSN: 0219-5194, DOI:
Journal of mechanics in medicine and biology 2019-11-07
2017 Lucas Colabella, Adrián P. Cisilino, Guillaume Häiat, Piotr Kowalczyk
Mimetization of the elastic properties of cancellous bone via a parameterized cellular material
published pages: 1485-1502, ISSN: 1617-7959, DOI: 10.1007/s10237-017-0901-y
Biomechanics and Modeling in Mechanobiology 16/5 2019-06-18
2018 Romain Bosc, Antoine Tijou, Giuseppe Rosi, Vu-Hieu Nguyen, Jean-Paul Meningaud, Philippe Hernigou, Charles-Henri Flouzat-Lachaniette, Guillaume Haiat
Influence of soft tissue in the assessment of the primary fixation of acetabular cup implants using impact analyses
published pages: 7-13, ISSN: 0268-0033, DOI: 10.1016/j.clinbiomech.2018.03.013
Clinical Biomechanics 55 2019-06-18
2017 Vu-Hieu Nguyen, Giuseppe Rosi, Salah Naili, Adrien Michel, Maria-Letizia Raffa, Romain Bosc, Jean-Paul Meningaud, Christine Chappard, Naoki Takano, Guillaume Haiat
Influence of anisotropic bone properties on the biomechanical behavior of the acetabular cup implant: a multiscale finite element study
published pages: 1312-1325, ISSN: 1025-5842, DOI: 10.1080/10255842.2017.1357703
Computer Methods in Biomechanics and Biomedical Engineering 20/12 2019-06-18
2018 I. Scala, G. Rosi, V.-H. Nguyen, R. Vayron, G. Haiat, S. Seuret, S. Jaffard, S. Naili
Ultrasonic characterization and multiscale analysis for the evaluation of dental implant stability: A sensitivity study
published pages: 37-44, ISSN: 1746-8094, DOI: 10.1016/j.bspc.2017.12.007
Biomedical Signal Processing and Control 42 2019-06-18
2016 Adrien Michel, Romain Bosc, Jean-Paul Meningaud, Philippe Hernigou, Guillaume Haiat
Assessing the Acetabular Cup Implant Primary Stability by Impact Analyses: A Cadaveric Study
published pages: e0166778, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0166778
PLOS ONE 11/11 2019-06-18
2018 Shigeaki Okumura, Vu-Hieu Nguyen, Hirofumi Taki, Guillaume Haïat, Salah Naili, Toru Sato
Rapid High-Resolution Wavenumber Extraction from Ultrasonic Guided Waves Using Adaptive Array Signal Processing
published pages: 652, ISSN: 2076-3417, DOI: 10.3390/app8040652
Applied Sciences 8/4 2019-06-18
2017 Yoshiki Nagatani, Séraphin Guipieri, Vu-Hieu Nguyen, Christine Chappard, Didier Geiger, Salah Naili, Guillaume Haїat
Three-dimensional Simulation of Quantitative Ultrasound in Cancellous Bone Using the Echographic Response of a Metallic Pin
published pages: 295-312, ISSN: 0161-7346, DOI: 10.1177/0161734617698648
Ultrasonic Imaging 39/5 2019-06-18
2018 Romain Vayron, Vu-Hieu Nguyen, Benoît Lecuelle, Hugues Albini Lomami, Jean-Paul Meningaud, Romain Bosc, Guillaume Haiat
Comparison of Resonance Frequency Analysis and of Quantitative Ultrasound to Assess Dental Implant Osseointegration
published pages: 1397, ISSN: 1424-8220, DOI: 10.3390/s18051397
Sensors 18/5 2019-06-18
2018 Antoine Tijou, Giuseppe Rosi, Philippe Hernigou, Charles-Henri Flouzat-Lachaniette, Guillaume Haïat
Ex Vivo Evaluation of Cementless Acetabular Cup Stability Using Impact Analyses with a Hammer Instrumented with Strain Sensors
published pages: 62, ISSN: 1424-8220, DOI: 10.3390/s18010062
Sensors 18/2 2019-06-18
2018 Romain Vayron, Vu-Hieu Nguyen, Benoît Lecuelle, Guillaume Haiat
Evaluation of dental implant stability in bone phantoms: Comparison between a quantitative ultrasound technique and resonance frequency analysis
published pages: 470-478, ISSN: 1523-0899, DOI: 10.1111/cid.12622
Clinical Implant Dentistry and Related Research 20/4 2019-06-06
2018 Antoine Tijou, Giuseppe Rosi, Romain Vayron, Hugues Albini Lomami, Philippe Hernigou, Charles-Henri Flouzat-Lachaniette, Guillaume Haïat
Monitoring cementless femoral stem insertion by impact analyses: An in vitro study
published pages: 102-108, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2018.08.009
Journal of the Mechanical Behavior of Biomedical Materials 88 2019-06-06
2018 Yoann Hériveaux, Vu-Hieu Nguyen, Guillaume Haïat
Reflection of an ultrasonic wave on the bone-implant interface: A numerical study of the effect of the multiscale roughness
published pages: 488-499, ISSN: 0001-4966, DOI: 10.1121/1.5046524
The Journal of the Acoustical Society of America 144/1 2019-06-06
2019 D. Rittel, A. Dorogoy, G. Haïat, K. Shemtov-Yona
Resonant frequency analysis of dental implants
published pages: 65-74, ISSN: 1350-4533, DOI: 10.1016/j.medengphy.2019.02.008
Medical Engineering & Physics 66 2019-06-06
2019 Heriveaux Y, Nguyen VH, Brailovski V., Gorny C., Haiat G
Reflection of an ultrasonic wave on the bone-implant interface: effect of the roughness parameters in press
published pages: , ISSN: 0001-4966, DOI:
J Acoust Soc Am 2019-06-06

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