Explore the words cloud of the ICaRO project. It provides you a very rough idea of what is the project "ICaRO" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||173˙076 €|
|EC max contribution||173˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-06-13 to 2018-06-12|
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|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||173˙076.00|
Our understanding of ion channel operation is limited to inferences based on functional data and to static snapshots of their structures where they are available. Cyclic nucleotide-modulated channels and calcium-activated K channels play crucial roles in a myriad of physiological processes ranging from signal transduction to neuronal excitability. The binding of ligands to specialized intracellular domains modulates the opening/closing (gating) equilibrium of these channels. Both the high resolution structures - in open and closed conformation - of these channels and the precise mechanism of ligand-mediated channel activation are unknown. The present proposal aims to understand the mechanism of ion channel modulation by ligands. To accomplish this goal we will utilize prokaryotic homologues of these channels reconstituted in artificial membranes. High-speed atomic force microscopy (HS-AFM) will allow us to directly observe individual ion channel molecules in action at high spatiotemporal resolution and in physiological conditions. Through UV-laser pulses caged ligands (caged-Ca2 or caged-cAMP) will be liberated during HS-AFM imaging and the conformational changes associated to ligand binding monitored in real time. Differences between liganded and unliganded channel structures will provide insight into the mechanism of ligand gating. The obtained data will be compared to single channel current recordings under comparable conditions.
|year||authors and title||journal||last update|
Luisa M. R. Napolitano, Arin Marchesi, Alex Rodriguez, Matteo De March, Silvia Onesti, Alessandro Laio, Vincent Torre
The permeation mechanism of organic cations through a CNG mimic channel
published pages: e1006295, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006295
|PLOS Computational Biology 14/8||2019-06-13|
Fidan Sumbul, Arin Marchesi, Hirohide Takahashi, Simon Scheuring, Felix Rico
High-Speed Force Spectroscopy for Single Protein Unfolding
published pages: 243-264, ISSN: , DOI: 10.1007/978-1-4939-8591-3_15
Francesca Zuttion, Lorena Redondo-Morata, Arin Marchesi, Ignacio Casuso
High-Resolution and High-Speed Atomic Force Microscope Imaging
published pages: 181-200, ISSN: , DOI: 10.1007/978-1-4939-8591-3_11
Fidan Sumbul, Arin Marchesi, Felix Rico
History, rare, and multiple events of mechanical unfolding of repeat proteins
published pages: 123335, ISSN: 0021-9606, DOI: 10.1063/1.5013259
|The Journal of Chemical Physics 148/12||2019-06-13|
Arin Marchesi, Xiaolong Gao, Ricardo Adaixo, Jan Rheinberger, Henning Stahlberg, Crina Nimigean, Simon Scheuring
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06414-8
|Nature Communications 9/1||2019-04-03|
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