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moreRNA SIGNED

Modification and regulation of coding and non-coding RNA pathways

Total Cost €

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EC-Contrib. €

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Partnership

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Project "moreRNA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET REGENSBURG 

Organization address
address: UNIVERSITATSSTRASSE 31
city: REGENSBURG
postcode: 93053
website: http://www.uni-regensburg.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.uni-regensburg.de/biologie-vorklinische-medizin/biochemie-1/
 Total cost 1˙998˙316 €
 EC max contribution 1˙998˙316 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET REGENSBURG DE (REGENSBURG) coordinator 1˙998˙316.00

Map

 Project objective

Coding and non-coding RNAs are regulated at numerous levels. For example, microRNA (miRNA) expression can be influenced at various steps of biosynthesis. Furthermore, it has been reported that direct RNA methylation events can also affect gene expression in many different organisms and systems. The aim of this project is to identify and characterize factors that affect the maturation of miRNAs. We will employ biochemical pull down assays to isolate specific binding partners of different miRNA species. We will analyze the physiological role of these factors using molecular or cell biological approaches. Molecular details of pre-miRNA-protein interactions will be investigated by x-ray crystallography. In addition, we will decipher the role of the m6A methylation pathway on the regulation of coding and non-coding RNAs. Writers, readers and erasers of this modification have been identified. However, not much is known about the composition of specific protein complexes as well as the atomic structure of these factors. Thus, we will functionally and structurally characterize known and putative novel factors of the m6A methylation pathway in human cells. Furthermore, using our biochemical pull down approach employed for the identification of pre-miRNA processing factors, we will identify reader proteins of several types of RNA modification that have not been investigated so far. The proposed project will elucidate the regulation of gene expression by small RNAs or direct RNA methylation and will add so far unknown components to these important regulatory pathways.

 Publications

year authors and title journal last update
List of publications.
2017 Thomas Treiber, Nora Treiber, Uwe Plessmann, Simone Harlander, Julia-Lisa Daiß, Norbert Eichner, Gerhard Lehmann, Kevin Schall, Henning Urlaub, Gunter Meister
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis
published pages: 270-284.e13, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.03.014
Molecular Cell 66/2 2019-06-18
2018 Dmytro Ustianenko, Hua-Sheng Chiu, Thomas Treiber, Sebastien M. Weyn-Vanhentenryck, Nora Treiber, Gunter Meister, Pavel Sumazin, Chaolin Zhang
LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs
published pages: 271-283.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.06.029
Molecular Cell 71/2 2019-05-22
2018 Thomas Treiber, Nora Treiber, Gunter Meister
Author Correction: Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
published pages: 808-808, ISSN: 1471-0072, DOI: 10.1038/s41580-018-0070-6
Nature Reviews Molecular Cell Biology 19/12 2019-03-06
2018 Eva Schöller, Franziska Weichmann, Thomas Treiber, Sam Ringle, Nora Treiber, Andrew Flatley, Regina Feederle, Astrid Bruckmann, Gunter Meister
Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex
published pages: 499-512, ISSN: 1355-8382, DOI: 10.1261/rna.064063.117
RNA 24/4 2019-03-06

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