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GLYCANLIPO SIGNED

Selective glycan recognition using molecularly imprinted liposomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GLYCANLIPO project word cloud

Explore the words cloud of the GLYCANLIPO project. It provides you a very rough idea of what is the project "GLYCANLIPO" about.

biomarkers    sharply    carbohydrate    binding    bilayer    structures    therapies    tumour    diseases    clinical    liposome    multiple    neurodegenerative    sensitivity    types    polymerizable    discriminate    functionalized    affinity    opportunity    daunting    heart    deficiencies    complexity    molecular    immune    meeting    owing    proteoglycans    innovative    interactions    whilst    glycolipids    kinds    glycoproteins    economic    lipid    biological    assisting    cancers    glycans    sialylation    receptors    lipids    specificity    membrane    disorders    diversity    source    synthetic    fellowship    imprinting    biantennary    directive    form    detection    contain    glycan    carbohydrates    hereditary    selective    first    cancer    er    fucosylation    impacts    training    inherent    carry    time    tools    exquisite    societal    cardiovascular    sites    molecules    lateral    glycoconjugates    free    accurate    biophysics    fluid    recognition    surfaces    multivalent    exceptional    platforms    mobility   

Project "GLYCANLIPO" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-03   to  2020-12-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 195˙454.00

Map

 Project objective

Glycans, also referred to as carbohydrates, occur as simple or complex structures in free form or in many different kinds of glycoconjugates, which include glycoproteins, glycolipids and proteoglycans. Glycans carry information in biological systems that make them an important source of biomarkers for wide range of diseases, including neurodegenerative diseases, hereditary disorders, immune deficiencies, cardiovascular diseases and many types of cancers. While recognition of glycans by other molecules with high affinity and exquisite specificity is at the heart of the early and accurate detection of such diseases, selective glycan recognition remains a daunting task due to their inherent diversity and complexity. The aim of this innovative Fellowship is to use concepts and tools from lipid membrane biophysics and molecular imprinting to provide synthetic recognition platforms with high sensitivity and specificity for glycans. For the first time, we will exploit (i) lateral mobility of polymerizable lipids functionalized with carbohydrate receptors in a fluid bilayer and, (ii) multivalent interactions between the target glycan and multiple carbohydrate receptors to produce liposome surfaces with high affinity binding sites that can sharply discriminate between different glycans, including tumour-associated glycans that contain sialylation, fucosylation and biantennary structures. Owing to great clinical importance of cancer-associated glycans for early detection and targeted therapies, the work will have significant economic and societal impacts, assisting the meeting of EU Directive requirements whilst providing an exceptional training opportunity for the ER.

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The information about "GLYCANLIPO" are provided by the European Opendata Portal: CORDIS opendata.

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