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GLYCANLIPO SIGNED

Selective glycan recognition using molecularly imprinted liposomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GLYCANLIPO project word cloud

Explore the words cloud of the GLYCANLIPO project. It provides you a very rough idea of what is the project "GLYCANLIPO" about.

daunting    kinds    glycolipids    lateral    hereditary    er    societal    interactions    biophysics    cardiovascular    fellowship    receptors    heart    deficiencies    recognition    multiple    detection    binding    exceptional    tumour    meeting    time    biological    owing    types    directive    clinical    immune    source    assisting    innovative    inherent    synthetic    multivalent    carry    fucosylation    first    exquisite    functionalized    structures    liposome    diseases    surfaces    proteoglycans    opportunity    fluid    cancer    bilayer    biantennary    membrane    lipids    sensitivity    affinity    molecules    carbohydrate    diversity    contain    tools    cancers    carbohydrates    sialylation    polymerizable    neurodegenerative    disorders    lipid    molecular    biomarkers    mobility    economic    sharply    glycoconjugates    glycan    form    selective    specificity    accurate    impacts    free    sites    glycoproteins    platforms    imprinting    whilst    training    therapies    discriminate    complexity    glycans   

Project "GLYCANLIPO" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-12-03   to  2020-12-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 195˙454.00

Map

 Project objective

Glycans, also referred to as carbohydrates, occur as simple or complex structures in free form or in many different kinds of glycoconjugates, which include glycoproteins, glycolipids and proteoglycans. Glycans carry information in biological systems that make them an important source of biomarkers for wide range of diseases, including neurodegenerative diseases, hereditary disorders, immune deficiencies, cardiovascular diseases and many types of cancers. While recognition of glycans by other molecules with high affinity and exquisite specificity is at the heart of the early and accurate detection of such diseases, selective glycan recognition remains a daunting task due to their inherent diversity and complexity. The aim of this innovative Fellowship is to use concepts and tools from lipid membrane biophysics and molecular imprinting to provide synthetic recognition platforms with high sensitivity and specificity for glycans. For the first time, we will exploit (i) lateral mobility of polymerizable lipids functionalized with carbohydrate receptors in a fluid bilayer and, (ii) multivalent interactions between the target glycan and multiple carbohydrate receptors to produce liposome surfaces with high affinity binding sites that can sharply discriminate between different glycans, including tumour-associated glycans that contain sialylation, fucosylation and biantennary structures. Owing to great clinical importance of cancer-associated glycans for early detection and targeted therapies, the work will have significant economic and societal impacts, assisting the meeting of EU Directive requirements whilst providing an exceptional training opportunity for the ER.

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The information about "GLYCANLIPO" are provided by the European Opendata Portal: CORDIS opendata.

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