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GIANTSYN SIGNED

Biophysics and circuit function of a giant cortical glutamatergic synapse

Total Cost €

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EC-Contrib. €

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Project "GIANTSYN" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 2˙677˙500 €
 EC max contribution 2˙677˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 2˙677˙500.00

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 Project objective

A fundamental question in neuroscience is how the biophysical properties of synapses shape higher network computations. The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is the ideal synapse to address this question. This synapse is accessible to presynaptic recording, due to its large size, allowing a rigorous investigation of the biophysical mechanisms of transmission and plasticity. Furthermore, this synapse is placed in the center of a memory circuit, and several hypotheses about its network function have been generated. However, even basic properties of this key communication element remain enigmatic. The ambitious goal of the current proposal, GIANTSYN, is to understand the hippocampal mossy fiber synapse at all levels of complexity. At the subcellular level, we want to elucidate the biophysical mechanisms of transmission and synaptic plasticity in the same depth as previously achieved at peripheral and brainstem synapses, classical synaptic models. At the network level, we want to unravel the connectivity rules and the in vivo network function of this synapse, particularly its role in learning and memory. To reach these objectives, we will combine functional and structural approaches. For the analysis of synaptic transmission and plasticity, we will combine direct preand postsynaptic patch-clamp recording and high-pressure freezing electron microscopy. For the analysis of connectivity and network function, we will use transsynaptic labeling and in vivo electrophysiology. Based on the proposed interdisciplinary research, the hippocampal mossy fiber synapse could become the first synapse in the history of neuroscience in which we reach complete insight into both synaptic biophysics and network function. In the long run, the results may open new perspectives for the diagnosis and treatment of brain diseases in which mossy fiber transmission, plasticity, or connectivity are impaired.

 Publications

year authors and title journal last update
List of publications.
2016 Nicholas P Vyleta, Carolina Borges-Merjane, Peter Jonas
Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.17977
eLife 5 2020-03-20
2017 Chong Chen, Rachel Satterfield, Samuel M. Young, Peter Jonas
Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses
published pages: 2082-2089, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.10.122
Cell Reports 21/8 2020-03-20
2018 Hua Hu, Fabian C. Roth, David Vandael, Peter Jonas
Complementary Tuning of Na + and K + Channel Gating Underlies Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons
published pages: 156-165.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.02.024
Neuron 98/1 2020-03-20

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The information about "GIANTSYN" are provided by the European Opendata Portal: CORDIS opendata.

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