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Bio-Inspired Self-Assembled Supramolecular Organic Nanostructures

Total Cost €


EC-Contrib. €






Project "BISON" data sheet

The following table provides information about the project.


Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website
 Total cost 3˙003˙125 €
 EC max contribution 3˙003˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 3˙003˙125.00


 Project objective

Peptide building blocks serve as very attractive bio-inspired elements in nanotechnology owing to their controlled self-assembly, inherent biocompatibility, chemical versatility, biological recognition abilities and facile synthesis. We have demonstrated the ability of remarkably simple aromatic peptides to form well-ordered nanostructures of exceptional physical properties. By taking inspiration from the minimal recognition modules used by nature to mediate coordinated processes of self-assembly, we have developed building blocks that form well-ordered nanostructures. The compact design of the building blocks, and therefore, the unique structural organization, resulted in metallic-like Young's modulus, blue luminescence due to quantum confinement, and notable piezoelectric properties. The goal of this proposal is to develop two new fronts for bio-inspired building block repertoire along with co-assembly to provide new avenues for organic nanotechnology. This will combine our vast experience in the assembly of aromatic peptides together with additional structural modules from nature. The new entities will be developed by exploiting the design principles of small aromatic building blocks to arrive at the smallest possible module that form super helical assembly based on the coiled coil motifs and establishing peptide nucleic acids based systems to combine the worlds of peptide and DNA nanotechnologies. The proposed research will combine extensive design and synthesis effort to provide a very diverse collection of novel buildings blocks and determination of their self-assembly process, followed by broad chemical, physical, and biological characterization of the nanostructures. Furthermore, effort will be made to establish supramolecular co-polymer systems to extend the morphological control of the assembly process. The result of the project will be a large and defined collection of novel chemical entities that will help reshape the field of bioorganic nanotechnology.


year authors and title journal last update
List of publications.
2017 Sayanti Brahmachari, Zohar A. Arnon, Anat Frydman-Marom, Ehud Gazit, Lihi Adler-Abramovich
Diphenylalanine as a Reductionist Model for the Mechanistic Characterization of β - Amyloid Modulators
published pages: 5960-5969, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b01662
ACS Nano 11/6 2019-06-13
2016 Tom Guterman, Micha Kornreich, Avigail Stern, Lihi Adler-Abramovich, Danny Porath, Roy Beck, Linda J. W. Shimon, Ehud Gazit
Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
published pages: 13482, ISSN: 2041-1723, DOI: 10.1038/ncomms13482
Nature Communications 7 2019-06-13
2017 Kai Tao, Bin Xue, Samuel Frere, Inna Slutsky, Yi Cao, Wei Wang, Ehud Gazit
Multiporous Supramolecular Microspheres for Artificial Photosynthesis
published pages: 4454-4460, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.7b00966
Chemistry of Materials 29/10 2019-06-13
2017 Kai Tao, Pandeeswar Makam, Ruth Aizen, Ehud Gazit
Self-assembling peptide semiconductors
published pages: eaam9756, ISSN: 0036-8075, DOI: 10.1126/science.aam9756
Science 358/6365 2019-06-13
2018 Kai Tao, Zhen Fan, Leming Sun, Pandeeswar Makam, Zhen Tian, Mark Ruegsegger, Shira Shaham-Niv, Derek Hansford, Ruth Aizen, Zui Pan, Scott Galster, Jianjie Ma, Fan Yuan, Mingsu Si, Songnan Qu, Mingjun Zhang, Ehud Gazit, Junbai Li
Quantum confined peptide assemblies with tunable visible to near-infrared spectral range
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05568-9
Nature Communications 9/1 2019-05-03
2017 Michal Pellach, Sudipta Mondal, Karl Harlos, Deni Mance, Marc Baldus, Ehud Gazit, Linda J. W. Shimon
A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure
published pages: 3252-3255, ISSN: 1433-7851, DOI: 10.1002/anie.201609877
Angewandte Chemie International Edition 56/12 2019-05-03
2017 Sílvia Pujals, Kai Tao, Adrià Terradellas, Ehud Gazit, Lorenzo Albertazzi
Studying structure and dynamics of self-assembled peptide nanostructures using fluorescence and super resolution microscopy
published pages: 7294-7297, ISSN: 1359-7345, DOI: 10.1039/c7cc02176c
Chemical Communications 53/53 2019-03-07
2016 Zohar A. Arnon, Andreas Vitalis, Aviad Levin, Thomas C. T. Michaels, Amedeo Caflisch, Tuomas P. J. Knowles, Lihi Adler-Abramovich, Ehud Gazit
Dynamic microfluidic control of supramolecular peptide self-assembly
published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms13190
Nature Communications 7/1 2019-03-07
2018 Ruth Aizen, Kai Tao, Sigal Rencus-Lazar, Ehud Gazit
Functional metabolite assemblies—a review
published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4217-3
Journal of Nanoparticle Research 20/5 2019-03-07
2017 Sudipta Mondal, Maxim Varenik, Daniel Nir Bloch, Yoav Atsmon-Raz, Guy Jacoby, Lihi Adler-Abramovich, Linda J.W. Shimon, Roy Beck, Yifat Miller, Oren Regev, Ehud Gazit
A minimal length rigid helical peptide motif allows rational design of modular surfactants
published pages: 14018, ISSN: 2041-1723, DOI: 10.1038/ncomms14018
Nature Communications 8 2019-03-07
2018 Noam Brown, Jiangtao Lei, Chendi Zhan, Linda J. W. Shimon, Lihi Adler-Abramovich, Guanghong Wei, Ehud Gazit
Structural Polymorphism in a Self-Assembled Tri-Aromatic Peptide System
published pages: 3253-3262, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b07723
ACS Nano 12/4 2019-03-07
2018 Zohar A. Arnon, Dorothea Pinotsi, Matthias Schmidt, Sharon Gilead, Tom Guterman, Aditya Sadhanala, Shahab Ahmad, Aviad Levin, Paul Walther, Clemens F. Kaminski, Marcus Fändrich, Gabriele S. Kaminski Schierle, Lihi Adler-Abramovich, Linda J. W. Shimon, Ehud Gazit
Opal-like Multicolor Appearance of Self-Assembled Photonic Array
published pages: 20783-20789, ISSN: 1944-8244, DOI: 10.1021/acsami.8b04912
ACS Applied Materials & Interfaces 10/24 2019-03-07
2017 Or Berger, Ehud Gazit
Molecular self-assembly using peptide nucleic acids
published pages: e22930, ISSN: 0006-3525, DOI: 10.1002/bip.22930
Biopolymers 108/1 2019-03-07
2017 Gang Wei, Zhiqiang Su, Nicholas P. Reynolds, Paolo Arosio, Ian W. Hamley, Ehud Gazit, Raffaele Mezzenga
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
published pages: 4661-4708, ISSN: 0306-0012, DOI: 10.1039/c6cs00542j
Chemical Society Reviews 46/15 2019-03-07
2018 Pandeeswar Makam, Ehud Gazit
Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology
published pages: 3406-3420, ISSN: 0306-0012, DOI: 10.1039/c7cs00827a
Chemical Society Reviews 47/10 2019-03-07

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