Explore the words cloud of the GoCADiSC project. It provides you a very rough idea of what is the project "GoCADiSC" about.
The following table provides information about the project.
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
|Coordinator Country||Netherlands [NL]|
|Total cost||2˙497˙125 €|
|EC max contribution||2˙497˙125 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS||NL (AMSTERDAM)||coordinator||2˙497˙125.00|
'The spatial architecture of mammalian interphase chromosomes, each consisting of tens of megabases of DNA, poses an intriguing topological problem and is relevant for various nuclear functions. A major challenge is that chromosome architecture exhibits substantial stochastic cell-to-cell variation. To unravel the principles of chromosome organization, new single-cell genome-wide approaches that capture the intrinsic variability are needed. Interphase chromosomes interact extensively with relatively fixed nuclear 'landmarks' such as the nuclear lamina and nucleoli, posing considerable restraints to the spatial organization of chromosomes. For example, about one-third of the mammalian genome interacts with the nuclear lamina. We have recently developed two complementary methods to (i) visualize and track landmark – genome interactions in living cells, and (ii) generate genome-wide maps of these interactions in single cells. These new methods offer unique opportunities to unravel chromosome architecture, taking cell-to-cell variation and dynamics into account. Here I propose to take an integrative approach to study genome – landmark interactions in single mammalian cells. We will: (1) Extend our single-cell methods to visualize and map interactions of the genome with multiple landmarks, and with substantially enhanced genomic and temporal resolution; (2) Elucidate the dynamics and diversity of chromosome architecture in single cells, including differentiating cells; (3) Identify cis-determinants of chromosome - landmark interactions through systematic perturbation of linear chromosome organization, both by targeted mutagenesis and by a random scrambling approach; (4) elucidate the role of various proteins in the global and local control of single-cell dynamics of chromosome organization. These tightly linked approaches will provide detailed understanding of the dynamic architecture of chromosomes in individual cells, and yield new methods and resources. '
|year||authors and title||journal||last update|
Joris van Arensbergen, Ludo Pagie, Vincent D. FitzPatrick, Marcel de Haas, Marijke P. Baltissen, Federico Comoglio, Robin H. van der Weide, Hans Teunissen, Urmo VÃµsa, Lude Franke, Elzo de Wit, Michiel Vermeulen, Harmen J. Bussemaker, Bas van Steensel
High-throughput identification of human SNPs affecting regulatory element activity
published pages: 1160-1169, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0455-2
|Nature Genetics 51/7||2019-10-07|
Eva K. Brinkman, Tao Chen, Marcel de Haas, Hanna A. Holland, Waseem Akhtar, Bas van Steensel
Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks
published pages: 801-813.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.04.016
|Molecular Cell 70/5||2019-05-10|
Eva K Brinkman, Arne N Kousholt, Tim Harmsen, Christ Leemans, Tao Chen, Jos Jonkers, Bas vanÂ Steensel
Easy quantification of template-directed CRISPR/Cas9 editing
published pages: e58-e58, ISSN: 0305-1048, DOI: 10.1093/nar/gky164
|Nucleic Acids Research 46/10||2019-05-10|
Bas van Steensel
Scientific honesty and publicly shared lab notebooks
published pages: e46866, ISSN: 1469-221X, DOI: 10.15252/embr.201846866
|EMBO reports 19/10||2019-05-10|
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The information about "GOCADISC" are provided by the European Opendata Portal: CORDIS opendata.