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MechBiolRep SIGNED

Mechanobiology of Bovine Reproduction

Total Cost €

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EC-Contrib. €

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Partnership

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 MechBiolRep project word cloud

Explore the words cloud of the MechBiolRep project. It provides you a very rough idea of what is the project "MechBiolRep" about.

complemented    zona    quiescent    embryo    compliance    embryogenesis    microenvironments    demand    profiling    exact    similarly    developmental    decade    reproduction    follicular    disease    mature    pellucida    clear    course    entire    regulation    external    dairy    decreasing    serve    renewable    assisted    stresses    manner    insatiable    quality    soluble    premise    toward    preimplantation    signalling    freshly    follicle    insights    global    insulated    physical    causes    maturation    species    supporting    mimicking    characterizing    ovaries    mammals    bovine    employ    biophysical    characterization    cortical    follicles    industry    stored    fates    showing    cow    oocyte    distinctive    specialized    mechanistic    reserve    mechanobiology    relies    toolbox    extracellular    generate    regulated    reproductive    regeneration    paracrine    ovarian    potent    primordial    environments    vitro    surrounded    tightly    36    endocrine    niche    cell    surge    fertility    molecular    progressively    surroundings    mechanical    regulators    oocytes    biology    declining    computational    inputs    microenvironment    technologies   

Project "MechBiolRep" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙500˙000.00

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 Project objective

The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing.

In mammals, the ovarian reserve of oocytes stored within quiescent primordial follicles is non-renewable. Oocyte develop and mature within distinctive follicular microenvironments under tightly regulated molecular and physical conditions. Similarly, preimplantation embryo development is supported within a specialized microenvironment that is surrounded by the zona pellucida and insulated from external soluble and mechanical inputs. Characterizing and understanding these environments and how they affect reproductive processes is a key toward improving assisted reproductive technologies in bovine species.

Our premise is that molecular characterization of endocrine and paracrine signalling pathways must be complemented with understanding the mechanical regulation of reproductive biology. This premise is supported by recent finding showing that physical stresses and the mechanical compliance of the extracellular surroundings serve as potent regulators of cell fates in regeneration processes, development, and disease.

I propose to employ a biophysical and computational toolbox to study the mechanobiology of reproduction with application to bovine embryo-based technologies. By mimicking the mechanical properties of the ovarian cortical niche, which I will characterize using freshly derived ovaries, I will design an in vitro system for supporting follicle growth. Mechanical profiling of the entire developmental course from oocyte maturation to preimplantation embryogenesis will generate mechanistic insights into the physical regulation of reproductive processes.

 Publications

year authors and title journal last update
List of publications.
2020 Oren Wintner, Nivi Hirsch‐Attas, Miriam Schlossberg, Fani Brofman, Roy Friedman, Meital Kupervaser, Danny Kitsberg, Amnon Buxboim
A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin
published pages: 1901222, ISSN: 2198-3844, DOI: 10.1002/advs.201901222
Advanced Science 2020-03-24

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