Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. mechbiolrep

MechBiolRep SIGNED

Mechanobiology of Bovine Reproduction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 MechBiolRep project word cloud

Explore the words cloud of the MechBiolRep project. It provides you a very rough idea of what is the project "MechBiolRep" about.

oocyte    distinctive    fertility    global    freshly    quality    decade    manner    causes    clear    characterizing    declining    surrounded    physical    characterization    developmental    potent    technologies    pellucida    embryogenesis    progressively    mechanobiology    mechanical    regulation    insights    microenvironment    follicle    regeneration    demand    niche    complemented    regulators    environments    similarly    cell    extracellular    specialized    bovine    biology    reproductive    entire    external    surge    serve    paracrine    tightly    surroundings    embryo    quiescent    molecular    stresses    regulated    cortical    generate    ovarian    decreasing    inputs    endocrine    disease    showing    insulated    follicular    employ    course    biophysical    signalling    maturation    oocytes    mature    relies    preimplantation    mechanistic    reserve    follicles    insatiable    profiling    36    fates    zona    microenvironments    industry    computational    compliance    reproduction    supporting    toward    dairy    premise    assisted    stored    toolbox    species    soluble    primordial    cow    renewable    exact    mimicking    ovaries    vitro    mammals   

Project "MechBiolRep" data sheet

The following table provides information about the project.

Coordinator		 THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙500˙000.00

Map

 Project objective

The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing.

In mammals, the ovarian reserve of oocytes stored within quiescent primordial follicles is non-renewable. Oocyte develop and mature within distinctive follicular microenvironments under tightly regulated molecular and physical conditions. Similarly, preimplantation embryo development is supported within a specialized microenvironment that is surrounded by the zona pellucida and insulated from external soluble and mechanical inputs. Characterizing and understanding these environments and how they affect reproductive processes is a key toward improving assisted reproductive technologies in bovine species.

Our premise is that molecular characterization of endocrine and paracrine signalling pathways must be complemented with understanding the mechanical regulation of reproductive biology. This premise is supported by recent finding showing that physical stresses and the mechanical compliance of the extracellular surroundings serve as potent regulators of cell fates in regeneration processes, development, and disease.

I propose to employ a biophysical and computational toolbox to study the mechanobiology of reproduction with application to bovine embryo-based technologies. By mimicking the mechanical properties of the ovarian cortical niche, which I will characterize using freshly derived ovaries, I will design an in vitro system for supporting follicle growth. Mechanical profiling of the entire developmental course from oocyte maturation to preimplantation embryogenesis will generate mechanistic insights into the physical regulation of reproductive processes.

 Publications

year authors and title journal last update
List of publications.
2020 Oren Wintner, Nivi Hirsch‐Attas, Miriam Schlossberg, Fani Brofman, Roy Friedman, Meital Kupervaser, Danny Kitsberg, Amnon Buxboim
A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin
published pages: 1901222, ISSN: 2198-3844, DOI: 10.1002/advs.201901222 		Advanced Science 2020-03-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MECHBIOLREP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MECHBIOLREP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

Antiseptic-Wax (2018)

Bioinspired superhydrophbic wax surfaces to eliminate biofilm formation in the food industry

Read More