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MechBiolRep SIGNED

Mechanobiology of Bovine Reproduction

Total Cost €


EC-Contrib. €






 MechBiolRep project word cloud

Explore the words cloud of the MechBiolRep project. It provides you a very rough idea of what is the project "MechBiolRep" about.

cow    freshly    supporting    potent    relies    tightly    characterizing    36    declining    microenvironments    embryo    mechanical    surge    signalling    profiling    follicles    characterization    decade    toolbox    physical    developmental    causes    demand    cell    pellucida    renewable    cortical    oocyte    insights    fertility    mechanistic    entire    specialized    computational    exact    stored    inputs    maturation    serve    manner    oocytes    clear    stresses    regulated    quiescent    disease    premise    decreasing    employ    dairy    species    vitro    microenvironment    regulation    fates    environments    paracrine    bovine    endocrine    surrounded    ovaries    distinctive    toward    embryogenesis    course    surroundings    reproduction    zona    assisted    molecular    reserve    mimicking    regeneration    extracellular    biophysical    reproductive    ovarian    mature    generate    insulated    mammals    compliance    mechanobiology    similarly    follicular    industry    regulators    follicle    insatiable    primordial    technologies    global    niche    preimplantation    complemented    showing    biology    progressively    external    quality    soluble   

Project "MechBiolRep" data sheet

The following table provides information about the project.


Organization address
postcode: 91904

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing.

In mammals, the ovarian reserve of oocytes stored within quiescent primordial follicles is non-renewable. Oocyte develop and mature within distinctive follicular microenvironments under tightly regulated molecular and physical conditions. Similarly, preimplantation embryo development is supported within a specialized microenvironment that is surrounded by the zona pellucida and insulated from external soluble and mechanical inputs. Characterizing and understanding these environments and how they affect reproductive processes is a key toward improving assisted reproductive technologies in bovine species.

Our premise is that molecular characterization of endocrine and paracrine signalling pathways must be complemented with understanding the mechanical regulation of reproductive biology. This premise is supported by recent finding showing that physical stresses and the mechanical compliance of the extracellular surroundings serve as potent regulators of cell fates in regeneration processes, development, and disease.

I propose to employ a biophysical and computational toolbox to study the mechanobiology of reproduction with application to bovine embryo-based technologies. By mimicking the mechanical properties of the ovarian cortical niche, which I will characterize using freshly derived ovaries, I will design an in vitro system for supporting follicle growth. Mechanical profiling of the entire developmental course from oocyte maturation to preimplantation embryogenesis will generate mechanistic insights into the physical regulation of reproductive processes.


year authors and title journal last update
List of publications.
2020 Oren Wintner, Nivi Hirsch‐Attas, Miriam Schlossberg, Fani Brofman, Roy Friedman, Meital Kupervaser, Danny Kitsberg, Amnon Buxboim
A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin
published pages: 1901222, ISSN: 2198-3844, DOI: 10.1002/advs.201901222
Advanced Science 2020-03-24

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The information about "MECHBIOLREP" are provided by the European Opendata Portal: CORDIS opendata.

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