DNA-TRAP

DNA-TRAP – Delivery of Nucleic Acid-Based Therapeutics for the TReatment of Antibiotic-Resistant Pathogens

Coordinatore	PROCARTA BIOSYSTEMS LIMITED    more  Organization address address: BANKSIDE 300 PEACHMAN WAY city: NORWICH postcode: NR7 0LB contact info Titolo: Dr. Nome: Kostas Cognome: Hatzixanthis Email: send email Telefono: 447968000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙371˙031 €
EC contributo	2˙371˙031 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2017-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PROCARTA BIOSYSTEMS LIMITED  Organization address address: BANKSIDE 300 PEACHMAN WAY city: NORWICH postcode: NR7 0LB contact info Titolo: Dr. Nome: Kostas Cognome: Hatzixanthis Email: send email Telefono: 447968000000	UK (NORWICH)	coordinator	760˙133.80
2	UNIVERSITY OF EAST ANGLIA  Organization address address: EARLHAM ROAD city: NORWICH postcode: NR4 7TJ contact info Titolo: Mrs. Nome: Yvonne Cognome: Kirkham Email: send email Telefono: 441604000000	UK (NORWICH)	participant	647˙597.25
3	CONSORZIO INTERUNIVERSITARIO PER LO SVILUPPO DEI SISTEMI A GRANDE INTERFASE  Organization address address: VIA DELLA LASTRUCCIA-SESTO FIORENTINO 3 city: FIRENZE postcode: 50019 contact info Titolo: Dr. Nome: Debora Cognome: Berti Email: send email Telefono: +39 0554573038	IT (FIRENZE)	participant	496˙734.84
4	NANOVECTOR SRL  Organization address address: VIA LIVORNO 60 city: TORINO postcode: 10144 contact info Titolo: Mr. Nome: Paolo Cognome: Gasco Email: send email Telefono: +39 0112258921	IT (TORINO)	participant	466˙565.10

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 Obiettivo del progetto (Objective)

'Antimicrobial agents, such as antibiotics, have dramatically reduced the number of deaths from infectious diseases over the last 70 years. However, through overuse and misuse of these agents, many micro-organisms have developed antimicrobial resistance. Oligonucleotide therapeutics have the potential to become the new class of antibacterials capable of treating a broad range of infections. By acting on novel targets, they circumvent current resistance mechanisms and with judicious use, can suppress the rise of future resistance.

DNA-TRAP will build on a platform technology that uses proprietary nucleic acid-based Transcription Factor Decoys (TFDs) that act on novel genomic targets by capturing key regulatory proteins to block essential bacterial genes and defeat infection. Taking forward newly emerging insights and expertise that exists within each of the partners and through the mutual secondment of researchers, the project aims to develop a new class of nanoparticulate antibacterials capable of meeting the clinical challenge of drug-resistant infections such as Clostridium difficile and Pseudomonas aeruginosa.

DNA-TRAP will establish a lasting, international partnership for transfer of knowledge between Industry and Academia in the field of nanomedicine. Exchange of knowledge and expertise between the partners is key to establishing the fundamental properties of nanostructured drug delivery systems to treat bacterial infections and through this, provide the basis for building a manufacturing platform to advance the experimental therapeutic into clinical trials.

17 researchers in the field of drug development and delivery from 2 commercial (SME) and 2 non-commercial partners across 2 member states, will have the opportunity to share and acquire new complementary and multidisciplinary knowledge, through inter-sectoral and interdisciplinary exchange, allowing for the development of new solutions and the establishment of further joint research projects.'