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ChromADICT SIGNED

Chromatin Adaptations through Interactions of Chaperones in Time

Total Cost €

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EC-Contrib. €

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Partnership

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 ChromADICT project word cloud

Explore the words cloud of the ChromADICT project. It provides you a very rough idea of what is the project "ChromADICT" about.

regulate    organize    bricklayers    nucleosomes    natural    central    mice    principles    placement    mechanisms    follow    replication    considering    organization    crosstalk    centromere    variant    chaperone    pathological    biology    bridge    experimentally    plasticity    chaperones    pathology    chromatin    readout    complexes    loading    time    soluble    building    fixed    cellular    quantitative    telomeres    imaging    proteins    locus    genome    differentiation    nuclear    modules    dosage    single    animal    heterochromatin    domains    dynamic    spectrometry    degradation    highlight    escort    mass    unprecedented    adaptability    cell    models    architects    question    unravel    circuitry    developmental    selectivity    interactions    histone    adapts    designing    regulatory    multicellular    structures    underlined    decipher    commitment    landmarks    imbalances    es    roles    mark    organisms    cycle    contexts    function    series    transitions    supply    variants    repair    fundamental    engineer    regions   

Project "ChromADICT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙499˙697 €
 EC max contribution 2˙499˙697 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 2˙499˙697.00

Map

 Project objective

A central question in chromatin biology is how to organize the genome and mark specific regions with histone variants. Understanding how to establish and maintain, but also change chromatin states is a fundamental challenge. Histone chaperones, escort factors that regulate the supply, loading, and degradation of histone variants, are key in their placement at specific chromatin landmarks and bridge organization from nucleosomes to higher order structures. A series of studies have underlined chaperone-variant partner selectivity in multicellular organisms, yet recently, dosage imbalances in natural and pathological contexts highlight plasticity in these interactions. Considering known changes in histone dosage during development, one should evaluate chaperone function not as fixed modules, but as a dynamic circuitry that adapts to cellular needs during the cell cycle, replication and repair, differentiation, development and pathology. Here we propose to decipher the mechanisms enabling adaptability to natural and experimentally induced changes in the dosage of histone chaperones and variants over time. To follow new and old proteins, and control dosage, we will engineer cellular and animal models and exploit quantitative readout methods using mass spectrometry, imaging, and single-cell approaches. We will evaluate with an unprecedented level of detail the impact on i) soluble histone complexes and ii) specific chromatin landmarks (centromere, telomeres, heterochromatin and regulatory elements) and their crosstalk. We will apply this to determine the impact of these parameters during distinct developmental transitions, such as ES cell differentiation and T cell commitment in mice. We aim to define general principles for variants in nuclear organization and dynamic changes during the cell cycle/repair and in differentiation and unravel locus specific-roles of chaperones as architects and bricklayers of the genome, in designing and building specific nuclear domains.

 Publications

year authors and title journal last update
List of publications.
2017 Francisco Saavedra, Carlos Rivera, Elizabeth Rivas, Paola Merino, Daniel Garrido, Sergio Hernández, Ignasi Forné, Isabelle Vassias, Zachary A. Gurard-Levin, Iván E. Alfaro, Axel Imhof, Geneviève Almouzni, Alejandra Loyola
PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4
published pages: 11700-11710, ISSN: 0305-1048, DOI: 10.1093/nar/gkx775
Nucleic Acids Research 45/20 2020-03-06
2017 Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, Zachary A. Gurard-Levin, Guillermo A. Orsi, Iva Simeonova, Eleonore Toufektchan, Laura D. Attardi, Franck Toledo, Geneviève Almouzni
Essential role for centromeric factors following p53 loss and oncogenic transformation
published pages: 463-480, ISSN: 0890-9369, DOI: 10.1101/gad.290924.116
Genes & Development 31/5 2020-03-06
2017 David Sitbon, Katrina Podsypanina, Tejas Yadav, Geneviève Almouzni
Shaping Chromatin in the Nucleus: The Bricks and the Architects
published pages: 33753, ISSN: 0091-7451, DOI: 10.1101/sqb.2017.82.033753
Cold Spring Harbor Symposia on Quantitative Biology 2020-03-06
2018 Marie-Therese El-Daher, Nicolas Cagnard, Marine Gil, Marie Chansel Da Cruz, Claire Leveau, Fernando Sepulveda, Mohammed Zarhrate, Frédéric Tores, Patricia Legoix, Sylvain Baulande, Jean Pierre de Villartay, Geneviève Almouzni, Jean-Pierre Quivy, Alain Fischer, Geneviève de Saint Basile
Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure
published pages: , ISSN: 2056-5968, DOI: 10.1038/s41421-018-0061-y
Cell Discovery 4/1 2020-03-06
2018 Tejas Yadav, Jean-Pierre Quivy, Geneviève Almouzni
Chromatin plasticity: A versatile landscape that underlies cell fate and identity
published pages: 1332-1336, ISSN: 0036-8075, DOI: 10.1126/science.aat8950
Science 361/6409 2020-03-06
2018 Roberto Bellelli, Ondrej Belan, Valerie E. Pye, Camille Clement, Sarah L. Maslen, J. Mark Skehel, Peter Cherepanov, Genevieve Almouzni, Simon J. Boulton
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication
published pages: 112-126.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.08.043
Molecular Cell 72/1 2020-03-06
2017 Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.23474
eLife 6 2020-03-06
2018 Camille Clément, Guillermo A. Orsi, Alberto Gatto, Ekaterina Boyarchuk, Audrey Forest, Bassam Hajj, Judith Miné-Hattab, Mickaël Garnier, Zachary A. Gurard-Levin, Jean-Pierre Quivy, Geneviève Almouzni
High-resolution visualization of H3 variants during replication reveals their controlled recycling
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05697-1
Nature Communications 9/1 2020-03-06
2018 Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, Geneviève Almouzni, Didier Trono
KAP1 facilitates reinstatement of heterochromatin after DNA replication
published pages: 8788-8802, ISSN: 0305-1048, DOI: 10.1093/nar/gky580
Nucleic Acids Research 46/17 2020-03-06
2018 Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni
Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05581-y
Nature Communications 9/1 2020-03-06
2018 Shweta Mendiratta, Alberto Gatto, Genevieve Almouzni
Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle
published pages: jcb.201807179, ISSN: 0021-9525, DOI: 10.1083/jcb.201807179
The Journal of Cell Biology 2020-03-06

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