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HiPhy SIGNED

High Phytosterol variants towards improved feedstocks and biofortification of crops

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HiPhy project word cloud

Explore the words cloud of the HiPhy project. It provides you a very rough idea of what is the project "HiPhy" about.

validation    membrane    nicotiana    biomolecules    molecular    isoprenoid    breeders    metabolomic    programs    mutants    regulate    folia    defect    arabidopsis    biosynthesis    bioengineering    functions    goi    suppressor    benthamiana    brassinosteroids    carry    nutrients    generation    overproduction    performed    lipids    ps    accumulation    components    faced    fact    responsible    phytosterols    steroidogenic    biologists    industries    exhibiting    comply    thaliana    waste    crops    genome    phenotype    dominant    homeostasis    cosmetic    assays    mutations    enzymes    cellular    plant    agricultural    editing    expression    material    pharmaceutical    unknown    plants    materials    genomics    alleles    implementing    precursors    elucidation    feedstock    metabolism    reinforcers    regulated    master    tobacco    acting    mutation    functional    regulators    class    valuable    characterization    extracted    variant    combined    signals    plan    mapping    concentration    semi    candidate    genes   

Project "HiPhy" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

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 Project objective

Phytosterols (PS) are valuable biomolecules used as nutrients and as feedstock material for the pharmaceutical and cosmetic industries. The challenge biologists and breeders are faced with is to develop bioengineering programs and valuable crops dedicated to the large-scale production of PS, which are currently extracted from agricultural waste materials. The goal of the proposal is to identify master regulators of PS biosynthesis and accumulation in plants. In fact, PS have essential cellular functions in plant growth and development, acting as key membrane components and membrane reinforcers, as signals in development and as precursors of brassinosteroids, a class of growth regulators. As such, the concentration of PS is highly regulated in order to comply with cellular homeostasis. To reach the goal, we will carry out a functional molecular characterization of a tobacco variant carrying a yet unknown semi-dominant mutation responsible for PS overproduction and Arabidopsis thaliana mutants exhibiting a suppressor phenotype of a defect in the production of precursors of isoprenoid lipids, such as PS. The work plan is to apply advanced genomics for next-generation mapping, leading to the elucidation of mutations in genes of interest (GOI) that regulate PS accumulation. The validation of candidate GOI will be done by genome editing and the role of novel alleles in PS metabolism will be performed by various functional and metabolomic studies. Finally, the combined expression of selected GOI with steroidogenic enzymes will be assessed by implementing in folia expression assays in Nicotiana benthamiana.

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The information about "HIPHY" are provided by the European Opendata Portal: CORDIS opendata.

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