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High Phytosterol variants towards improved feedstocks and biofortification of crops

Total Cost €


EC-Contrib. €






 HiPhy project word cloud

Explore the words cloud of the HiPhy project. It provides you a very rough idea of what is the project "HiPhy" about.

plants    precursors    defect    brassinosteroids    lipids    pharmaceutical    biologists    semi    goi    concentration    plant    regulators    genomics    homeostasis    steroidogenic    master    exhibiting    functional    molecular    faced    material    plan    editing    combined    mutants    cellular    comply    fact    mutations    cosmetic    metabolomic    responsible    implementing    components    variant    biosynthesis    reinforcers    suppressor    isoprenoid    signals    elucidation    feedstock    valuable    mapping    expression    validation    regulate    metabolism    membrane    benthamiana    overproduction    phytosterols    carry    candidate    acting    nicotiana    ps    crops    alleles    unknown    breeders    enzymes    industries    accumulation    bioengineering    waste    tobacco    genome    agricultural    genes    functions    characterization    phenotype    class    performed    folia    biomolecules    nutrients    programs    generation    regulated    extracted    dominant    assays    mutation    arabidopsis    materials    thaliana   

Project "HiPhy" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Phytosterols (PS) are valuable biomolecules used as nutrients and as feedstock material for the pharmaceutical and cosmetic industries. The challenge biologists and breeders are faced with is to develop bioengineering programs and valuable crops dedicated to the large-scale production of PS, which are currently extracted from agricultural waste materials. The goal of the proposal is to identify master regulators of PS biosynthesis and accumulation in plants. In fact, PS have essential cellular functions in plant growth and development, acting as key membrane components and membrane reinforcers, as signals in development and as precursors of brassinosteroids, a class of growth regulators. As such, the concentration of PS is highly regulated in order to comply with cellular homeostasis. To reach the goal, we will carry out a functional molecular characterization of a tobacco variant carrying a yet unknown semi-dominant mutation responsible for PS overproduction and Arabidopsis thaliana mutants exhibiting a suppressor phenotype of a defect in the production of precursors of isoprenoid lipids, such as PS. The work plan is to apply advanced genomics for next-generation mapping, leading to the elucidation of mutations in genes of interest (GOI) that regulate PS accumulation. The validation of candidate GOI will be done by genome editing and the role of novel alleles in PS metabolism will be performed by various functional and metabolomic studies. Finally, the combined expression of selected GOI with steroidogenic enzymes will be assessed by implementing in folia expression assays in Nicotiana benthamiana.

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The information about "HIPHY" are provided by the European Opendata Portal: CORDIS opendata.

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