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HiPhy SIGNED

High Phytosterol variants towards improved feedstocks and biofortification of crops

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HiPhy project word cloud

Explore the words cloud of the HiPhy project. It provides you a very rough idea of what is the project "HiPhy" about.

ps    performed    precursors    unknown    functional    genome    alleles    reinforcers    accumulation    extracted    responsible    phytosterols    tobacco    overproduction    faced    thaliana    agricultural    biosynthesis    mutation    components    validation    generation    carry    nutrients    industries    fact    plan    genomics    phenotype    expression    feedstock    biomolecules    concentration    elucidation    variant    enzymes    valuable    implementing    plant    cellular    assays    bioengineering    mutations    steroidogenic    nicotiana    acting    master    metabolism    biologists    folia    defect    homeostasis    isoprenoid    regulated    genes    exhibiting    editing    combined    characterization    suppressor    programs    class    semi    goi    lipids    dominant    crops    brassinosteroids    regulators    waste    breeders    functions    plants    molecular    signals    comply    mutants    arabidopsis    membrane    benthamiana    materials    regulate    cosmetic    candidate    metabolomic    mapping    material    pharmaceutical   

Project "HiPhy" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Phytosterols (PS) are valuable biomolecules used as nutrients and as feedstock material for the pharmaceutical and cosmetic industries. The challenge biologists and breeders are faced with is to develop bioengineering programs and valuable crops dedicated to the large-scale production of PS, which are currently extracted from agricultural waste materials. The goal of the proposal is to identify master regulators of PS biosynthesis and accumulation in plants. In fact, PS have essential cellular functions in plant growth and development, acting as key membrane components and membrane reinforcers, as signals in development and as precursors of brassinosteroids, a class of growth regulators. As such, the concentration of PS is highly regulated in order to comply with cellular homeostasis. To reach the goal, we will carry out a functional molecular characterization of a tobacco variant carrying a yet unknown semi-dominant mutation responsible for PS overproduction and Arabidopsis thaliana mutants exhibiting a suppressor phenotype of a defect in the production of precursors of isoprenoid lipids, such as PS. The work plan is to apply advanced genomics for next-generation mapping, leading to the elucidation of mutations in genes of interest (GOI) that regulate PS accumulation. The validation of candidate GOI will be done by genome editing and the role of novel alleles in PS metabolism will be performed by various functional and metabolomic studies. Finally, the combined expression of selected GOI with steroidogenic enzymes will be assessed by implementing in folia expression assays in Nicotiana benthamiana.

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The information about "HIPHY" are provided by the European Opendata Portal: CORDIS opendata.

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