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HiPhy SIGNED

High Phytosterol variants towards improved feedstocks and biofortification of crops

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HiPhy project word cloud

Explore the words cloud of the HiPhy project. It provides you a very rough idea of what is the project "HiPhy" about.

benthamiana    unknown    candidate    regulated    cosmetic    combined    isoprenoid    tobacco    accumulation    membrane    metabolomic    fact    editing    cellular    ps    dominant    plan    exhibiting    suppressor    mutants    arabidopsis    functions    implementing    components    regulate    functional    class    assays    agricultural    validation    molecular    genomics    biologists    nicotiana    material    mutation    goi    biomolecules    bioengineering    plants    semi    carry    waste    variant    performed    lipids    thaliana    expression    genes    mutations    crops    regulators    defect    overproduction    comply    acting    precursors    extracted    faced    metabolism    biosynthesis    signals    materials    master    responsible    breeders    programs    genome    elucidation    generation    brassinosteroids    industries    enzymes    pharmaceutical    plant    reinforcers    folia    steroidogenic    phytosterols    concentration    nutrients    mapping    alleles    feedstock    valuable    characterization    phenotype    homeostasis   

Project "HiPhy" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Phytosterols (PS) are valuable biomolecules used as nutrients and as feedstock material for the pharmaceutical and cosmetic industries. The challenge biologists and breeders are faced with is to develop bioengineering programs and valuable crops dedicated to the large-scale production of PS, which are currently extracted from agricultural waste materials. The goal of the proposal is to identify master regulators of PS biosynthesis and accumulation in plants. In fact, PS have essential cellular functions in plant growth and development, acting as key membrane components and membrane reinforcers, as signals in development and as precursors of brassinosteroids, a class of growth regulators. As such, the concentration of PS is highly regulated in order to comply with cellular homeostasis. To reach the goal, we will carry out a functional molecular characterization of a tobacco variant carrying a yet unknown semi-dominant mutation responsible for PS overproduction and Arabidopsis thaliana mutants exhibiting a suppressor phenotype of a defect in the production of precursors of isoprenoid lipids, such as PS. The work plan is to apply advanced genomics for next-generation mapping, leading to the elucidation of mutations in genes of interest (GOI) that regulate PS accumulation. The validation of candidate GOI will be done by genome editing and the role of novel alleles in PS metabolism will be performed by various functional and metabolomic studies. Finally, the combined expression of selected GOI with steroidogenic enzymes will be assessed by implementing in folia expression assays in Nicotiana benthamiana.

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The information about "HIPHY" are provided by the European Opendata Portal: CORDIS opendata.

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