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PDZnet SIGNED

Unraveling Principles of PDZ-mediated Cell Signaling

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PDZnet" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://pdznet.eu/
 Total cost 3˙733˙514 €
 EC max contribution 3˙733˙514 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 580˙163.00
2    NOVO NORDISK A/S DK (BAGSVAERD) participant 580˙163.00
3    UPPSALA UNIVERSITET SE (UPPSALA) participant 527˙318.00
4    SYSTASY BIOSCIENCE GMBH DE (MUNCHEN) participant 456˙204.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 307˙418.00
6    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 262˙875.00
7    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 262˙875.00
8    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) participant 258˙061.00
9    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 249˙216.00
10    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 249˙216.00

Map

 Project objective

PDZnet will create an innovative European PhD training network focusing on unraveling PDZ domain-mediated signaling networks. The emphasis will be on signaling nodes essential for the development of cancer and diseases of the nervous system, conditions that affect millions of Europeans and are major societal challenges. PDZ domains are protein and lipid recognizing modules that play a central role in trafficking and organizing diverse cell signaling assemblies, thereby allowing information to be transmitted from receptors, ion channels and transporters in the cell membrane. PDZ domain mediated interactions are emerging as conceptually novel and promising drug targets, with exciting opportunities for the development of novel therapies, especially within cancer and brain diseases. We will establish a European multidisciplinary platform integrating a plethora of complementary life science disciplines that range from chemical development of inhibitors to studies in live animals. The network encompasses 8 academic and 2 industrial beneficiaries as well as one industrial and one academic partner, which are all committed to promote frontline research, innovation and educational activities within the study of PDZ domain-mediated signal transduction pathways related to brain diseases and cancer. This interdisciplinary network will establish an outstanding training opportunity for Early Stage Researchers, who will be integrated in projects unraveling intracellular PDZ domain interactomes to provide pertinent information for discovering drug-related interactions. In a comprehensive and integrated training effort, involving a combination of scientific and transferable skills, the students will receive an interdisciplinary, intersectoral and innovative doctoral training from experienced industrial and academic leaders in well-reputed European Institutions.

 Deliverables

List of deliverables.
CDE plan Documents, reports 2020-03-20 16:08:19
PDZnet website Websites, patent fillings, videos etc. 2020-03-20 16:08:19

Take a look to the deliverables list in detail:  detailed list of PDZnet deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents
published pages: , ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00532
ACS Medicinal Chemistry Letters 2020-03-20
2016 Muna L Hilal, Maité M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-Josée Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, Hélène Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, Stéphane H R Oliet, Nathalie Sans
Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse
published pages: 5635-5651, ISSN: 1047-3211, DOI: 10.1093/cercor/bhw333
Cerebral Cortex 27/12 2020-03-20
2018 Candice Gautier, Louise Laursen, Per Jemth, Stefano Gianni
Seeking allosteric networks in PDZ domains
published pages: , ISSN: 1741-0126, DOI: 10.1093/protein/gzy033
Protein Engineering, Design and Selection 2020-03-20
2017 Eric Bailly, Alexandra Walton, Jean-Paul Borg
The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions
published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.10.030
Seminars in Cell & Developmental Biology 2020-03-20
2017 Tianliang Sun, Lida Yang, Harmandeep Kaur, Jenny Pestel, Mario Looso, Hendrik Nolte, Cornelius Krasel, Daniel Heil, Ramesh K. Krishnan, Marie-Josée Santoni, Jean-Paul Borg, Moritz Bünemann, Stefan Offermanns, Jakub M. Swiercz, Thomas Worzfeld
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
published pages: 199-215, ISSN: 0021-9525, DOI: 10.1083/jcb.201602002
The Journal of Cell Biology 216/1 2020-03-20
2018 Madeline N. Hayes, Karin McCarthy, Alexander Jin, Mariana L. Oliveira, Sowmya Iyer, Sara P. Garcia, Sivasish Sindiri, Berkley Gryder, Zainab Motala, G. Petur Nielsen, Jean-Paul Borg, Matt van de Rijn, David Malkin, Javed Khan, Myron S. Ignatius, David M. Langenau
Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma
published pages: 414-427.e6, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.02.002
Cell Stem Cell 22/3 2020-03-20
2018 Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M. Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I. Weis, Jean-Laurent Casanova, Anne Puel, Kathl
Epithelial barrier dysfunction in desmoglein-1 deficiency
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.04.007
Journal of Allergy and Clinical Immunology 2020-03-20
2017 Amandine Cartier-Michaud, Anne-Laure Bailly, Stéphane Betzi, Xiaoli Shi, Jean-Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean-Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand-Lions
Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis
published pages: e1006803, ISSN: 1549-1277, DOI: 10.1371/journal.pgen.1006803
PLOS Genetics 13/6 2020-03-20
2017 Candice Gautier, Lorenzo Visconti, Per Jemth, Stefano Gianni
Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12827-0
Scientific Reports 7/1 2020-03-20
2018 Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg, Sudhansu. K. Dey
Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03092-4
Nature Communications 9/1 2020-03-20
2017 Avais M. Daulat, Jean-Paul Borg
Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment
published pages: 113-125, ISSN: 2405-8033, DOI: 10.1016/j.trecan.2017.01.001
Trends in Cancer 3/2 2020-03-20
2018 Concetta Saponaro, Sara Sergio, Antonio Coluccia, Maria De Luca, Giuseppe La Regina, Luca Mologni, Valeria Famiglini, Valentina Naccarato, Daniela Bonetti, Candice Gautier, Stefano Gianni, Daniele Vergara, Michel Salzet, Isabelle Fournier, Cecilia Bucci, Romano Silvestri, Carlo Gambacorti Passerini, Michele Maffia, Addolorata Maria Luce Coluccia
β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy
published pages: 3301-3316, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0170-y
Oncogene 37/24 2020-03-20
2019 Antonio Coluccia, Giuseppe La Regina, Valentina Naccarato, Marianna Nalli, Viviana Orlando, Stefano Biagioni, Maria Laura De Angelis, Marta Baiocchi, Candice Gautier, Stefano Gianni, Fiorella Di Pastena, Laura Di Magno, Gianluca Canettieri, Addolorata Maria Luce Coluccia, Romano Silvestri
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents
published pages: , ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.8b00532
ACS Medicinal Chemistry Letters 2020-03-20

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The information about "PDZNET" are provided by the European Opendata Portal: CORDIS opendata.

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