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B-response SIGNED

Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans

Total Cost €

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EC-Contrib. €

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Partnership

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Project "B-response" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙098˙750 €
 EC max contribution 2˙098˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙098˙750.00

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 Project objective

B cells are the main actors of successful vaccines, and their protective capacity relies on several subsets with innate-like and memory properties that fulfill different effector functions. In the present project, we wish to develop approaches in both mice and humans, to confront the similarities and the differences of their B cell responses.

The three aims proposed are: 1) To study the different B cell subsets and TFH cells engaged in a memory response through the use of a new mouse reporter line allowing their irreversible labeling (inducible Cre recombinase under the control of the Bcl6 gene): this will be performed in different conditions of TH1 vs. TH2 polarization, as well as during a chronic viral infection, in which virus-specific antibodies have been shown to be required to control the disease (in collaboration with D. Pinschewer, Basel) 2) To study whether the lifelong persistence of B cell memory, as occurs for memory B cells against smallpox that we can obtain at high purity from aged donor's spleens, corresponds to a specific transcriptional program at the miRNA, lncRNA or mRNA level, as well as a specific cell homeostasis 3) To discriminate the specific effector function of human marginal zone and IgM memory B cells in, respectively, T-independent and T-dependent responses, as well as their specific differentiation/diversification pathway.

The general goal is to delineate the regulatory pathways leading to the activation and persistence of the different B cell subsets, allowing for a better understanding of the conditions leading to their pathological or beneficial mobilization.

 Publications

year authors and title journal last update
List of publications.
2020 Jean-Claude Weill, Claude-Agnès Reynaud
IgM memory B cells: specific effectors of innate-like and adaptive responses
published pages: 1-6, ISSN: 0952-7915, DOI: 10.1016/j.coi.2019.09.003
Current Opinion in Immunology 63 2020-02-06
2020 Fallet, B., Hao, Y., Florova, M., Cornille, K., Verge de los Aires, A., Girelli Zubani, G., Ertuna, Y., Greiff, V., Menzel, U., Hammad, K., Merkler, D., Reddy, S., Weill, J.-C., Reynaud, C.-A. and Pinschewer, D
Chronic viral infection promotes efficient germinal center B cell responses
published pages: 1013–1026, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.12.023
Cell Reports vol. 30, January 28th, 2020 2020-02-06

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