Opendata, web and dolomites

VERDI SIGNED

polyValent mEsopoRous nanosystem for bone DIseases

Total Cost €

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EC-Contrib. €

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Project "VERDI" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.ucm.es/valletregigroup/erc
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 2˙500˙000.00

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 Project objective

Finding simple solutions to complex problems has been a challenge for humankind for decades. VERDI aims at designing a multifunctional nanosystem to heal complex bone diseases. This is an engineering challenge that will be tackled through the use of building blocks designed on the basis of cutting-edge technology. These building blocks will be assembled into a versatile multifunctional nanosystem that can be adapted through slight variations for the treatment of three diseases of clinical relevance: bone infection, bone cancer and osteoporosis. The novelty of this proposal is the design of a nanosystem that may address several diseases using a unique, versatile and scalable strategy. Mesoporous silica nanoparticles are selected as the main component of the nanoplatform because of their biocompatibility, robustness, loading capacity and versatile surface modification. The nanosystem will be modified by rational selection of building blocks, with targeting and/or therapeutic abilities, to tackle either one or a combination of pathologies. These features will enable us to deliver a library of nanomedicines using a toolbox of building blocks, customizing a specific nanosystem depending on the disease to be treated. The risks associated to VERDI are numerous, such as the great complexity of producing completely asymmetrical nanoparticles (NPs), the risk that modifying a drug or therapeutic peptide will affect its therapeutic efficacy, and the difficulty of achieving effective in vivo bone targeted NPs. A contingency plan for each risk has been elaborated. The expertise and capacities of my research group guarantees successful results, which we expect to lead to a revolution in the therapy of bone cancer, bone infection and osteoporosis. Additionally, the application of a single technology for the treatment of three different but frequently associated diseases will favour industrial scale-up process, thereby promoting the transition of nanomedicine from bench to bedside.

 Publications

year authors and title journal last update
List of publications.
2020 Juan L. Paris, Gonzalo Villaverde, Sergio Gómez-Graña, María Vallet-Regí
Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy
published pages: 459-468, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.11.004
Acta Biomaterialia 101 2020-03-13
2020 L. Casarrubios, N. Gómez-Cerezo, S. Sánchez-Salcedo, M.J. Feito, M.C. Serrano, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep
published pages: 544-553, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.10.033
Acta Biomaterialia 101 2020-03-13
2020 Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis
published pages: 83, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics12010083
Pharmaceutics 12/1 2020-03-13
2020 Juan L. Paris, María Vallet-Regí
Ultrasound-Activated Nanomaterials for Therapeutics
published pages: 220-229, ISSN: 0009-2673, DOI: 10.1246/bcsj.20190346
Bulletin of the Chemical Society of Japan 93/2 2020-03-13
2020 Daniel Arcos, María Vallet-Regí
Substituted hydroxyapatite coatings of bone implants
published pages: 1781-1800, ISSN: 2050-7518, DOI: 10.1039/c9tb02710f
Journal of Materials Chemistry B 8/9 2020-03-13
2020 M. Natividad Gómez-Cerezo, Daniel Lozano, Daniel Arcos, María Vallet-Regí, Cedryck Vaquette
The effect of biomimetic mineralization of 3D-printed mesoporous bioglass scaffolds on physical properties and in vitro osteogenicity
published pages: 110572, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110572
Materials Science and Engineering: C 109 2020-03-13
2020 Carlotta Pontremoli, Isabel Izquierdo-Barba, Giorgia Montalbano, María Vallet-Regí, Chiara Vitale-Brovarone, Sonia Fiorilli
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration
published pages: 92-103, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2019.12.047
Journal of Colloid and Interface Science 563 2020-03-13
2019 María Vallet-Regí, Blanca González, Isabel Izquierdo-Barba
Nanomaterials as Promising Alternative in the Infection Treatment
published pages: 3806, ISSN: 1422-0067, DOI: 10.3390/ijms20153806
International Journal of Molecular Sciences 20/15 2019-10-17
2019 Miguel Manzano, María Vallet Regí
Mesoporous Silica Nanoparticles for Drug Delivery.
published pages: 1902634, ISSN: 1616-301X, DOI: 10.1002/adfm.201902634
Advanced Functional Materials 2019-10-17
2019 Juan L. Paris, Alejandro Baeza, María Vallet-Regí
Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics
published pages: 1095-1112, ISSN: 1742-5247, DOI: 10.1080/17425247.2019.1662786
Expert Opinion on Drug Delivery 16/10 2019-10-17
2019 Rafael Alvarez , Sandra Muñoz-Piña, María U. González, Isabel Izquierdo-Barba, Iván Fernández-Martínez, Victor Rico, Daniel Arcos, Aurelio García-Valenzuela, Alberto Palmero, María Vallet-Regi, Agustín R. , González-Elipe, José M. García-Martín
Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors.
published pages: 1217, ISSN: 2079-4991, DOI: 10.3390/nano9091217
Nanomaterials 2019-10-17
2019 E. Varini, S. Sánchez-Salcedo, G. Malavasi, G. Lusvardi, M. Vallet-Regí, A.J. Salinas
Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: Bioactivity, biocompatibility and reactive oxygen species activity
published pages: 109971, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.109971
Materials Science and Engineering: C 105 2019-09-09
2019 Patricia Mora-Raimundo, Daniel Lozano, Miguel Manzano, María Vallet-Regí
Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment
published pages: 5451-5464, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b00241
ACS Nano 13/5 2019-08-30
2019 Giulia Rossella Delpiano, Maria F. Casula, Marco Piludu, Riccardo Corpino, Pier Carlo Ricci, María Vallet-Regí, Enrico Sanjust, Maura Monduzzi, Andrea Salis
Assembly of Multicomponent Nano-Bioconjugates Composed of Mesoporous Silica Nanoparticles, Proteins, and Gold Nanoparticles
published pages: 11044-11052, ISSN: 2470-1343, DOI: 10.1021/acsomega.9b01240
ACS Omega 4/6 2019-08-30
2019 N. Gómez-Cerezo, L. Casarrubios, M. Saiz-Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí
Mesoporous bioactive glass/É›-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep
published pages: 393-402, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.04.019
Acta Biomaterialia 90 2019-08-30
2019 Marina Martínez-Carmona, Isabel Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Concanavalin A-targeted mesoporous silica nanoparticles for infection treatment
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.07.001
Acta Biomaterialia 2019-08-30
2019 Nadia Garino, Pasquale Sanvitale, Bianca Dumontel, Marco Laurenti, Montserrat Colilla, Isabel Izquierdo-Barba, Valentina Cauda, Maria Vallet-Regì
Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent
published pages: 11312-11321, ISSN: 2046-2069, DOI: 10.1039/c8ra10236h
RSC Advances 9/20 2019-08-30
2017 M. Gisbert-Garzaran, D. Lozano, M. Vallet-Regí, M. Manzano
Self-immolative polymers as novel pH-responsive gate keepers for drug delivery
published pages: 132-136, ISSN: 2046-2069, DOI: 10.1039/c6ra26771h
RSC Advances 7/1 2019-07-25
2018 Alejandro Baeza, María Vallet-Regí
Nanomotors for Nucleic Acid, Proteins, Pollutants and Cells Detection
published pages: 1579, ISSN: 1422-0067, DOI: 10.3390/ijms19061579
International Journal of Molecular Sciences 19/6 2019-07-25
2018 Sandra Sanchez-Salcedo, Maria Vallet-Regí, Sophia Allaf Shahin, Carlotta A. Glackin, Jeffrey I. Zink
Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy
published pages: 114-124, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.116
Chemical Engineering Journal 340 2019-07-25
2017 Marta Maycas, María Teresa Portolés, María Concepción Matesanz, Irene Buendía, Javier Linares, María José Feito, Daniel Arcos, María Vallet-Regí, Lilian I. Plotkin, Pedro Esbrit, Arancha R. Gortázar
High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation
published pages: 3611-3621, ISSN: 0021-9541, DOI: 10.1002/jcp.25829
Journal of Cellular Physiology 232/12 2019-07-25
2018 Mónica Cicuéndez, Joana Flores, Helena Oliveira, M. Teresa Portolés, María Vallet-Regí, Mercedes Vila, Iola F. Duarte
Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia
published pages: 340-348, ISSN: 0928-4931, DOI: 10.1016/j.msec.2018.05.057
Materials Science and Engineering: C 91 2019-07-25
2018 Mónica Cicuéndez, Juan C. Doadrio, Ana Hernández, M. Teresa Portolés, Isabel Izquierdo-Barba, María Vallet-Regí
Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection
published pages: 450-461, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.11.009
Acta Biomaterialia 65 2019-07-25
2017 A. Baeza, R. R. Castillo, A. Torres-Pardo, J. M. González-Calbet, M. Vallet-Regí
Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: what does it reveal?
published pages: 2714-2725, ISSN: 2050-7518, DOI: 10.1039/c6tb03062a
Journal of Materials Chemistry B 5/15 2019-07-25
2018 Rafael R. Castillo, David Henrández-Escobar, Sergio Gómez-Graña, Maria Vallet-Regi
Reversible nanogate system for Mesoporous Silica Nanoparticles based on Diels-Alder adducts.
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201706100
Chemistry - A European Journal 2019-07-25
2017 Rafael R. Castillo, Alejandro Baeza, María Vallet-Regí
Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors
published pages: 353-377, ISSN: 2047-4830, DOI: 10.1039/c6bm00872k
Biomaterials Science 5/3 2019-07-25
2018 Eduardo Guisasola, Laura Asín, Lilianne Beola, Jesús M. de la Fuente, Alejandro Baeza, María Vallet-Regí
Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers
published pages: , ISSN: 1944-8244, DOI: 10.1021/acsami.8b02398
ACS Applied Materials & Interfaces 2019-07-25
2017 María Rocío Villegas, Alejandro Baeza, Achraf Noureddine, Paul N. Durfee, Kimberly S. Butler, Jacob Ongudi Agola, C. Jeffrey Brinker, María Vallet-Regí
Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices
published pages: 112-120, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.7b03128
Chemistry of Materials 30/1 2019-07-25
2017 M. Martínez-Carmona, D. Lozano, A. Baeza, M. Colilla, M. Vallet-Regí
A novel visible light responsive nanosystem for cancer treatment
published pages: 15967-15973, ISSN: 2040-3364, DOI: 10.1039/c7nr05050j
Nanoscale 9/41 2019-07-25
2017 Juan L. Paris, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano, María Vallet-Regí
Tuning mesoporous silica dissolution in physiological environments: a review
published pages: 8761-8771, ISSN: 0022-2461, DOI: 10.1007/s10853-017-0787-1
Journal of Materials Science 52/15 2019-07-25
2018 Juan L. Paris, Miguel Manzano, M. Victoria Cabañas, María Vallet-Regí
Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells
published pages: , ISSN: 2040-3364, DOI: 10.1039/C8NR00693H
Nanoscale 2019-07-25
2018 Miguel Manzano, María Vallet-Regí
Mesoporous silica nanoparticles in nanomedicine applications
published pages: 65, ISSN: 0957-4530, DOI: 10.1007/s10856-018-6069-x
Journal of Materials Science: Materials in Medicine 29/5 2019-07-25
2018 M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí
Self-immolative chemistry in nanomedicine
published pages: 24-31, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.098
Chemical Engineering Journal 340 2019-07-25
2016 Rafael R. Castillo, Montserrat Colilla, María Vallet-Regí
Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer
published pages: 229-243, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1211637
Expert Opinion on Drug Delivery 14/2 2019-07-25
2018 Sandra Sanchez-Salcedo, Gianluca Malavasi, Antonio Salinas, Gigliola Lusvardi, Luca Rigamonti, Ledi Menabue, Maria Vallet-Regi
Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
published pages: 367, ISSN: 1996-1944, DOI: 10.3390/ma11030367
Materials 11/3 2019-07-25
2018 Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, María Vallet-Regí, Antonio Salinas
Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin
published pages: 592, ISSN: 2079-4991, DOI: 10.3390/nano8080592
Nanomaterials 8/8 2019-07-25
2018 Juan L. Paris, Christophoros Mannaris, M. Victoria Cabañas, Robert Carlisle, Miguel Manzano, María Vallet-Regí, Constantin C. Coussios
Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery
published pages: 2-8, ISSN: 1385-8947, DOI: 10.1016/j.cej.2017.12.051
Chemical Engineering Journal 340 2019-07-25
2017 Victoria López, Maria Rocío Villegas, Verónica Rodríguez, Gonzalo Villaverde, Daniel Lozano, Alejandro Baeza, María Vallet-Regí
Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria
published pages: 26697-26706, ISSN: 1944-8244, DOI: 10.1021/acsami.7b06906
ACS Applied Materials & Interfaces 9/32 2019-07-25
2017 Alejandro Baeza, Daniel Ruiz-Molina, María Vallet-Regí
Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks
published pages: 783-796, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1229298
Expert Opinion on Drug Delivery 14/6 2019-07-25
2018 Blanca González, Montserrat Colilla, Jaime Díez, Daniel Pedraza, Marta Guembe, Isabel Izquierdo-Barba, María Vallet-Regí
Mesoporous silica nanoparticles decorated with polycationic dendrimers for infection treatment
published pages: 261-271, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.12.041
Acta Biomaterialia 68 2019-07-25
2017 MIGUEL MANZANO GARCIA, Khalid S. Mohammad, Theresa A. Guise, Maria Vallet-Regi
Mechanisms of Muscle Weakness Associated with Bone Metastases
published pages: 1-5, ISSN: 2377-0902, DOI: 10.15436/2377-0902.17.1188
International Journal of Cancer and Oncology 4/2 2019-07-25
2018 N. Gómez-Cerezo, L. Casarrubios, I. Morales, M.J. Feito, M. Vallet-Regí, D. Arcos, M.T. Portolés
Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages
published pages: 309-320, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.05.099
Journal of Colloid and Interface Science 528 2019-07-25
2018 M. Rocío Villegas, Alejandro Baeza, Alicia Usategui, Pablo L Ortiz-Romero, José L. Pablos, María Vallet-Regí
Collagenase nanocapsules: An approach to fibrosis treatment
published pages: 430-438, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.05.007
Acta Biomaterialia 74 2019-07-25
2018 Eduardo Guisasola, Alejandro Baeza, Laura Asín, Jesús M. de la Fuente, María Vallet-Regí
Heating at the Nanoscale through Drug-Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles
published pages: 1800007, ISSN: 2366-9608, DOI: 10.1002/smtd.201800007
Small Methods 2019-07-25
2017 Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Montserrat Grau, Ana I. Flores, María Vallet-Regí
Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy
published pages: 5528-5537, ISSN: 2040-3364, DOI: 10.1039/c7nr01070b
Nanoscale 9/17 2019-07-25
2018 Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization
published pages: , ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2018.02.019
Colloids and Surfaces B: Biointerfaces 2019-07-25
2018 María Vallet-Regí, Montserrat Colilla, Isabel Izquierdo-Barba, Miguel Manzano
Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights
published pages: 47, ISSN: 1420-3049, DOI: 10.3390/molecules23010047
Molecules 23/1 2019-07-25
2017 Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, María Vallet-Regí
Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment
published pages: 7174-7179, ISSN: 0947-6539, DOI: 10.1002/chem.201605947
Chemistry - A European Journal 23/30 2019-07-25
2017 Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí
pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
published pages: 3, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010003
Bioengineering 4/4 2019-07-25
2018 Valentina Nairi, Sara Medda, Marco Piludu, Maria Francesca Casula, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers
published pages: 42-50, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.011
Chemical Engineering Journal 340 2019-07-25
2017 Lorena Polo, Natividad Gómez-Cerezo, Elena Aznar, José-Luis Vivancos, Félix Sancenón, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
published pages: 114-126, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.12.025
Acta Biomaterialia 50 2019-07-25
2017 M. Vallet-Regí, P. Mora-Raimundo, M. Manzano
Nanoparticles for the treatment of osteoporosis
published pages: 259-274, ISSN: 2375-1495, DOI: 10.3934/bioeng.2017.2.259
AIMS Bioengineering 4/2 2019-07-25
2017 Renny Mathew, Claudia Turdean-Ionescu, Yang Yu, Baltzar Stevensson, Isabel Izquierdo-Barba, Ana García, Daniel Arcos, María Vallet-Regí, Mattias Edén
Proton Environments in Biomimetic Calcium Phosphates Formed from Mesoporous Bioactive CaO–SiO 2 –P 2 O 5 Glasses in Vitro : Insights from Solid-State NMR
published pages: 13223-13238, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.7b03469
The Journal of Physical Chemistry C 121/24 2019-07-25
2017 Sandra Sánchez-Salcedo, Ana García, María Vallet-Regí
Prevention of bacterial adhesion to zwitterionic biocompatible mesoporous glasses
published pages: 472-486, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.05.005
Acta Biomaterialia 57 2019-07-25
2017 Anahí Philippart, Natividad Gómez-Cerezo, Daniel Arcos, Antonio J. Salinas, Elena Boccardi, Maria Vallet-Regi, Aldo R. Boccaccini
Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide
published pages: 90-97, ISSN: 0022-3093, DOI: 10.1016/j.jnoncrysol.2016.10.031
Journal of Non-Crystalline Solids 455 2019-07-25
2018 Antonio J. Salinas, José M. Blanco-Bécares, Okan Mersinlioglu, Laura Casarrubios, Daniel Fernández-Villa, María J. Feito, Teresa Portolés, Blanca González, María Vallet-Regí
Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating
published pages: 6880-6891, ISSN: 2365-6549, DOI: 10.1002/slct.201703130
ChemistrySelect 3/24 2019-07-25
2018 María Rocío Villegas, Alejandro Baeza, María Vallet-Regí
Nanotechnological Strategies for Protein Delivery
published pages: 1008, ISSN: 1420-3049, DOI: 10.3390/molecules23051008
Molecules 23/5 2019-07-25
2017 María Vallet‐Regí, Miguel Manzano, Leocadio Rodriguez‐Mañas, Marta Checa López, Matti Aapro, Lodovico Balducci
Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions
published pages: 335-342, ISSN: 1083-7159, DOI: 10.1634/theoncologist.2016-0276
The Oncologist 22/3 2019-07-25
2018 María Vallet-Regi, Antonio Salinas
Role of the Short Distance Order in Glass Reactivity
published pages: 415, ISSN: 1996-1944, DOI: 10.3390/ma11030415
Materials 11/3 2019-07-25
2017 María Villegas, Lorena Garcia-Uriostegui, Ofelia Rodríguez, Isabel Izquierdo-Barba, Antonio Salinas, Guillermo Toriz, María Vallet-Regí, Ezequiel Delgado
Lysine-Grafted MCM-41 Silica as an Antibacterial Biomaterial
published pages: 80, ISSN: 2306-5354, DOI: 10.3390/bioengineering4040080
Bioengineering 4/4 2019-07-25
2017 Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone
Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration
published pages: 493-504, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012
Acta Biomaterialia 55 2019-07-25
2018 Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
ZnO Nanostructures for Drug Delivery and Theranostic Applications
published pages: 268, ISSN: 2079-4991, DOI: 10.3390/nano8040268
Nanomaterials 8/4 2019-07-25
2018 N. Gómez-Cerezo, E. Verron, V. Montouillout, F. Fayon, P. Lagadec, J.M. Bouler, B. Bujoli, D. Arcos, M. Vallet-Regí
The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.06.036
Acta Biomaterialia 2019-07-25
2018 Gonzalo Villaverde, Sergio Gómez-Graña, Eduardo Guisasola, Isabel García, Christoph Hanske, Luis M. Liz-Marzán, Alejandro Baeza, Maria Vallet-Regí
Targeted Chemo-Photothermal Therapy: A Nanomedicine Approximation to Selective Melanoma Treatment
published pages: 1800148, ISSN: 0934-0866, DOI: 10.1002/ppsc.201800148
Particle & Particle Systems Characterization 2019-07-25
2017 Rafaela García-Alvarez, Isabel Izquierdo-Barba, María Vallet-Regí
3D scaffold with effective multidrug sequential release against bacteria biofilm
published pages: 113-126, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.11.028
Acta Biomaterialia 49 2019-07-25
2018 Daniel Pedraza, Jaime Díez, Isabel-Izquierdo-Barba, Montserrat Colilla, María Vallet-Regí
Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment
published pages: 1-12, ISSN: 2299-3932, DOI: 10.1515/bglass-2018-0001
Biomedical Glasses 4/1 2019-07-25
2018 Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment
published pages: 393-404, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.11.007
Acta Biomaterialia 65 2019-07-25
2018 Natalio García-Honduvilla, Alejandro Coca, Miguel A Ortega, Cynthia Trejo, Jesús Román, Juan Peña, M Victoria Cabañas, Maria Vallet Regi, Julia Buján
Improved connective integration of a degradable 3D-nano-apatite/agarose scaffold subcutaneously implanted in a rat model
published pages: 741-752, ISSN: 0885-3282, DOI: 10.1177/0885328218810084
Journal of Biomaterials Applications 33/5 2019-07-25
2019 Juan L. Paris, Paz de la Torre, M. Victoria Cabañas, Miguel Manzano, Ana I. Flores, María Vallet-Regí
Suicide-gene transfection of tumor-tropic placental stem cells employing ultrasound-responsive nanoparticles
published pages: 372-378, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.006
Acta Biomaterialia 83 2019-07-25
2018 Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
The Role of Zwitterionic Materials in the Fight against Proteins and Bacteria
published pages: 125, ISSN: 2305-6320, DOI: 10.3390/medicines5040125
Medicines 5/4 2019-07-25
2018 Laura Casarrubios, Natividad Gómez-Cerezo, María José Feito, María Vallet-Regí, Daniel Arcos, María Teresa Portolés
Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures
published pages: 258-268, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.10.019
European Journal of Pharmaceutics and Biopharmaceutics 133 2019-07-25
2019 Noemí Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties
published pages: 317-327, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.012
Acta Biomaterialia 84 2019-07-25
2018 Rafael R. Castillo, Daniel Lozano, María Vallet-Regí
Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery
published pages: 3677-3685, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00603
Bioconjugate Chemistry 29/11 2019-07-25
2018 Marina Martínez-Carmona, Yurii Gun’ko, María Vallet-Regí
Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection
published pages: 279, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10040279
Pharmaceutics 10/4 2019-07-25
2019 I. Izquierdo-Barba, L. Santos-Ruiz, J. Becerra, M.J. Feito, D. Fernández-Villa, M.C. Serrano, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, D. Monopoli, H. Afonso, M.T. Portolés, D. Arcos, M. Vallet-Regí
Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment
published pages: 456-466, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.017
Acta Biomaterialia 83 2019-07-25
2019 Rafael R. Castillo, Daniel Lozano, Blanca González, Miguel Manzano, Isabel Izquierdo-Barba, María Vallet-Regí
Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update
published pages: 1-25, ISSN: 1742-5247, DOI: 10.1080/17425247.2019.1598375
Expert Opinion on Drug Delivery 2019-07-25
2019 María Vallet-Regí
Bioceramics: from bone substitutes to nanoparticles for drug delivery
published pages: , ISSN: 0033-4545, DOI: 10.1515/pac-2018-0505
Pure and Applied Chemistry 0/0 2019-07-25
2019 Miguel Manzano, María Vallet-Regí
Ultrasound responsive mesoporous silica nanoparticles for biomedical applications
published pages: 2731-2740, ISSN: 1359-7345, DOI: 10.1039/c8cc09389j
Chemical Communications 55/19 2019-07-25
2019 Juan L. Paris, Nuria Lafuente-Gómez, M. Victoria Cabañas, Jesús Román, Juan Peña, María Vallet-Regí
Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties
published pages: 441-449, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.01.013
Acta Biomaterialia 86 2019-07-25
2019 Sandra Montalvo-Quiros, Guillermo Aragoneses-Cazorla, Laura Garcia-Alcalde, María Vallet-Regí, Blanca González, Jose L. Luque-Garcia
Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics
published pages: 4531-4545, ISSN: 2040-3364, DOI: 10.1039/c8nr07667g
Nanoscale 11/10 2019-07-25
2019 Rafael R. Castillo, María Vallet-Regí
Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety.
published pages: 929, ISSN: 1422-0067, DOI: 10.3390/ijms20040929
International Journal of Molecular Sciences 20/4 2019-07-25
2018 M.V. Cabañas, D. Lozano, A. Torres-Pardo, C. Sobrino, J. González-Calbet, D. Arcos, M. Vallet-Regí
Features of aminopropyl modified mesoporous silica nanoparticles. Implications on the active targeting capability
published pages: 260-269, ISSN: 0254-0584, DOI: 10.1016/j.matchemphys.2018.09.005
Materials Chemistry and Physics 220 2019-07-25
2018 Lorena Polo, Natividad Gómez-Cerezo, Alba García-Fernández, Elena Aznar, Jose Luis Vivancos, Daniel Arcos, María Vallet-Regí, Ramón Martínez-Máñez
Mesoporous bioactive glasses equipped with stimuli-responsive molecular gates for the controlled delivery of levofloxacin against bacteria
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201803301
Chemistry - A European Journal 2019-07-25
2018 Rebeca Pérez, Sandra Sanchez-Salcedo, Daniel Lozano, Clara Heras, Pedro Esbrit, María Vallet-Regí, Antonio Salinas
Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin
published pages: 592, ISSN: 2079-4991, DOI: 10.3390/nano8080592
Nanomaterials 8/8 2019-07-25
2018 Preethi Balasubramanian, Antonio J. Salinas, Sandra Sanchez-Salcedo, Rainer Detsch, Maria Vallet-Regi, Aldo R. Boccaccini
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO
published pages: 217-224, ISSN: 0022-3093, DOI: 10.1016/j.jnoncrysol.2018.07.073
Journal of Non-Crystalline Solids 500 2019-07-25
2019 Gonzalo Villaverde, Arantzazu Alfranca, África Gonzalez-Murillo, Gustavo J. Melen, Rafael R. Castillo, Manuel Ramírez, Alejandro Baeza, María Vallet-Regí
Molecular Scaffolds as Double-Targeting Agents For the Diagnosis and Treatment of Neuroblastoma
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201811691
Angewandte Chemie International Edition 2019-07-25
2019 Noemí Encinas, Mercedes Angulo, Carlos Astorga, Montserrat Colilla, Isabel Izquierdo-Barba, María Vallet-Regí
Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties
published pages: 317-327, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.12.012
Acta Biomaterialia 84 2019-07-25

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The information about "VERDI" are provided by the European Opendata Portal: CORDIS opendata.

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