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BSSTD SIGNED

Bioelectrochemical Sensing of Sexually Transmitted Diseases

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EC-Contrib. €

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Partnership

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Project "BSSTD" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-09-15   to  2018-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

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 Project objective

The detection of sexually transmitted diseases (STDs) has become a serious medical concern around the globe, as the number of reported cases increases every year, particularly in the United Kingdom. Infection with STDs, such as Gonorrhea and Chlamydia can result in long term health issues, such as infertility, reproductive tract cancer, and poor perinatal outcome. The successful treatment of these diseases depends on a quick and reliable method of diagnosis, which will be the topic of this proposal. The overall goal of the proposed research is to develop a detection method for bacteria, associated with STDs, based on bioelectrochemical techniques. Specific objectives of the proposed research consist of the identification of a redox couple functioning as electron donor for bacterial oxidases, the specific binding of bacteria to a macroelectrode, the electrochemical recognition of immobilized bacteria at the macroelectrode, testing for false-positive and false-negative results, the varying of target cultures to extend the scope of the proposed research, and finally, the assembly of a biosensing device using disposable screen printed electrodes. The proposed technique will make use of a biochemical test for aerobic bacteria, the oxidase test, by adapting it for electrochemical detection. In doing so, high selectivity will be achieved by targeted binding of living bacteria to immobilized antibodies on an electrode, whereas sensitivity will be strongly increased through the localized electrochemical detection of the oxidase test product. To demonstrate the usefulness and applicability to medical diagnostics, an approach is proposed to transfer the presented proof of concept to portable screen printed electrodes, which will permit the routine use of this concept in a bioelectrochemical handheld device. The proposed research answers the European Commission’s call for the development of new technologies in the health sector and an urgent need in public health monitoring.

 Publications

year authors and title journal last update
List of publications.
2019 Sabine Kuss, Rosa A. S. Couto, Rhiannon M. Evans, Hayley Lavender, Christoph C. Tang, Richard G. Compton
Versatile Electrochemical Sensing Platform for Bacteria
published pages: 4317-4322, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00326
Analytical Chemistry 91/7 2020-04-01
2017 Sabine Kuss, Richard G. Compton
Electrocatalytic detection of ascorbic acid using N,N,N’,N’-tetramethyl-para-phenylene-diamine (TMPD) mediated oxidation at unmodified gold electrodes; reaction mechanism and analytical application
published pages: , ISSN: 0013-4686, DOI: 10.1016/j.electacta.2017.05.003
Electrochimica Acta 2019-06-13
2018 Alex Lukmanto Suherman, Giorgia Zampardi, Sabine Kuss, Eden Elizabeth Louise Tanner, Hatem M.A. Amin, Neil P Young, Richard G Compton
Understanding Gold Nanoparticle Dissolution in Cyanide-Containing Solution via Impact-Chemistry
published pages: , ISSN: 1463-9076, DOI: 10.1039/C8CP05154B
Physical Chemistry Chemical Physics 2019-05-08
2018 Rosa A. S. Couto, Lifu Chen, Sabine Kuss, Richard G. Compton
Detection of Escherichia coli bacteria by impact electrochemistry
published pages: , ISSN: 0003-2654, DOI: 10.1039/C8AN01675E
The Analyst 2019-04-02
2018 Sabine Kuss, Hatem M. A. Amin, Richard G. Compton
Electrochemical Detection of Pathogenic Bacteria-Recent Strategies, Advances and Challenges
published pages: , ISSN: 1861-4728, DOI: 10.1002/asia.201800798
Chemistry - An Asian Journal 2019-04-02
2018 Alex L. Suherman, Sabine Kuss, Eden E. L. Tanner, Neil P. Young, Richard G. Compton
Electrochemical Hg 2+ detection at tannic acid-gold nanoparticle modified electrodes by square wave voltammetry
published pages: 2035-2041, ISSN: 0003-2654, DOI: 10.1039/C8AN00508G
The Analyst 143/9 2019-04-03
2017 S. Kuss, E. E. L. Tanner, M. Ordovas-Montanes, R. G. Compton
Electrochemical recognition and quantification of cytochrome c expression in Bacillus subtilis and aerobe/anaerobe Escherichia coli using N,N,N′,N′-tetramethyl-para-phenylene-diamine (TMPD)
published pages: 7682-7688, ISSN: 2041-6520, DOI: 10.1039/C7SC03498A
Chem. Sci. 8/11 2019-04-03

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