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Neurofibres SIGNED

Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury

Total Cost €

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EC-Contrib. €

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Partnership

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 Neurofibres project word cloud

Explore the words cloud of the Neurofibres project. It provides you a very rough idea of what is the project "Neurofibres" about.

ensuing    assembling    investigation    fibrosis    neural    regeneration    circuit    electrostimulation    perform    mf    electroconducting    engineered    microsystems    probe    bio    central    affibodies    immunological    specialised    complementary    meet    insult    implantation    damaged    physics    rodent    chemical    efforts    neuronal    hold    company    specialists    electro    recording    join    spinal    electronic    interdisciplinary    scaffolds    glial    cell    conductivity    mechanical    add    device    functionalisation    rodents    biomaterials    breakthrough    models    stability    migration    safe    electronics    implanted    microfibre    cord    dual    swine    repairing    implantable    electrical    mfs    motor    sensory    cns    neuroregenerative    sci    compromise    tissue    stimulation    promise    biologically    interconnection    function    neuroscientists    medical    ultrasensitive    inflicts    miniaturisation    axonal    responsive    activation    biofunctionalisation    microcables    guided    microconnectors    electroactive    engineering    nervous    negligible    serve    neurofibres    protein    additional    treatment    fabrication    strength    inflammation    injury    connective    microfibres   

Project "Neurofibres" data sheet

The following table provides information about the project.

Coordinator
SERVICIO DE SALUD DE CASTILLA LA MANCHA 

Organization address
address: AVENIDA RIO GUADIANA 4
city: TOLEDO
postcode: 45007
website: http://sescam.jccm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.neurofibres.eu
 Total cost 5˙888˙491 €
 EC max contribution 5˙094˙120 € (87%)
 Programme 1. H2020-EU.1.2.2. (FET Proactive)
 Code Call FETPROACT-2016
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SERVICIO DE SALUD DE CASTILLA LA MANCHA ES (TOLEDO) coordinator 751˙835.00
2    AXON CABLE FR (MONTMIRAIL) participant 910˙000.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 708˙090.00
4    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 692˙500.00
5    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 681˙875.00
6    UNIVERSITAT DES SAARLANDES DE (SAARBRUCKEN) participant 680˙000.00
7    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 669˙820.00

Map

 Project objective

Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in “Neuroregenerative Bio-electronics”, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives: 1) To improve the electrical conductivity, strength, and chemical stability of the microfibres. 2) To develop electro-responsive engineered affibodies for microfibre functionalisation. 3) To develop the technology for MF interconnection and assembling into implantable systems. 4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue responses to the implanted MFs and applied electrostimulation in rodent and swine SCI models. 5) To investigate the motor and sensory effects of microfibre implantation and electrostimulation.

 Deliverables

List of deliverables.
Generation of new affibodies binding bFGF or N-Cadherin Documents, reports 2020-01-23 08:43:01
Analytical and numerical models for the mechanical behaviour of the implanted MFs. Documents, reports 2020-01-23 08:43:01
Website and logo for NEUROFIBRES Websites, patent fillings, videos etc. 2020-01-23 08:43:01
Data management plan Open Research Data Pilot 2020-01-23 08:43:01

Take a look to the deliverables list in detail:  detailed list of Neurofibres deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Matteo Moncalero, Stefano Signetti, Barbara Mazzanti, Pietro Bruzzi, Nicola M. Pugno, Martino Colonna
Effect of material elastic properties and surface roughness on grip performances of ski boot soles under wet and icy conditions
published pages: 62-70, ISSN: 0169-8141, DOI: 10.1016/j.ergon.2017.04.004
International Journal of Industrial Ergonomics 61 2020-01-23
2017 Omar Tricinci, Tercio Terencio, Nicola Pugno, Francesco Greco, Barbara Mazzolai, Virgilio Mattoli
Air Trapping Mechanism in Artificial Salvinia-Like Micro-Hairs Fabricated via Direct Laser Lithography
published pages: 366, ISSN: 2072-666X, DOI: 10.3390/mi8120366
Micromachines 8/12 2020-01-23
2017 Zhang, Yi; Falco, P.; Wang, Y.; Barbieri, E.; Paris, O.; Terrill, N. J.; Falkenberg, G.; Pugno, N. M.; Gupta, H. S.
Towards in situ determination of 3D strain and reorientation in the interpenetrating nanofibre networks of cuticle
published pages: 11249 - 11260, ISSN: 2040-3372, DOI: 10.3204/PUBDB-2017-11841
Nanoscale 9 2020-01-23
2017 Martina Azzolini, Tommaso Morresi, Giovanni Garberoglio, Lucia Calliari, Nicola M. Pugno, Simone Taioli, Maurizio Dapor
Monte Carlo simulations of measured electron energy-loss spectra of diamond and graphite: Role of dielectric-response models
published pages: 299-309, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.03.041
Carbon 118 2020-01-23
2017 Panagiotis G. Karagiannidis, Stephen A. Hodge, Lucia Lombardi, Flavia Tomarchio, Nicolas Decorde, Silvia Milana, Ilya Goykhman, Yang Su, Steven V. Mesite, Duncan N. Johnstone, Rowan K. Leary, Paul A. Midgley, Nicola M. Pugno, Felice Torrisi, Andrea C. Ferrari
Microfluidization of Graphite and Formulation of Graphene-Based Conductive Inks
published pages: 2742-2755, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b07735
ACS Nano 11/3 2020-01-23
2017 Emiliano Lepore, Federico Bosia, Francesco Bonaccorso, Matteo Bruna, Simone Taioli, Giovanni Garberoglio, Andrea C Ferrari, Nicola Maria Pugno
Spider silk reinforced by graphene or carbon nanotubes
published pages: 31013, ISSN: 2053-1583, DOI: 10.1088/2053-1583/aa7cd3
2D Materials 4/3 2020-01-23
2018 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
A 2-D model for friction of complex anisotropic surfaces
published pages: 50-65, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.11.015
Journal of the Mechanics and Physics of Solids 112 2020-01-23
2017 F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni
Serpentine locomotion through elastic energy release
published pages: 20170055, ISSN: 1742-5689, DOI: 10.1098/rsif.2017.0055
Journal of The Royal Society Interface 14/130 2020-01-23
2017 Massimo Totaro, Nicola Maria Pugno, Barbara Mazzolai, Lucia Beccai
Micromechanical Analysis of Soft Tactile Sensors
published pages: 3, ISSN: 2296-8016, DOI: 10.3389/fmats.2017.00003
Frontiers in Materials 4 2020-01-23
2017 R.A. Bizao, T. Botari, E. Perim, Nicola M. Pugno, D.S. Galvao
Mechanical properties and fracture patterns of graphene (graphitic) nanowiggles
published pages: 431-437, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.04.018
Carbon 119 2020-01-23
2017 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Tuning friction with composite hierarchical surfaces
published pages: 261-267, ISSN: 0301-679X, DOI: 10.1016/j.triboint.2017.05.012
Tribology International 115 2020-01-23
2017 Prospero J. Taroni, Giovanni Santagiuliana, Kening Wan, Philip Calado, Manting Qiu, Han Zhang, Nicola M. Pugno, Matteo Palma, Natalie Stingelin-Stutzman, Martin Heeney, Oliver Fenwick, Mark Baxendale, Emiliano Bilotti
Toward Stretchable Self-Powered Sensors Based on the Thermoelectric Response of PEDOT:PSS/Polyurethane Blends
published pages: 1704285, ISSN: 1616-301X, DOI: 10.1002/adfm.201704285
Advanced Functional Materials 2020-01-23
2017 M. Miniaci, A. S. Gliozzi, B. Morvan, A. Krushynska, F. Bosia, M. Scalerandi, N. M. Pugno
Proof of Concept for an Ultrasensitive Technique to Detect and Localize Sources of Elastic Nonlinearity Using Phononic Crystals
published pages: 214301, ISSN: 0031-9007, DOI: 10.1103/PhysRevLett.118.214301
Physical Review Letters 118/21 2020-01-23
2017 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Tuning friction with composite hierarchical surfaces
published pages: 261-267, ISSN: 0301-679X, DOI: 10.1016/j.triboint.2017.05.012
Tribology International 115 2020-01-23
2018 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
A 2-D model for friction of complex anisotropic surfaces
published pages: 50-65, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.11.015
Journal of the Mechanics and Physics of Solids 112 2020-01-23
2017 Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1
Biomedical Microdevices 19/3 2020-01-23
2017 Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno
Nanomechanics of individual aerographite tetrapods
published pages: 14982, ISSN: 2041-1723, DOI: 10.1038/ncomms14982
Nature Communications 8 2020-01-23
2017 F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni
Serpentine locomotion through elastic energy release
published pages: 20170055, ISSN: 1742-5689, DOI: 10.1098/rsif.2017.0055
Journal of The Royal Society Interface 14/130 2020-01-23
2017 Stefano Signetti, Simone Taioli, Nicola M. Pugno
2D Material Armors Showing Superior Impact Strength of Few Layers
published pages: 40820-40830, ISSN: 1944-8244, DOI: 10.1021/acsami.7b12030
ACS Applied Materials & Interfaces 9/46 2020-01-23
2017 A. Taraghi Osguei, M.T. Ahmadian, M. Asghari, N.M. Pugno
Free vibration analysis of cylindrical panels with spiral cross section
published pages: 376-386, ISSN: 0020-7403, DOI: 10.1016/j.ijmecsci.2017.07.044
International Journal of Mechanical Sciences 133 2020-01-23
2017 Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte
YAP regulates cell mechanics by controlling focal adhesion assembly
published pages: 15321, ISSN: 2041-1723, DOI: 10.1038/ncomms15321
Nature Communications 8 2020-01-23
2017 Grazia Salerno, Alice Berardo, Tomoki Ozawa, Hannah M Price, Ludovic Taxis, Nicola M Pugno, Iacopo Carusotto
Spin–orbit coupling in a hexagonal ring of pendula
published pages: 55001, ISSN: 1367-2630, DOI: 10.1088/1367-2630/aa6c03
New Journal of Physics 19/5 2020-01-23
2017 Luca Valentini, Silvia Bittolo Bon, Miguel-Angel Lopez-Manchado, Lorenzo Mussolin, Nicola Pugno
Development of conductive paraffin/graphene films laminated on fluoroelastomers with high strain recovery and anti-corrosive properties
published pages: 254-261, ISSN: 0266-3538, DOI: 10.1016/j.compscitech.2017.06.023
Composites Science and Technology 149 2020-01-23
2017 M. Fraldi, G. Perrella, M. Ciervo, F. Bosia, N.M. Pugno
A hybrid deterministic-probabilistic approach to model the mechanical response of helically arranged hierarchical strands
published pages: 338-352, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.05.013
Journal of the Mechanics and Physics of Solids 106 2020-01-23
2017 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Hierarchical Spring-Block Model for Multiscale Friction Problems
published pages: 2845-2852, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.6b00709
ACS Biomaterials Science & Engineering 3/11 2020-01-23
2017 Q. Chen, F. Sun, Z. Y. Li, L. Taxis, N. Pugno
Nonlinear mechanics of a ring structure subjected to multi-pairs of evenly distributed equal radial forces
published pages: 942-953, ISSN: 0567-7718, DOI: 10.1007/s10409-017-0665-8
Acta Mechanica Sinica 33/5 2020-01-23
2017 Luca Valentini, Silvia Bittolo Bon, Nicola M. Pugno
Graphene and Carbon Nanotube Auxetic Rubber Bionic Composites with Negative Variation of the Electrical Resistance and Comparison with Their Nonbionic Counterparts
published pages: 1606526, ISSN: 1616-301X, DOI: 10.1002/adfm.201606526
Advanced Functional Materials 27/24 2020-01-23
2017 L. Felipe Barros, Juan P. Bolaños, Gilles Bonvento, Anne-Karine Bouzier-Sore, Angus Brown, Johannes Hirrlinger, Sergey Kasparov, Frank Kirchhoff, Anne N. Murphy, Luc Pellerin, Michael B. Robinson, Bruno Weber
Current technical approaches to brain energy metabolism
published pages: , ISSN: 0894-1491, DOI: 10.1002/glia.23248
Glia 2020-01-23
2017 Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno
Nanomechanics of individual aerographite tetrapods
published pages: 14982, ISSN: 2041-1723, DOI: 10.1038/ncomms14982
Nature Communications 8 2020-01-23
2017 Gianluca Costagliola, Federico Bosia, Nicola M. Pugno
Hierarchical Spring-Block Model for Multiscale Friction Problems
published pages: 2845-2852, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.6b00709
ACS Biomaterials Science & Engineering 3/11 2020-01-23
2017 Fabian Schütt, Stefano Signetti, Helge Krüger, Sarah Röder, Daria Smazna, Sören Kaps, Stanislav N. Gorb, Yogendra Kumar Mishra, Nicola M. Pugno, Rainer Adelung
Hierarchical self-entangled carbon nanotube tube networks
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01324-7
Nature Communications 8/1 2020-01-23
2017 Anja Scheller, Xianshu Bai, Frank Kirchhoff
The Role of the Oligodendrocyte Lineage in Acute Brain Trauma
published pages: 2479-2489, ISSN: 0364-3190, DOI: 10.1007/s11064-017-2343-4
Neurochemical Research 42/9 2020-01-23
2016 D. Misseroni, L. Afferrante, G. Carbone, N. M. Pugno
Non-linear double-peeling: Experimental vs. theoretical predictions
published pages: 46-57, ISSN: 0021-8464, DOI: 10.1080/00218464.2016.1255849
The Journal of Adhesion 94/1 2020-01-23
2017 Iryna Polishchuk, Avigail Aronhime Bracha, Leonid Bloch, Davide Levy, Stas Kozachkevich, Yael Etinger-Geller, Yaron Kauffmann, Manfred Burghammer, Carlotta Giacobbe, Julie Villanova, Gordon Hendler, Chang-Yu Sun, Anthony J. Giuffre, Matthew A. Marcus, Lakshminath Kundanati, Paul Zaslansky, Nicola M. Pugno, Pupa U. P. A. Gilbert, Alex Katsman, Boaz Pokroy
Coherently aligned nanoparticles within a biogenic single crystal: A biological prestressing strategy
published pages: 1294-1298, ISSN: 0036-8075, DOI: 10.1126/science.aaj2156
Science 358/6368 2020-01-23

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