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RAMSES SIGNED

Reactivity and Assembly of Multifunctional, Stimuli-responsive Encapsulation Structures

Total Cost €

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EC-Contrib. €

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Partnership

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 RAMSES project word cloud

Explore the words cloud of the RAMSES project. It provides you a very rough idea of what is the project "RAMSES" about.

artificial    tuning    functional    structures    basis    nature    fine    demonstrates    nanotechnology    reaction    covalently    functionalized    architectures    regulation    binding    host    blocks    pd2ligand4    serve    architecture    light    grouped    mechanisms    chirality    line    receptors    feedback    reported    programmed    lies    selective    allosteric    assembly    heteroleptic    promise    progress    supramolecular    regulate    cages    metal    biopolymer    substrates    emerges    transform    ion    folding    chambers    sites    achievements    joined    specialized    breakthrough    nanoscopic    catalysis    components    scientists    molecular    steric    cavity    material    advent    equipped    ligands    precisely    entities    strategies    cooperative    transformation    complicated    give    guest    multifunctional    drug    individual    endohedral    self    interplay    chemical    arranged    electronics    signal    diagnostics    ligand    platform    chemistry    construct    adjustable    switching    photo    recognize    biochemical    action    connectivities    combinations    single    impressive    modular    systems    loops    mono    complexity    sort    enzymes    chain    inspired    building    redox    function    group    medicine    substances    sophisticated    enzyme    combined    photonics    science   

Project "RAMSES" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAT DORTMUND 

Organization address
address: AUGUST SCHMIDT STRASSE 4
city: DORTMUND
postcode: 44227
website: www.tu-dortmund.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.ccb.tu-dortmund.de/fb03/en/Fields_of_research/AC/Clever/ERC-RAMSES/index.html
 Total cost 1˙982˙500 €
 EC max contribution 1˙982˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAT DORTMUND DE (DORTMUND) coordinator 1˙982˙500.00

Map

 Project objective

In biochemical systems, combinations of specialized molecular entities are precisely arranged to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates in enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Control mechanisms based on the cooperative binding of signal substances regulate the enzyme’s action, and complicated feedback loops may apply. Since the advent of supramolecular chemistry, scientists construct artificial systems with ever increasing complexity and functionality that promise to serve as the basis for future developments in bottom-up nanotechnology with applications in medicine (drug delivery), diagnostics, catalysis, material science and molecular photonics/electronics. Self-assembly of functional entities with pre-programmed connectivities has produced an impressive line-up of nanoscopic architectures such as coordination cages that recognize and transform molecular substrates. Most of these systems are based on one sort of ligand, joined by one kind of metal ion. My group has reported a number of cages, each equipped with a unique, single function such as chirality, redox-activity, light-switching, allosteric regulation or endohedral binding sites. While all these mono-functionalized cages contribute to the progress of supramolecular architecture, nature demonstrates that the key to the most sophisticated systems lies in multi-functionalized structures. As breakthrough strategies for achieving this level of complexity with artificial systems we propose: 1) Heteroleptic coordination of ligands by a [Pd2Ligand4]-platform-specific way of steric fine-tuning 2) Biopolymer-inspired folding of a modular chain of covalently joined building blocks Combined with our recent achievements in host-guest switching, we aim at adjustable receptors, controllable molecular reaction chambers and multifunctional photo/redox systems

 Publications

year authors and title journal last update
List of publications.
2020 Philip M. Punt, Lukas M. Stratmann, Sinem Sevim, Lena Knauer, Carsten Strohmann, Guido H. Clever
Heteroleptic Coordination Environments in Metal-Mediated DNA G-Quadruplexes
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2020.00026
Frontiers in Chemistry 8 2020-02-28
2019 Bin Chen, Shinnosuke Horiuchi, Julian J. Holstein, Jacopo Tessarolo, Guido H. Clever
Tunable Fullerene Affinity of Cages, Bowls and Rings Assembled by Pd(II) Coordination Sphere Engineering
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201903317
Chemistry – A European Journal 2019-10-29
2018 Rongmei Zhu, Witold M. Bloch, Julian J. Holstein, Soham Mandal, Lars V. Schäfer, Guido H. Clever
Donor-Site-Directed Rational Assembly of Heteroleptic cis -[Pd 2 L 2 L′ 2 ] Coordination Cages from Picolyl Ligands
published pages: 12976-12982, ISSN: 0947-6539, DOI: 10.1002/chem.201802188
Chemistry - A European Journal 24/49 2019-08-29
2017 Witold M. Bloch, Julian J. Holstein, Wolf Hiller, Guido H. Clever
Morphological Control of Heteroleptic cis - and trans -Pd 2 L 2 L′ 2 Cages
published pages: 8285-8289, ISSN: 1433-7851, DOI: 10.1002/anie.201702573
Angewandte Chemie International Edition 56/28 2019-09-02
2019 Bin Chen, Julian J. Holstein, Shinnosuke Horiuchi, Wolf G. Hiller, Guido H. Clever
Pd(II) Coordination Sphere Engineering: Pyridine Cages, Quinoline Bowls, and Heteroleptic Pills Binding One or Two Fullerenes
published pages: 8907-8913, ISSN: 0002-7863, DOI: 10.1021/jacs.9b02207
Journal of the American Chemical Society 141/22 2019-09-04
2017 Witold M. Bloch, Guido H. Clever
Integrative self-sorting of coordination cages based on ‘naked’ metal ions
published pages: 8506-8516, ISSN: 1359-7345, DOI: 10.1039/c7cc03379f
Chemical Communications 53/61 2019-06-18
2019 Thorben R. Schulte, Julian J. Holstein, Guido H. Clever
Chiral Self-Discrimination and Guest Recognition in Helicene-Based Coordination Cages
published pages: 5562-5566, ISSN: 1433-7851, DOI: 10.1002/anie.201812926
Angewandte Chemie International Edition 58/17 2019-08-05
2019 Ru‐Jin Li, Muxin Han, Jacopo Tessarolo, Julian J. Holstein, Jens Lübben, Birger Dittrich, Christian Volkmann, Maik Finze, Carsten Jenne, Guido H. Clever
Successive Photoswitching and Derivatization Effects in Photochromic Dithienylethene‐Based Coordination Cages
published pages: , ISSN: 2367-0932, DOI: 10.1002/cptc.201900038
ChemPhotoChem 2019-08-05
2019 Ru-Jin Li, Julian. J. Holstein, Wolf G. Hiller, Joakim Andréasson, Guido H. Clever
Mechanistic Interplay between Light Switching and Guest Binding in Photochromic [Pd 2 Dithienylethene 4 ] Coordination Cages
published pages: 2097-2103, ISSN: 0002-7863, DOI: 10.1021/jacs.8b11872
Journal of the American Chemical Society 141/5 2019-05-22
2018 Sonja Pullen, Guido H. Clever
Mixed-Ligand Metal–Organic Frameworks and Heteroleptic Coordination Cages as Multifunctional Scaffolds—A Comparison
published pages: 3052-3064, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.8b00415
Accounts of Chemical Research 51/12 2019-05-22
2018 Rongmei Zhu, Witold M. Bloch, Julian J. Holstein, Soham Mandal, Lars V. Schäfer, Guido H. Clever
Donor-Site-Directed Rational Assembly of Heteroleptic cis -[Pd 2 L 2 L′ 2 ] Coordination Cages from Picolyl Ligands
published pages: 12976-12982, ISSN: 0947-6539, DOI: 10.1002/chem.201802188
Chemistry - A European Journal 24/49 2019-05-22
2018 Subhadeep Saha, Björn Holzapfel, Yen-Ting Chen, Kai Terlinden, Pascal Lill, Christos Gatsogiannis, Heinz Rehage, Guido H. Clever
Rational Design of an Amphiphilic Coordination Cage-Based Emulsifier
published pages: 17384-17388, ISSN: 0002-7863, DOI: 10.1021/jacs.8b10991
Journal of the American Chemical Society 140/50 2019-05-22

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