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MULTIFUNSOME TERMINATED

Anti-EGFR Monoclonal Antibody Conjugated Thermoresponsive Liposome for Triple Negative Breast Cancer Thermo-Chemotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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 MULTIFUNSOME project word cloud

Explore the words cloud of the MULTIFUNSOME project. It provides you a very rough idea of what is the project "MULTIFUNSOME" about.

heating    therapeutic    spio    induce    multicore    liposomes    multifunsome    magnetic    physical    membrane    simultaneously    alternating    minimize    liposomal    efficiency    maximize    treatment    egfr    manipulated    cells    subtype    release    women    chemical    dose    fellowship    antibody    cargo    superparamagnetic    co    readily    fellow    proposes    permeability    nanoparticles    internalization    epidermal    encapsulation    monoclonal    critical    triple    death    training    drug    collaborations    anti    size    efficient    iron    combining    breast    enhanced    prognosis    options    chemotherapy    limited    conjugated    negative    receptor    intracellularly    therapy    formulation    anticancer    multidisciplinary    mh    influence    thermal    expertise    effectiveness    impacts    subtypes    effect    potentially    spios    conjugating    liposome    generate    overexpressing    synergistically    oxide    lipid    sensitive    content    thermo    tnbc    trigger    nano    drugs    core    poorer    cancer    concurrent    histological    aggressive    thermoresponsive    efficacious    area    hyperthermia    serve   

Project "MULTIFUNSOME" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

In Europe, breast cancer is by far the most important cause of cancer death among women. In particular, triple negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and associated with poorer prognosis than other breast cancer subtypes. MULTIFUNSOME proposes the use of an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody-conjugated thermoresponsive liposome to deliver simultaneously an anticancer drug and superparamagnetic iron oxide nanoparticles (SPIO) to TNBC cells for thermo-chemotherapy. We will investigate: 1) the effect of combining anti-EGFR targeting and magnetic hyperthermia (MH) on TNBC in such thermo-chemotherapy and 2) how chemical-physical properties of the SPIOs and liposomes influence the therapeutic activity of the formulation. By conjugating anti-EGFR monoclonal antibody to a liposomal delivery system for targeting, drug and SPIO internalization into EGFR overexpressing TNBC cells will be greatly enhanced. SPIO co-encapsulation in the drug nano-cargo will induce a thermal dose to the TNBC cells when an alternating magnetic field is applied. MH will make TNBC cells more sensitive to chemotherapy and trigger the release of drugs intracellularly by enhancing the lipid membrane permeability. As a result, the effectiveness of chemotherapy could be synergistically enhanced by the concurrent application of MH and chemotherapy. The core size of SPIO will serve as a design parameter that can be readily manipulated to maximize the heating efficient of the multicore SPIO so as to minimize the necessary iron oxide content and maximize the drug encapsulation efficiency. The fellowship program will include a comprehensive training which will help the fellow to develop a unique multidisciplinary expertise. Furthermore, the project will generate important knowledge, impacts and collaborations in the European Research Area and could potentially address the critical need for a more efficacious TNBC therapy.

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The information about "MULTIFUNSOME" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2025-10-27 21:27:41) correctly updated