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MULTIFUNSOME TERMINATED

Anti-EGFR Monoclonal Antibody Conjugated Thermoresponsive Liposome for Triple Negative Breast Cancer Thermo-Chemotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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 MULTIFUNSOME project word cloud

Explore the words cloud of the MULTIFUNSOME project. It provides you a very rough idea of what is the project "MULTIFUNSOME" about.

efficacious    histological    generate    critical    liposome    fellow    synergistically    monoclonal    physical    negative    nanoparticles    subtypes    trigger    subtype    collaborations    oxide    minimize    enhanced    therapeutic    serve    women    concurrent    anti    nano    receptor    release    effectiveness    proposes    anticancer    multicore    triple    dose    superparamagnetic    overexpressing    conjugated    efficient    training    maximize    membrane    drug    formulation    impacts    spio    egfr    thermo    hyperthermia    poorer    epidermal    influence    effect    heating    drugs    permeability    therapy    area    intracellularly    breast    efficiency    limited    multidisciplinary    potentially    prognosis    chemical    liposomal    cargo    multifunsome    aggressive    readily    death    tnbc    size    conjugating    core    fellowship    induce    antibody    mh    simultaneously    liposomes    chemotherapy    sensitive    encapsulation    expertise    thermoresponsive    options    lipid    content    magnetic    thermal    spios    iron    cells    combining    treatment    cancer    internalization    manipulated    co    alternating   

Project "MULTIFUNSOME" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

In Europe, breast cancer is by far the most important cause of cancer death among women. In particular, triple negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and associated with poorer prognosis than other breast cancer subtypes. MULTIFUNSOME proposes the use of an anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody-conjugated thermoresponsive liposome to deliver simultaneously an anticancer drug and superparamagnetic iron oxide nanoparticles (SPIO) to TNBC cells for thermo-chemotherapy. We will investigate: 1) the effect of combining anti-EGFR targeting and magnetic hyperthermia (MH) on TNBC in such thermo-chemotherapy and 2) how chemical-physical properties of the SPIOs and liposomes influence the therapeutic activity of the formulation. By conjugating anti-EGFR monoclonal antibody to a liposomal delivery system for targeting, drug and SPIO internalization into EGFR overexpressing TNBC cells will be greatly enhanced. SPIO co-encapsulation in the drug nano-cargo will induce a thermal dose to the TNBC cells when an alternating magnetic field is applied. MH will make TNBC cells more sensitive to chemotherapy and trigger the release of drugs intracellularly by enhancing the lipid membrane permeability. As a result, the effectiveness of chemotherapy could be synergistically enhanced by the concurrent application of MH and chemotherapy. The core size of SPIO will serve as a design parameter that can be readily manipulated to maximize the heating efficient of the multicore SPIO so as to minimize the necessary iron oxide content and maximize the drug encapsulation efficiency. The fellowship program will include a comprehensive training which will help the fellow to develop a unique multidisciplinary expertise. Furthermore, the project will generate important knowledge, impacts and collaborations in the European Research Area and could potentially address the critical need for a more efficacious TNBC therapy.

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The information about "MULTIFUNSOME" are provided by the European Opendata Portal: CORDIS opendata.

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