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FLEXNEURO SIGNED

Flexible and robust nervous system function from reconfiguring networks

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FLEXNEURO" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙299˙191 €
 EC max contribution 1˙299˙191 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙299˙191.00

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 Project objective

It is now possible to monitor and manipulate neurons in live, awake animals, revealing how patterns of neural activity represent information and give rise to behaviour. Very recent experiments show that many circuits have physiology and connectivity that is highly variable and that changes continually, even when an animal’s behaviour and environment are stable. Existing theories of brain function assume that neural circuit parameters only change as required during learning and development. This paradigm cannot explain how consistent behaviour can emerge from circuits that continually reconfigure, nor what mechanisms might drive variability and continual change. Understanding this deep puzzle requires new theory and new ways to interpret experimental data. I will develop a theory of reconfiguring circuits by significantly generalizing my previous work that uses control theory to show how network activity can be maintained in spite of variability and continual turnover of crucial circuit components. We will analyse how biological plasticity mechanisms steer collective properties of neurons and circuits toward functional states without requiring individual parameters to be fixed, resulting in circuit models with consistent output but variable and mutable internal structures. In close collaboration with leading experimentalists we will challenge these modelling principles to account for new findings which reveal that navigation, sensory percepts and learned associations are underpinned by surprisingly dynamic, variable circuit connectivity and physiology. This will generate new, exciting questions that will drive experiments and theory together: how can known plasticity mechanisms generate reconfigurable neural representations? Do continually reconfiguring networks possess unique functional flexibility and robustness, and are they vulnerable to specific pathologies? And how can we design new experiments to test theories of robust, reconfigurable networks?

 Publications

year authors and title journal last update
List of publications.
2019 Srinivas Gorur-Shandilya, Eve Marder, Timothy O’Leary
Homeostatic plasticity rules that compensate for cell size are susceptible to channel deletion
published pages: , ISSN: , DOI: 10.1101/753608
2020-01-22
2019 Saeed Aljaberi, Timothy O\'Leary, Fulvio Forni
Qualitative behavior and robustness of dendritic trafficking
published pages: , ISSN: , DOI:
IEEE Conference on Decision and Control (CDC) Friday December 13, 2019 2020-01-22
2019 Adrianna R. Loback, Michael E. Rule, Dhruva V. Raman, Laura N. Driscoll, Christopher D. Harvey, Timothy O\'Leary
Stable task information from an unstable neural population
published pages: , ISSN: , DOI: 10.1101/796334
2020-01-22
2019 Jacob Ratliff, Eve Marder, Timothy O\'Leary
Neural circuit robustness to acute, global physiological perturbations
published pages: , ISSN: , DOI:
2020-01-22
2019 Michael E Rule, Timothy O’Leary, Christopher D Harvey
Causes and consequences of representational drift
published pages: 141-147, ISSN: 0959-4388, DOI: 10.1016/j.conb.2019.08.005
Current Opinion in Neurobiology 58 2020-01-22
2018 Timothy O’Leary
Homeostasis, failure of homeostasis and degenerate ion channel regulation
published pages: 129-138, ISSN: 2468-8673, DOI: 10.1016/j.cophys.2018.01.006
Current Opinion in Physiology 2 2020-01-22
2018 Timothy O\'Leary, Dhruva Raman
Fundamental bounds on learning performance in neural circuits
published pages: , ISSN: , DOI: 10.1101/508994
2020-01-22

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