Explore the words cloud of the LIVERHOPE project. It provides you a very rough idea of what is the project "LIVERHOPE" about.
The following table provides information about the project.
Coordinator |
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://www.liverhope-h2020.eu |
Total cost | 5˙998˙800 € |
EC max contribution | 5˙998˙800 € (100%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-SC1-2016-RTD |
Funding Scheme | RIA |
Starting year | 2017 |
Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Take a look of project's partnership.
Liver cirrhosis is a very common chronic disease and one of the leading causes of death in European. Moreover, cirrhosis has a marked impact in patients quality of life and represents a major burden for health systems. Treatment of cirrhosis is currently based on symptomatic management of complications and has not changed substantially in the last 20 years. There is an unmet need for therapies that target the pathobiology of cirrhosis. The objective of LIVERHOPE project is to evaluate a novel therapeutic strategy for patients with cirrhosis based on a combination of rifaximin and simvastatin, targeting the main pathophysiological mechanisms of disease progression , namely the impairment in the gut-liver axis and the persistent hepatic and systemic inflammatory response. This dual therapeutic approach is supported by preclinical data showing excellent and very promising results. We will perform two randomized double-blind trials to investigate safety, tolerability and efficacy of combination of simvastatin plus rifaximin in patients with decompensated cirrhosis in 5 EU countries (285 patients will be enrolled in two trials in DE, ES, FR, IT, UK). The expected impact is to halt progression to acute-on-chronic liver failure, the main cause of death, to decrease complications of the disease, to reduce hospital readmissions, to improve cost-effectiveness of therapy. Our final aim is to improve patients quality-of-life and increase survival as patients‘ care is the core of LIVERHOPE. Within the project we will also investigate biomarkers of response to treatment and disease progression that can be useful in clinical practice for improving the treatment of patients. We will invest our effort also in communication and dissemination activities for increasing awareness about chronic liver diseases in European countries so that preventive measures can be established to decrease the burden of cirrhosis and reduce social stigmatization of patients with chronic liver diseases.
Communication material for patient associations, patients and families enrolled_I | Demonstrators, pilots, prototypes | 2020-03-17 14:18:44 |
Interim analysis report on cost-effectiveness and cost-utility, included budget impact analysis and sensivity analysis, both univariate and probabilistic | Documents, reports | 2020-03-17 14:18:44 |
Space for LIVERHOPE on the ELPA web sit | Websites, patent fillings, videos etc. | 2020-03-17 14:18:44 |
Presentation of LIVERHOPE at ELPA Symposium and possible other venue | Demonstrators, pilots, prototypes | 2020-03-17 14:18:44 |
Project web site | Websites, patent fillings, videos etc. | 2020-03-17 14:18:44 |
Initial dissemination plan | Documents, reports | 2020-03-17 14:18:44 |
Publications and material for communication (flyers, press release, videos, seminars, publications)_I | Websites, patent fillings, videos etc. | 2020-03-17 14:18:44 |
Project visual identity | Documents, reports | 2020-03-17 14:18:44 |
Take a look to the deliverables list in detail: detailed list of LIVERHOPE deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Elisa Pose, Jonel Trebicka, Rajeshwar P. Mookerjee, Paolo Angeli, Pere Ginès Statins: old drugs as new therapy for liver diseases? published pages: , ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.07.019 |
Journal of Hepatology | 2020-03-17 |
2019 |
Cristina Solé, Elsa Solà , Patricia Huelin, Marta Carol, Rebeca Moreira, Unai Cereijo, Joséâ€Manuel Mas, Isabel Graupera, Elisa Pose, Laura Napoleone, Gloria dePrada, Adrià Juanola, Núria Fabrellas, Ferran Torres, Manuel Moralesâ€Ruiz, Judith Farrés, Wladimiro Jiménez, Pere Ginès Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival published pages: 1246-1255, ISSN: 1478-3223, DOI: 10.1111/liv.14037 |
Liver International 39/7 | 2020-03-17 |
2020 |
Elisa Pose, Laura Napoleone, Ahmed Amin, Daniela Campion, César Jimenez, Salvatore Piano, Olivier Roux, Frank Erhard Uschner, Koos de Wit, Giacomo Zaccherini, Carlo Alessandria, Paolo Angeli, Mauro Bernardi, Ulrich Beuers, Paolo Caraceni, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Raúl J Andrade, Marta Carol, Judit Pich, Juan Ferrero, Gema Domenech, Marta Llopis, Fer Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial published pages: 31-41, ISSN: 2468-1253, DOI: 10.1016/s2468-1253(19)30320-6 |
The Lancet Gastroenterology & Hepatology 5/1 | 2020-03-17 |
2017 |
Elsa Solà , Pere Ginès Pro: Acute-on-chronic liver failure published pages: 1318-1324, ISSN: 1527-6465, DOI: 10.1002/lt.24812 |
Liver Transplantation 23/10 | 2020-03-17 |
2020 |
Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappe, Vanessa Esnault, Sabine Grafâ€Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L. Dols, Elsa Solà , Elisa Pose, Paolo Caraceni, Victor Vargas, Carlo Alessandria, Ulrich Beuers, Jonel Trebicka, François Durand, Rajeshwar Mookerjee, Paolo Angeli, Marko Kore Nursing care of patients with cirrhosis published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.31117 |
Hepatology | 2020-03-17 |
2018 |
Pere Ginès, Shiv Sarin More Than Meets the Eye in Using Interleukin 6 as a Marker of Inflammation and Prognostic Factor for Patients With Cirrhosis published pages: 630-632, ISSN: 1542-3565, DOI: 10.1016/j.cgh.2017.12.031 |
Clinical Gastroenterology and Hepatology 16/5 | 2020-03-17 |
2017 |
Ruben Hernaez, Elsa Solà , Richard Moreau, Pere Ginès Acute-on-chronic liver failure: an update published pages: 541-553, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312670 |
Gut 66/3 | 2020-03-17 |
2018 |
Cristina Solé, Elisa Pose, Elsa Solà , Pere Ginès Hepatorenal syndrome in the era of acute kidney injury published pages: , ISSN: 1478-3223, DOI: 10.1111/liv.13893 |
Liver International | 2020-03-17 |
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The information about "LIVERHOPE" are provided by the European Opendata Portal: CORDIS opendata.