Explore the words cloud of the MERA project. It provides you a very rough idea of what is the project "MERA" about.
The following table provides information about the project.
HUMBOLDT-UNIVERSITAET ZU BERLIN
|Coordinator Country||Germany [DE]|
|Total cost||2˙398˙750 €|
|EC max contribution||2˙398˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||HUMBOLDT-UNIVERSITAET ZU BERLIN||DE (BERLIN)||coordinator||2˙398˙750.00|
'Channelrhodopsin, which was discovered and described as a light-gated ion channel in my laboratory, has revolutionized the field of neuroscience over the past decade by enabling researchers to specifically activate selected neurons in a large ensemble of neuronal cells with short light flashes, a technology we now call 'Optogenetics.' However, though highly desirable, the inactivation of specific cells using moderate or low light intensities is not yet possible. The recently discovered rhodopsin-guanylyl-cyclase (RhGC) of the fungus Blastocladiella emersonii offers an elegant solution to this problem. Moreover, RhGC is a totally novel and uncharacterized sensory photoreceptor, and the first member of an enzyme rhodopsin family that urgently awaits in-depth characterization. Accordingly, the goal of the “mechanism of enzyme rhodopsin activation” (MERA) proposal is to obtain a comprehensive understanding of this novel photoreceptor, and to determine its functionality for broad application in optogenetics and other research fields. The MERA project is subdivided into four objectives. The first objective is the characterization and engineering of RhGC in cell lines and neurons as well as coexpression of RhGC with a cGMP-gated K channel to develop a 'Light-Hypopolarizer' for cell inactivation. The second objective is to understand the dynamics of RhGC using a variety of biophysical technologies including time resolved UV-vis, FTIR, and Raman and EPR spectroscopy. A third objective is the generation of crystals for X-ray crystallography and the development of a three dimensional RhGC model. The fourth and final objective is the computer-aided conversion of RhGC into a rhodopsin-phosphodiesterase (RhPDE) for down-regulation of the second messenger cGMP and/or cAMP using light. The ultimate outcome will be a detailed understanding of a novel class of sensory photoreceptors with new perspectives for broad optogenetic applications.'
|year||authors and title||journal||last update|
Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann
Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3â€‰Ã… structure of the adenylyl cyclase domain
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04428-w
|Nature Communications 9/1||2019-06-13|
Alfons Penzkofer, Ulrike Scheib, Katja Stehfest, Peter Hegemann
Absorption and Emission Spectroscopic Investigation of Thermal Dynamics and Photo-Dynamics of the Rhodopsin Domain of the Rhodopsin-Guanylyl Cyclase from the Nematophagous Fungus Catenaria anguillulae
published pages: 2099, ISSN: 1422-0067, DOI: 10.3390/ijms18102099
|International Journal of Molecular Sciences 18/10||2019-06-13|
Biochemische und biophysikalische Charakterisierung von Rhodopsin-Guanylylzyklasen.
published pages: , ISSN: , DOI:
Shatanik Mukherjee, Peter Hegemann, Matthias Broser
Enzymerhodopsins: novel photoregulated catalysts for optogenetics
published pages: 118-126, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.02.003
|Current Opinion in Structural Biology 57||2019-06-06|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MERA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MERA" are provided by the European Opendata Portal: CORDIS opendata.