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BYPASSWITHOUTSURGERY SIGNED

Reaching the effects of gastric bypass on diabetes and obesity without surgery

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BYPASSWITHOUTSURGERY" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙911˙072.00
2    REGION HOVEDSTADEN DK (HILLEROD) participant 588˙927.00

Map

 Project objective

Gastric bypass surgery results in massive weight loss and diabetes remission. The effect is superior to intensive medical treatment, showing that there are mechanisms within the body that can cure diabetes and obesity. Revealing the nature of these mechanisms could lead to new, cost-efficient, similarly effective, non-invasive treatments of these conditions. The hypothesis is that hyper-secretion of a number of gut hormones mediates the effect of surgery, as indicated by a series of our recent studies, demonstrating that hypersecretion of GLP-1, a hormone discovered in my laboratory and basis for the antidiabetic medication of millions of patients, is essential for the improved insulin secretion and glucose tolerance. But what are the mechanisms behind the up to 30-fold elevations in secretion of these hormones following surgery? Constantly with a translational scope, all elements involved in these responses will be addressed in this project, from detailed analysis of food items responsible for hormone secretion, to identification of the responsible regions of the gut, and to the molecular mechanisms leading to hypersecretion. Novel approaches for studies of human gut hormone secreting cells, including specific expression analysis, are combined with our advanced and unique isolated perfused gut preparations, the only tool that can provide physiologically relevant results with a translational potential regarding regulation of hormone secretion in the gut. This will lead to further groundbreaking experimental attempts to mimic and engage the identified mechanisms, creating similar hypersecretion and obtaining similar improvements as the operations in patients with obesity and diabetes. Based on our profound knowledge of gut hormone biology accumulated through decades of intensive and successful research and our successful elucidation of the antidiabetic actions of gastric bypass surgery, we are in a unique position to reach this ambitious goal.

 Publications

year authors and title journal last update
List of publications.
2018 Charlotte Bayer Christiansen, Maria Buur Nordskov Gabe, Berit Svendsen, Lars Ove Dragsted, Mette Marie Rosenkilde, Jens Juul Holst
The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon
published pages: G53-G65, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00346.2017
American Journal of Physiology-Gastrointestinal and Liver Physiology 315/1 2019-06-13
2018 Rune E. Kuhre, Nicolai J. Wewer Albrechtsen, Olav Larsen, Sara L. Jepsen, Emilie Balk-Møller, Daniel B. Andersen, Carolyn F. Deacon, Kristina Schoonjans, Frank Reimann, Fiona M. Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas
published pages: 84-95, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2018.03.007
Molecular Metabolism 11 2019-06-13
2017 Rune E. Kuhre, Charlotte B. Christiansen, Monika Y. Saltiel, Nicolai J. Wewer Albrechtsen, Jens J. Holst
On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat
published pages: e13507, ISSN: 2051-817X, DOI: 10.14814/phy2.13507
Physiological Reports 5/23 2019-06-13
2018 Jens Juul Holst, Sten Madsbad, Kirstine N. Bojsen-Møller, Maria Saur Svane, Nils Bruun Jørgensen, Carsten Dirksen, Christoffer Martinussen
Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss
published pages: 708-714, ISSN: 1550-7289, DOI: 10.1016/j.soard.2018.03.003
Surgery for Obesity and Related Diseases 14/5 2019-06-13
2018 Natalia Petersen, Thomas M. Frimurer, Marianne Terndrup Pedersen, Kristoffer L. Egerod, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Anne Grapin-Botton, Kim B. Jensen, Thue W. Schwartz
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
published pages: 1164-1176.e2, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.06.039
Gastroenterology 155/4 2019-08-29
2018 A. Lautenbach, M. Wernecke, N. Riedel, J. Veigel, J. Yamamura, S. Keller, R. Jung, P. Busch, O. Mann, F.K. Knop, J.J. Holst, J.J. Meier, J. Aberle
Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss
published pages: e3025, ISSN: 1520-7552, DOI: 10.1002/dmrr.3025
Diabetes/Metabolism Research and Reviews 34/7 2019-08-29

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