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ByAxon SIGNED

Towards an active bypass for neural reconnection

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ByAxon" data sheet

The following table provides information about the project.

Coordinator
FUNDACION IMDEA NANOCIENCIA 

Organization address
address: CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9
city: MADRID
postcode: 28049
website: http://www.nanociencia.imdea.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://byaxon-project.eu/
 Total cost 3˙752˙057 €
 EC max contribution 3˙752˙057 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION IMDEA NANOCIENCIA ES (MADRID) coordinator 1˙212˙500.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 1˙161˙903.00
3    SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE IT (TRIESTE) participant 636˙960.00
4    Mfd-diagnostics GmbH DE (Wendelsheim) participant 287˙500.00
5    SERVICIO DE SALUD DE CASTILLA LA MANCHA ES (TOLEDO) participant 243˙569.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 209˙624.00

Map

 Project objective

ByAxon is devoted to the development of a new generation of sensors and electrodes based on nanotechnology materials for neural interfacing. We aim to design and build a prototype of an active implant that could work directly at the spinal cord (SC) level. This implant will be primary focused on restoring the transmission of electrical signals in the injured SC, acting as an active local bypass, something not possible with current technology. Further applications might include deep brain stimulation or retinal implants, among others. Current neural interfacing approaches are based on detecting electric potentials at the brain level, and/or triggering functional electrical stimulation (FES) through electrodes at muscular or SC levels. Important present drawbacks are the large number of cables and electrodes they require and, specially, the lack of sensory feedback. The ultimate non-contact sensing devices (magnetoencephalography) detect magnetic-field pulses generated by potentials at the brain, but require cryogenic temperatures, and, hence, are not portable. We will exploit here the enhanced properties of nanostructured materials to develop improved room temperature magnetoresistance-based high-resolution magnetic sensors. This will allow tackling not only the brain but also the SC directly. We pursuit a novel integrated interface comprising both sensing and stimulation at the SC level. To reach this aim, we will develop FES electrodes of enhanced adhesion and efficiency by using nanowire coatings. ByAxon is supported by an interdisciplinary consortium, going from material scientists and electronic experts to biologists and clinicians. Our nanotechnology-based approach offers a novel perspective and will be complementary to, but independent from, present neural regenerative techniques. Our technology promises significant outcomes towards the development of an active local bypass and it has the potential to provide much-needed breakthroughs in future neuromedicine.

 Deliverables

List of deliverables.
Dissemination and Exploitation Plan Documents, reports 2019-06-06 16:04:37
Report on electrophysiological tests 2 Documents, reports 2019-06-06 16:04:30
Report on the magnetic sensor and nanostructured electrode development Documents, reports 2019-05-24 11:49:59
Functional artificial neuron Demonstrators, pilots, prototypes 2019-05-24 11:49:52
First nanostructured electrode Demonstrators, pilots, prototypes 2019-05-24 11:49:54
Social network sites Websites, patent fillings, videos etc. 2019-05-24 11:49:49
First four-bridge magnetic sensor Demonstrators, pilots, prototypes 2019-05-24 11:49:53
Website and project logo Websites, patent fillings, videos etc. 2019-05-24 11:50:01
First nanostructured electrode on neuron-accesible substrates Demonstrators, pilots, prototypes 2019-05-24 11:49:59
Public report on biocompatibility in vitro 1 Documents, reports 2019-05-24 11:49:49

Take a look to the deliverables list in detail:  detailed list of ByAxon deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Ankor González-Mayorga, Elisa López-Dolado, María C. Gutiérrez, Jorge E. Collazos-Castro, M. Luisa Ferrer, Francisco del Monte, María C. Serrano
Favorable Biological Responses of Neural Cells and Tissue Interacting with Graphene Oxide Microfibers
published pages: 8253-8263, ISSN: 2470-1343, DOI: 10.1021/acsomega.7b01354
ACS Omega 2/11 2019-06-11
2017 Olivier Rousseau, Stéphane Flament, Bruno Guillet, Marc Lam Chok Sing, Laurence Méchin
Magnetic Sensors Based on AMR Effect in LSMO Thin Films
published pages: 635, ISSN: 2504-3900, DOI: 10.3390/proceedings1040635
Proceedings 1/4 2019-06-11
2018 Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato, Laura Ballerini
Nanostructures to Engineer 3D Neural-Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments
published pages: 1700550, ISSN: 1616-301X, DOI: 10.1002/adfm.201700550
Advanced Functional Materials 28/12 2019-06-11
2017 Paolo Perna, Davide Maccariello, Fernando Ajejas, Ruben Guerrero, Laurence Méchin, Stephane Flament, Jacobo Santamaria, Rodolfo Miranda, Julio Camarero
Engineering Large Anisotropic Magnetoresistance in La 0.7 Sr 0.3 MnO 3 Films at Room Temperature
published pages: 1700664, ISSN: 1616-301X, DOI: 10.1002/adfm.201700664
Advanced Functional Materials 27/26 2019-06-11
2018 Sandeep Kumar Chaluvadi, Fernando Ajejas, Pasquale Orgiani, Olivier Rousseau, Giovanni Vinai, Aleksandr Yu Petrov, Piero Torelli, Alain Pautrat, Julio Camarero, Paolo Perna, Laurence Mechin
Room temperature biaxial magnetic anisotropy in La 0.67 Sr 0.33 MnO 3 thin films on SrTiO 3 buffered MgO (001) substrates for spintronic applications
published pages: 52403, ISSN: 0003-6951, DOI: 10.1063/1.5020072
Applied Physics Letters 113/5 2019-05-15

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