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Bio-ICD SIGNED

Biological auto-detection and termination of heart rhythm disturbances

Total Cost €

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EC-Contrib. €

0

Partnership

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 Bio-ICD project word cloud

Explore the words cloud of the Bio-ICD project. It provides you a very rough idea of what is the project "Bio-ICD" about.

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Project "Bio-ICD" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙485˙028 €
 EC max contribution 1˙485˙028 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 1˙485˙028.00

Map

 Project objective

Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins. To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats. This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distinctively innovative therapeutic rationales in which a diseased organ begets its own remedy, e.g. a Biologically-Integrated Cardiac Defibrillator (Bio-ICD).

 Publications

year authors and title journal last update
List of publications.
2018 Iolanda Feola
Optogenetic investigation of cardiac arrhythmia mechanisms
published pages: , ISSN: , DOI:
2019-10-03
2019 Emile C. A. Nyns, René H. Poelma, Linda Volkers, Jaap J. Plomp, Cindy I. Bart, Annemarie M. Kip, Thomas J. van Brakel, Katja Zeppenfeld, Martin J. Schalij, Guo Qi Zhang, Antoine A. F. de Vries, Daniël A. Pijnappels
An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation
published pages: eaau6447, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aau6447
Science Translational Medicine 11/481 2019-09-26
2018 Emile C A Nyns, Antoine A F de Vries, Daniël A Pijnappels
Biological defibrillation
published pages: 3915-3917, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy689
European Heart Journal 39/44 2019-06-11
2018 Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov, Daniel A Pijnappels
Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.41076
eLife 7 2019-05-10

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