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Bio-ICD SIGNED

Biological auto-detection and termination of heart rhythm disturbances

Total Cost €

EC-Contrib. €

Partnership

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Bio-ICD project word cloud

Explore the words cloud of the Bio-ICD project. It provides you a very rough idea of what is the project "Bio-ICD" about.

forced innovative detector instead defibrillator resetting generating organ diseased arrhythmias ion probes arrhythmia termination gene transfer screening rationales biologically mechanisms biological expression implantable distinctively malignant tissue detection establishing light traumatizing desired physiological begets data initiation detect electroshock insights hence models icd channels rhythm ventricular longer anti auto suffer disturbances explore life engineering imagine rats yield device cardiac slices acutely proteins purpose rapid rational heart acute optical ones awake terminate remedy hearts painless expressed disturbed self therapeutic safety engineered followed cardioverter effector threatening first computer arrhythmic rat guide cells sensing unexplored electroshocks gated atrial bio pills

Project "Bio-ICD" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙485˙028 €
EC max contribution	1˙485˙028 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	1˙485˙028.00

Map

Project objective

Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins. To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats. This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distinctively innovative therapeutic rationales in which a diseased organ begets its own remedy, e.g. a Biologically-Integrated Cardiac Defibrillator (Bio-ICD).

Publications

List of publications.
year	authors and title	journal	last update
2018	Iolanda Feola Optogenetic investigation of cardiac arrhythmia mechanisms published pages: , ISSN: , DOI:		2019-10-03
2019	Emile C. A. Nyns, RenÃ© H. Poelma, Linda Volkers, Jaap J. Plomp, Cindy I. Bart, Annemarie M. Kip, Thomas J. van Brakel, Katja Zeppenfeld, Martin J. Schalij, Guo Qi Zhang, Antoine A. F. de Vries, DaniÃ«l A. Pijnappels An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation published pages: eaau6447, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aau6447	Science Translational Medicine 11/481	2019-09-26
2018	Emile C A Nyns, Antoine A F de Vries, DaniÃ«l A Pijnappels Biological defibrillation published pages: 3915-3917, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy689	European Heart Journal 39/44	2019-06-11
2018	Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov, Daniel A Pijnappels Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.41076	eLife 7	2019-05-10

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