Opendata, web and dolomites

Bio-ICD SIGNED

Biological auto-detection and termination of heart rhythm disturbances

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Bio-ICD project word cloud

Explore the words cloud of the Bio-ICD project. It provides you a very rough idea of what is the project "Bio-ICD" about.

pills    rational    expression    expressed    tissue    therapeutic    diseased    safety    generating    establishing    ion    anti    bio    termination    unexplored    purpose    arrhythmias    malignant    rapid    innovative    traumatizing    effector    remedy    acutely    physiological    detection    rhythm    instead    yield    cardiac    channels    terminate    electroshocks    rat    atrial    distinctively    detect    guide    detector    slices    insights    models    rats    cardioverter    probes    resetting    desired    biological    auto    electroshock    disturbances    gated    ventricular    device    heart    transfer    gene    followed    sensing    imagine    hearts    life    proteins    initiation    icd    cells    hence    computer    defibrillator    ones    rationales    self    suffer    arrhythmia    biologically    awake    arrhythmic    light    organ    engineering    optical    painless    begets    acute    data    implantable    engineered    forced    screening    threatening    disturbed    explore    first    mechanisms    longer   

Project "Bio-ICD" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙485˙028 €
 EC max contribution 1˙485˙028 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 1˙485˙028.00

Map

 Project objective

Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins. To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats. This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distinctively innovative therapeutic rationales in which a diseased organ begets its own remedy, e.g. a Biologically-Integrated Cardiac Defibrillator (Bio-ICD).

 Publications

year authors and title journal last update
List of publications.
2018 Iolanda Feola
Optogenetic investigation of cardiac arrhythmia mechanisms
published pages: , ISSN: , DOI:
2019-10-03
2019 Emile C. A. Nyns, René H. Poelma, Linda Volkers, Jaap J. Plomp, Cindy I. Bart, Annemarie M. Kip, Thomas J. van Brakel, Katja Zeppenfeld, Martin J. Schalij, Guo Qi Zhang, Antoine A. F. de Vries, Daniël A. Pijnappels
An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation
published pages: eaau6447, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aau6447
Science Translational Medicine 11/481 2019-09-26
2018 Emile C A Nyns, Antoine A F de Vries, Daniël A Pijnappels
Biological defibrillation
published pages: 3915-3917, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy689
European Heart Journal 39/44 2019-06-11
2018 Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov, Daniel A Pijnappels
Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.41076
eLife 7 2019-05-10

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIO-ICD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BIO-ICD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DYMOLAMO (2018)

Dynamic Modeling of Labor Market Mobility and Human Capital Accumulation

Read More  

TOROS (2019)

A Theory-Oriented Real-Time Operating System for Temporally Sound Cyber-Physical Systems

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More