Bio-ICD SIGNED
Biological auto-detection and termination of heart rhythm disturbances
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0Bio-ICD project word cloud
Explore the words cloud of the Bio-ICD project. It provides you a very rough idea of what is the project "Bio-ICD" about.
Project "Bio-ICD" data sheet
The following table provides information about the project.
| Coordinator |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙485˙028 € |
| EC max contribution | 1˙485˙028 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2022-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | coordinator | 1˙485˙028.00 |
Map
Project objective
Imagine a heart that could no longer suffer from life-threatening rhythm disturbances, and not because of pills or traumatizing electroshocks from an Implantable Cardioverter Defibrillator (ICD) device. Instead, this heart has become able to rapidly detect & terminate these malignant arrhythmias fully on its own, after gene transfer. In order to explore this novel concept of biological auto-detection & termination of arrhythmias, I will investigate how forced expression of particular engineered proteins could i) allow cardiac tissue to become a detector of arrhythmias through rapid sensing of acute physiological changes upon their initiation. And how after detection, ii) this cardiac tissue (now as effector), could terminate the arrhythmia by generating a painless electroshock through these proteins. To this purpose, I will first explore the requirements for such detection & termination by studying arrhythmia initiation and termination in rat models of atrial & ventricular arrhythmias using optical probes and light-gated ion channels. These insights will guide computer-based screening of proteins to identify those properties allowing effective arrhythmia detection & termination. These data will be used for rational engineering of the proteins with the desired properties, followed by their forced expression in cardiac cells and slices to assess anti-arrhythmic potential & safety. Promising proteins will be expressed in whole hearts to study their anti-arrhythmic effects and mechanisms, after which the most effective ones will be studied in awake rats. This unexplored concept of self-resetting an acutely disturbed physiological state by establishing a biological detector-effector system may yield unique insight into arrhythmia management. Hence, this could provide distinctively innovative therapeutic rationales in which a diseased organ begets its own remedy, e.g. a Biologically-Integrated Cardiac Defibrillator (Bio-ICD).
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Iolanda Feola Optogenetic investigation of cardiac arrhythmia mechanisms published pages: , ISSN: , DOI: |
2019-10-03 | |
| 2019 |
Emile C. A. Nyns, René H. Poelma, Linda Volkers, Jaap J. Plomp, Cindy I. Bart, Annemarie M. Kip, Thomas J. van Brakel, Katja Zeppenfeld, Martin J. Schalij, Guo Qi Zhang, Antoine A. F. de Vries, Daniël A. Pijnappels An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation published pages: eaau6447, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aau6447 |
Science Translational Medicine 11/481 | 2019-09-26 |
| 2018 |
Emile C A Nyns, Antoine A F de Vries, Daniël A Pijnappels Biological defibrillation published pages: 3915-3917, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy689 |
European Heart Journal 39/44 | 2019-06-11 |
| 2018 |
Rupamanjari Majumder, Iolanda Feola, Alexander S Teplenin, Antoine AF de Vries, Alexander V Panfilov, Daniel A Pijnappels Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.41076 |
eLife 7 | 2019-05-10 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIO-ICD" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "BIO-ICD" are provided by the European Opendata Portal: CORDIS opendata.