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NanoIntra SIGNED

Multitasking Nanoparticles for Intracellular Bioimaging and Biosensing

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoIntra project word cloud

Explore the words cloud of the NanoIntra project. It provides you a very rough idea of what is the project "NanoIntra" about.

nanomaterials    tweezers    nanoparticles    surface    protective    biosensing    objects    proper    nanobiophotonics    photothermally    sers    besides    multitasking    biology    matrix    outcomes    full    designed    nanomedicine    medical    temporal    strategies    particle    first    combined    techniques    position    cancer    materials    tremendous    entitled    optical    constitutes    treatment    toward    purposefully    theranostics    silica    imaging    nano    physics    mystery    economic    cell    dots    nanointra    encapsulated    region    training    insights    diseases    nanocrystals    live    tools    thanks    scattering    structures    lab    characterization    architecture    raman    diagnostic    plasmonic    biotechnology    bright    functional    promises    labeling    multidisciplinary    spread    markers    ultrasensitive    societal    interface    spatial    nanoprobes    hold    cells    chemistry    localized    subcellular    play    enhanced    synthesis    functionalization    biosensors    intracellular    quantum    inside    reveal    manipulate    luminescent    stable   

Project "NanoIntra" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT GENT 

Organization address
address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000
website: http://www.ugent.be

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Belgium [BE]
 Project website https://www.ugent.be/en/research/research-ugent/trackrecord/trackrecord-h2020/msca-h2020/msca-nanointra.htm
 Total cost 258˙530 €
 EC max contribution 258˙530 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 258˙530.00
2    CORNELL UNIVERSITY US (ITHACA NY) partner 0.00

Map

 Project objective

The development of specifically designed nanomaterials for advanced medical applications such as theranostics has become a major technical challenge with great potential societal and economic outcomes. Nanomedicine and related techniques hold great promises for improved diagnostic and treatment of widely spread diseases such as cancer. This project, entitled NanoIntra, aims at developing novel multitasking nanoparticles as advanced tools for highly localized and ultrasensitive intracellular imaging and biosensing. These nanoprobes should provide new insights in the spatial and temporal processes at play in live cells and therefore reveal part of their mystery. Such functional objects are achieved through the design of a complex architecture which involves quantum dots as bright and stable luminescent markers encapsulated in a protective silica matrix. These nanoparticles are combined with plasmonic nanocrystals, which offer new strategies for their photothermally induced intracellular delivery. The targeting and imaging of specific subcellular structures is then achieved thanks to proper surface functionalization of the nanoparticles. In addition, the plasmonic nanocrystals also allow these nanoparticles to be used as Surface Enhanced Raman Scattering (SERS) biosensors. Finally, for a higher control on the use of such nano-biosensors, optical tweezers are used to purposefully manipulate and position the nanoparticles inside the cells at the region of interest. Besides their application in cell labeling and biosensing, these functional nanoparticles have tremendous potential applications in the fields of theranostics, nanomedicine and nanobiophotonics, and NanoIntra constitutes a first step toward the development of a full lab-on-a-particle. Thus, through the synthesis and characterization of novel materials and their application to biotechnology, NanoIntra is a multidisciplinary research and training project at the interface between physics, chemistry and biology.

 Publications

year authors and title journal last update
List of publications.
2018 Kai Ma, Katherine A. Spoth, Ying Cong, Duhan Zhang, Tangi Aubert, Melik Z. Turker, Lena F. Kourkoutis, Eduardo Mendes, Ulrich Wiesner
Early Formation Pathways of Surfactant Micelle Directed Ultrasmall Silica Ring and Cage Structures
published pages: 17343-17348, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08802
Journal of the American Chemical Society 140/50 2020-02-25
2018 Teresa Kao, Ferdinand Kohle, Kai Ma, Tangi Aubert, Alexander Andrievsky, Ulrich Wiesner
Fluorescent Silica Nanoparticles with Well-Separated Intensity Distributions from Batch Reactions
published pages: 1305-1310, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04978
Nano Letters 18/2 2020-02-25
2018 Suzanne Bisschop, Pieter Geiregat, Tangi Aubert, Zeger Hens
The Impact of Core/Shell Sizes on the Optical Gain Characteristics of CdSe/CdS Quantum Dots
published pages: 9011-9021, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b02493
ACS Nano 12/9 2020-02-25
2018 Kai Ma, Yunye Gong, Tangi Aubert, Melik Z. Turker, Teresa Kao, Peter C. Doerschuk, Ulrich Wiesner
Self-assembly of highly symmetrical, ultrasmall inorganic cages directed by surfactant micelles
published pages: 577-580, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0221-0
Nature 558/7711 2020-02-25

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The information about "NANOINTRA" are provided by the European Opendata Portal: CORDIS opendata.

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