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CHROCODYLE SIGNED

Chromosomal Condensin Dynamics: From Local Loading to Global Architecture

Total Cost €

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EC-Contrib. €

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Partnership

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 CHROCODYLE project word cloud

Explore the words cloud of the CHROCODYLE project. It provides you a very rough idea of what is the project "CHROCODYLE" about.

cell    individualization    extrusion    pronged    representing    shaped    uncover    action    put    distinctive    chromosomal    cycle    roles    bacillus    act    complexes    association    biochemical    structural    stages    model    loading    specificity    repair    apparatus    heart    tractable    combined    segregation    fundamentally    exquisite    antibacterial    gene    chromatids    native    damaged    dna    paths    organization    mechanisms    resonance    fibres    chromatin    nuclear    mechanistic    regulatory    basis    elucidate    certain    paramagnetic    sophisticated    molecular    establishment    time    insights    spindle    hallmark    reaction    pathological    levels    thought    underlying    expression    pairs    division    genome    seq    chip    compacted    prokaryotic    sister    linkers    morphological    smc    efficient    intermediate    crystallography    chromatid    map    acts    biology    reveal    electron    preparation    subtilis    function    conduct    hic    rod    conserved    molecules    striking    loops    implications    bridges    active    play    condensin    elementary    bases    transformations    bacterial    chromosome    first    compounds    protein    subunit   

Project "CHROCODYLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙599 €
 EC max contribution 1˙999˙599 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙999˙599.00

Map

 Project objective

Striking morphological transformations are a hallmark of any cell division cycle. During nuclear division chromatin is compacted into distinctive rod-shaped chromatids in preparation of chromosome segregation by the spindle apparatus. Multi-subunit SMC protein complexes and a large number of regulatory factors are at the heart of this elementary process. SMC complexes also play key roles during other aspects of genome function such as the control of gene expression and the repair of damaged DNA. They are thought to act as chromatin linkers with exquisite specificity for certain pairs of DNA fibres. However, the underlying molecular mechanisms are not understood. Active extrusion of DNA loops by the SMC complex has been proposed to be the mechanistic basis for the establishment of long-range, intra-chromatid DNA bridges. Here, I put forward a multi-pronged research programme that aims to elucidate fundamentally conserved features of SMC protein function and action using the prokaryotic SMC condensin complex in Bacillus subtilis as a tractable model system. We will conduct a combined structural, biochemical and cell biology approach (including crystallography, electron paramagnetic resonance, ChIP-Seq and ‘native’ HiC) to uncover how the SMC complex acts at the higher levels of organization of the bacterial chromosome to promote the efficient individualization of sister DNA molecules. We will reveal the molecular and structural bases for the association between the SMC complex and the bacterial chromosome at different stages of the loading reaction – each representing a crucial intermediate in a sophisticated chromosome organization process. For the first time, we will be able to map the paths of chromosomal DNA through an SMC complex. Our in-depth mechanistic insights will likely have implications for the understanding of various pathological conditions and have the potential to contribute to the development of novel antibacterial compounds.

 Publications

year authors and title journal last update
List of publications.
2019 Roberto Vazquez Nunez, Laura B. Ruiz Avila, Stephan Gruber
Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin
published pages: 209-223.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.05.001
Molecular Cell 75/2 2019-12-16
2019 Young-Min Soh, Iain Finley Davidson, Stefano Zamuner, Jérôme Basquin, Florian Patrick Bock, Michael Taschner, Jan-Willem Veening, Paolo De Los Rios, Jan-Michael Peters, Stephan Gruber
Self-organization of parS centromeres by the ParB CTP hydrolase
published pages: 1129-1133, ISSN: 0036-8075, DOI: 10.1126/science.aay3965
Science 366/6469 2019-12-16
2019 John F Marko, Paolo De Los Rios, Alessandro Barducci, Stephan Gruber
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
published pages: 6956-6972, ISSN: 0305-1048, DOI: 10.1093/nar/gkz497
Nucleic Acids Research 47/13 2019-12-16
2018 Friedhelm Pfeiffer, Maria-Antonia Zamora-Lagos, Martin Blettinger, Assa Yeroslaviz, Andreas Dahl, Stephan Gruber, Bianca H. Habermann
The complete and fully assembled genome sequence of Aeromonas salmonicida subsp. pectinolytica and its comparative analysis with other Aeromonas species: investigation of the mobilome in environmental and pathogenic strains
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-4301-6
BMC Genomics 19/1 2019-02-11
2017 Marie-Laure Diebold-Durand, Hansol Lee, Laura B. Ruiz Avila, Haemin Noh, Ho-Chul Shin, Haeri Im, Florian P. Bock, Frank Bürmann, Alexandre Durand, Alrun Basfeld, Sihyun Ham, Jérôme Basquin, Byung-Ha Oh, Stephan Gruber
Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization
published pages: 334-347.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.06.010
Molecular Cell 67/2 2019-02-11

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