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CHROCODYLE SIGNED

Chromosomal Condensin Dynamics: From Local Loading to Global Architecture

Total Cost €

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EC-Contrib. €

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Partnership

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 CHROCODYLE project word cloud

Explore the words cloud of the CHROCODYLE project. It provides you a very rough idea of what is the project "CHROCODYLE" about.

organization    bacterial    chromosome    chromatid    dna    spindle    biochemical    extrusion    function    hallmark    first    biology    implications    structural    chromatin    certain    reveal    loading    rod    pairs    active    nuclear    chip    action    paths    exquisite    cell    thought    elucidate    intermediate    distinctive    bacillus    sister    repair    compounds    mechanistic    elementary    native    crystallography    preparation    compacted    paramagnetic    shaped    roles    fibres    representing    morphological    fundamentally    tractable    act    association    pronged    individualization    electron    sophisticated    regulatory    apparatus    condensin    transformations    model    resonance    time    linkers    genome    molecules    smc    prokaryotic    bases    antibacterial    establishment    play    chromosomal    put    combined    molecular    subtilis    conserved    protein    seq    basis    efficient    reaction    complexes    chromatids    heart    uncover    bridges    levels    specificity    underlying    damaged    stages    subunit    map    expression    mechanisms    segregation    division    conduct    insights    loops    pathological    hic    cycle    acts    striking    gene   

Project "CHROCODYLE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙599 €
 EC max contribution 1˙999˙599 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙999˙599.00

Map

 Project objective

Striking morphological transformations are a hallmark of any cell division cycle. During nuclear division chromatin is compacted into distinctive rod-shaped chromatids in preparation of chromosome segregation by the spindle apparatus. Multi-subunit SMC protein complexes and a large number of regulatory factors are at the heart of this elementary process. SMC complexes also play key roles during other aspects of genome function such as the control of gene expression and the repair of damaged DNA. They are thought to act as chromatin linkers with exquisite specificity for certain pairs of DNA fibres. However, the underlying molecular mechanisms are not understood. Active extrusion of DNA loops by the SMC complex has been proposed to be the mechanistic basis for the establishment of long-range, intra-chromatid DNA bridges. Here, I put forward a multi-pronged research programme that aims to elucidate fundamentally conserved features of SMC protein function and action using the prokaryotic SMC condensin complex in Bacillus subtilis as a tractable model system. We will conduct a combined structural, biochemical and cell biology approach (including crystallography, electron paramagnetic resonance, ChIP-Seq and ‘native’ HiC) to uncover how the SMC complex acts at the higher levels of organization of the bacterial chromosome to promote the efficient individualization of sister DNA molecules. We will reveal the molecular and structural bases for the association between the SMC complex and the bacterial chromosome at different stages of the loading reaction – each representing a crucial intermediate in a sophisticated chromosome organization process. For the first time, we will be able to map the paths of chromosomal DNA through an SMC complex. Our in-depth mechanistic insights will likely have implications for the understanding of various pathological conditions and have the potential to contribute to the development of novel antibacterial compounds.

 Publications

year authors and title journal last update
List of publications.
2019 Roberto Vazquez Nunez, Laura B. Ruiz Avila, Stephan Gruber
Transient DNA Occupancy of the SMC Interarm Space in Prokaryotic Condensin
published pages: 209-223.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.05.001
Molecular Cell 75/2 2019-12-16
2019 Young-Min Soh, Iain Finley Davidson, Stefano Zamuner, Jérôme Basquin, Florian Patrick Bock, Michael Taschner, Jan-Willem Veening, Paolo De Los Rios, Jan-Michael Peters, Stephan Gruber
Self-organization of parS centromeres by the ParB CTP hydrolase
published pages: 1129-1133, ISSN: 0036-8075, DOI: 10.1126/science.aay3965
Science 366/6469 2019-12-16
2019 John F Marko, Paolo De Los Rios, Alessandro Barducci, Stephan Gruber
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes
published pages: 6956-6972, ISSN: 0305-1048, DOI: 10.1093/nar/gkz497
Nucleic Acids Research 47/13 2019-12-16
2018 Friedhelm Pfeiffer, Maria-Antonia Zamora-Lagos, Martin Blettinger, Assa Yeroslaviz, Andreas Dahl, Stephan Gruber, Bianca H. Habermann
The complete and fully assembled genome sequence of Aeromonas salmonicida subsp. pectinolytica and its comparative analysis with other Aeromonas species: investigation of the mobilome in environmental and pathogenic strains
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-017-4301-6
BMC Genomics 19/1 2019-02-11
2017 Marie-Laure Diebold-Durand, Hansol Lee, Laura B. Ruiz Avila, Haemin Noh, Ho-Chul Shin, Haeri Im, Florian P. Bock, Frank Bürmann, Alexandre Durand, Alrun Basfeld, Sihyun Ham, Jérôme Basquin, Byung-Ha Oh, Stephan Gruber
Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization
published pages: 334-347.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.06.010
Molecular Cell 67/2 2019-02-11

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