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MicroParticleControl SIGNED

Controlled synthesis of particulate matter in microfluidics

Total Cost €


EC-Contrib. €






Project "MicroParticleControl" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙500˙000.00


 Project objective

Despite the many advantages of microchemical systems and their successful applications in chemical engineering research, one major drawback greatly limiting their use is their susceptibility to channel clogging for flows containing particulate matter. Hence, the aim of the proposed research is to overcome the challenge of clogging in microfluidic devices and to design microfluidic systems that can tolerate particulate matter and synthesize solid materials according to their specifications (e.g. size, purity, morphology). To reach this goal, we apply a combined experimental and theoretical approach, in which the experimental results will lead to model development reflecting the particle formation and interaction kinetics and their coupling to the hydrodynamics. The novel concept of the proposal is to devise engineering strategies to handle the particulate matter inside the reactor depending on if the solid material is i) an unwanted and insoluble by-product of a reaction, or ii) the target compound (e.g. nanoparticle synthesis or crystallization of organic molecules). Depending on the case we will design different ultrasound application strategies and introduce nucleation sites to control the location of particle formation within the microchannel. This project will provide fundamental insight into the physico-chemical phenomena that result in particle formation, growth and agglomeration processes in continuous flow microdevices, and will provide a theoretical tool for the prediction of the dynamics of particle-particle, particle-wall and particle-fluid interactions, leading to innovative microreactor designs.


year authors and title journal last update
List of publications.
2016 Simon Kuhn
Simulation of particle formation dynamics and clogging events in microfluidics
published pages: , ISSN: , DOI:
International Conferences on MicroREaction Technology (IMRET) 2019-07-08
2017 Wouter Van Aeken, Khurram Shahzad, Tom Van Gerven, Simon Kuhn
Simulations of Particle-Laden Flows in Microchannels
published pages: , ISSN: , DOI:
2017 AIChE Annual Meeting 2019-07-08
2018 J. Ferreira, F. Castro, F. Rocha, S. Kuhn
Protein crystallization in a droplet-based microfluidic device: Hydrodynamic analysis and study of the phase behaviour
published pages: 232-244, ISSN: 0009-2509, DOI: 10.1016/j.ces.2018.06.066
Chemical Engineering Science 191 2019-07-08
2018 Khurram Shahzad, Wouter Van Aeken, Milad Mottaghi, Vahid Kazemi Kamyab, Simon Kuhn
Aggregation and clogging phenomena of rigid microparticles in microfluidics
published pages: Article number 1, ISSN: 1613-4982, DOI: 10.1007/s10404-018-2124-7
Microfluidics and Nanofluidics 22/9 2019-07-08
2018 Zhengya Dong, Claire Delacour, Simon Kuhn
Managing solids in micro/mini flow reactors by ultrasound
published pages: , ISSN: , DOI:
The 16th Meeting of the European Society of Sonochemistry 2019-05-22
2018 Naghmeh Fatemi, Zhengya Dong, Simon Kuhn
Controlled particle formation in microreactors
published pages: , ISSN: , DOI:
15th International Conference on Micro Reaction Technology 2019-05-22
2018 Joana Maria Pereira Ferreira, Filipa Castro, Fernando Rocha, Simon Kuhn
Hydrodynamics and Mixing Dynamics in Droplet-Based Microfluidics for Protein Crystallization
published pages: , ISSN: , DOI:
8th World Congress on Particle Technology 2019-05-22
2018 Zhengya Dong, Claire Delacour, Simon Kuhn
Managing solids in microreactor by high-frequency ultrasound
published pages: , ISSN: , DOI:
15th International Conference on Micro Reaction Technology 2019-05-22
2018 Joana Maria Pereira Ferreira, Filipa Castro, Fernando Rocha, Simon Kuhn
Droplet-based microfluidic devices for protein crystallization
published pages: , ISSN: , DOI:
17th International Conference on the Crystallization of Biological Macromolecules 2019-05-22
2018 Naghmeh Fatemi, Zhengya Dong, Tom Van Gerven, Simon Kuhn
Microbubbles as Heterogeneous Nucleation Sites for Crystallization in Continuous Microfluidic Devices
published pages: 60-69, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b03183
Langmuir 35/1 2019-04-18
2019 Zhengya Dong, David Fernandez Rivas, Simon Kuhn
Acoustophoretic focusing effects on particle synthesis and clogging in microreactors
published pages: 316-327, ISSN: 1473-0197, DOI: 10.1039/c8lc00675j
Lab on a Chip 19/2 2019-04-18

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