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ComplexAssembly SIGNED

The birth of protein complexes

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EC-Contrib. €

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Partnership

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Project "ComplexAssembly" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙957˙717 €
 EC max contribution 1˙957˙717 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙016˙467.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 941˙250.00

Map

 Project objective

Protein complexes are central to many cellular functions but our knowledge of how cells assemble protein complexes remains very sparse. Biophysical and structural data of assembly intermediates are extremely rare. Particularly in higher eukaryotes, it has become clear that complex assembly by random collision of subunits cannot cope with the spatial and temporal complexity of the intricate architecture of many cellular machines. Here I propose to combine systems biology approaches with in situ structural biology methods to visualize protein complex assembly. I want to investigate experimentally in which order the interfaces of protein complexes are formed and to which extent structures of assembly intermediates resemble those observed in fully assembled complexes. I want develop methods to systematically screen for additional factors involved in assembly pathways. I furthermore want to test the hypothesis that mechanisms must exist in eukaryotes that coordinate local mRNA translation with the ordered formation of protein complex interfaces. I believe that in order to understand assembly pathways, these processes, that so far are often studied autonomously, need to be considered jointly and in a protein complex centric manner. The research proposed here will bridge across these different scientific disciplines. In the long term, a better mechanistic understanding of protein complex assembly and the structural characterization of critical intermediates will be of high relevance for scenarios under which a cell’s protein quality control system has to cope with stress, such as aging and neurodegenerative diseases. It might also facilitate the more efficient industrial production of therapeutically relevant proteins.

 Publications

year authors and title journal last update
List of publications.
2018 Isabelle Becher, Amparo Andrés-Pons, Natalie Romanov, Frank Stein, Maike Schramm, Florence Baudin, Dominic Helm, Nils Kurzawa, André Mateus, Marie-Therese Mackmull, Athanasios Typas, Christoph W. Müller, Peer Bork, Martin Beck, Mikhail M. Savitski
Pervasive Protein Thermal Stability Variation during the Cell Cycle
published pages: 1495-1507.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.03.053
Cell 173/6 2019-10-15
2018 Shyamal Mosalaganti, Jan Kosinski, Sahradha Albert, Miroslava Schaffer, Daniela Strenkert, Patrice A. Salomé, Sabeeha S. Merchant, Jürgen M. Plitzko, Wolfgang Baumeister, Benjamin D. Engel, Martin Beck
In situ architecture of the algal nuclear pore complex
published pages: 1-8, ISSN: 2041-1723, DOI: 10.1038/s41467-018-04739-y
Nature Communications 9/1 2019-10-15

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The information about "COMPLEXASSEMBLY" are provided by the European Opendata Portal: CORDIS opendata.

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