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iMDx SIGNED

Microfiber Electrofluidics for Integrated Molecular Diagnostics

Total Cost €

EC-Contrib. €

Partnership

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iMDx project word cloud

Explore the words cloud of the iMDx project. It provides you a very rough idea of what is the project "iMDx" about.

handling porous translation microfiber acid amplified materials instruments dramatically centralized laboratories sheets rna automated structure detection diseases indirect basically detect mef dna of electrochemical cells nasba hiv time biomedical realizing amplification ebola platform paper 3d measuring specialized diagnosis pricing microelectronics reagents applicability zero portable pcr times almost rpa molecular nucleic accessibility ground fabrication manipulation readily microfluidics textiles sequence inappropriate breaking lpa exist powerful point diagnostic antibody combined outcome bacteria antibiotic skilled proximity lamp amplifications disposable biomolecules proteins electrofluidics broad care storage diagnostics clinical assay ligation rely monolithically techniques integrate broaden resistant samples protein mefs imdx

Project "iMDx" data sheet

The following table provides information about the project.

Coordinator	KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	1˙499˙180 €
EC max contribution	1˙499˙180 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-08-01 to 2022-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙499˙180.00

Map

Project objective

'Diagnosis of an increasing number of diseases (such as HIV, Ebola and antibiotic resistant bacteria) rely on centralized laboratories with specialized instruments and skilled personnel. This type of clinical analysis with long lead times and high cost is inappropriate for point of care diagnostics. Portable, automated, and disposable devices with integrated molecular diagnostics (iMDx), could solve this problem. Such devices, however, basically do not exist today.

This research program will develop materials, methods, and diagnostic techniques to enable portable integrated molecular diagnostics (iMDx) devices, that are disposable (almost zero-cost), and that can detect a broad range of diseases using DNA amplification. To achieve this, we will develop '3D microfiber electrofluidics (MEF)'. MEFs rely on simple and readily available porous sheets including paper, and textiles. Their fabrication is simple, and yet they are very powerful because they can monolithically integrate 3D microfluidics, 3D microelectronics, electrochemical analysis, storage of reagents / biomolecules, as well as handling and manipulation of cells.

We will develop techniques, using the combined capabilities of MEFs, for real-time DNA amplification and electrochemical DNA detection directly from samples. We will use three amplifications techniques for realizing a comprehensive iMDx platform: i) DNA detection, using established and state of the art amplification methods (e.g. PCR, LAMP, RPA). ii) RNA detection, using 'nucleic acid sequence-based amplification' (NASBA). iii) Protein detection, using antibody to DNA translation through 'proximity ligation assay' LPA, and using the detection of the amplified DNA is the indirect measure of proteins.

The outcome of this program has the potential to be ground breaking, and change the structure of measuring, processing, and pricing of biomedical information, and dramatically broaden its accessibility and applicability. '

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The information about "IMDX" are provided by the European Opendata Portal: CORDIS opendata.