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iMDx SIGNED

Microfiber Electrofluidics for Integrated Molecular Diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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 iMDx project word cloud

Explore the words cloud of the iMDx project. It provides you a very rough idea of what is the project "iMDx" about.

diagnostic    assay    ligation    amplification    centralized    broaden    skilled    antibody    resistant    electrochemical    storage    detect    translation    accessibility    almost    inappropriate    fabrication    bacteria    microfiber    sequence    measuring    mef    nucleic    automated    microfluidics    proximity    times    of    structure    techniques    readily    lamp    textiles    realizing    platform    breaking    care    point    electrofluidics    outcome    zero    rpa    molecular    biomedical    powerful    rna    exist    amplified    handling    applicability    manipulation    basically    amplifications    sheets    porous    paper    rely    imdx    broad    3d    diagnostics    samples    diagnosis    ground    time    dna    monolithically    laboratories    clinical    pcr    reagents    integrate    indirect    acid    lpa    protein    disposable    ebola    instruments    microelectronics    diseases    pricing    portable    nasba    dramatically    hiv    proteins    materials    antibiotic    mefs    specialized    combined    biomolecules    detection    cells   

Project "iMDx" data sheet

The following table provides information about the project.

Coordinator
KUNGLIGA TEKNISKA HOEGSKOLAN 

Organization address
address: BRINELLVAGEN 8
city: STOCKHOLM
postcode: 100 44
website: www.kth.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙180 €
 EC max contribution 1˙499˙180 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) coordinator 1˙499˙180.00

Map

 Project objective

'Diagnosis of an increasing number of diseases (such as HIV, Ebola and antibiotic resistant bacteria) rely on centralized laboratories with specialized instruments and skilled personnel. This type of clinical analysis with long lead times and high cost is inappropriate for point of care diagnostics. Portable, automated, and disposable devices with integrated molecular diagnostics (iMDx), could solve this problem. Such devices, however, basically do not exist today.

This research program will develop materials, methods, and diagnostic techniques to enable portable integrated molecular diagnostics (iMDx) devices, that are disposable (almost zero-cost), and that can detect a broad range of diseases using DNA amplification. To achieve this, we will develop '3D microfiber electrofluidics (MEF)'. MEFs rely on simple and readily available porous sheets including paper, and textiles. Their fabrication is simple, and yet they are very powerful because they can monolithically integrate 3D microfluidics, 3D microelectronics, electrochemical analysis, storage of reagents / biomolecules, as well as handling and manipulation of cells.

We will develop techniques, using the combined capabilities of MEFs, for real-time DNA amplification and electrochemical DNA detection directly from samples. We will use three amplifications techniques for realizing a comprehensive iMDx platform: i) DNA detection, using established and state of the art amplification methods (e.g. PCR, LAMP, RPA). ii) RNA detection, using 'nucleic acid sequence-based amplification' (NASBA). iii) Protein detection, using antibody to DNA translation through 'proximity ligation assay' LPA, and using the detection of the amplified DNA is the indirect measure of proteins.

The outcome of this program has the potential to be ground breaking, and change the structure of measuring, processing, and pricing of biomedical information, and dramatically broaden its accessibility and applicability. '

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The information about "IMDX" are provided by the European Opendata Portal: CORDIS opendata.

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