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single-C SIGNED

Automatized Catalysis and Single-Carbon Insertion

Total Cost €

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EC-Contrib. €

0

Partnership

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 single-C project word cloud

Explore the words cloud of the single-C project. It provides you a very rough idea of what is the project "single-C" about.

resemble    co    accelerating    catalysts    retrosynthesis    hydrocarbons    structured    excited    transformation    homogeneous    once    virtually    un    compound    introduce    reactions    carbon    automatized    tools    catalyst    molecules    manipulations    medicines    insertion    raw    photovoltaic    workflow    transferring    molecular    environment    unreactive    reduce    homologations    purpose    assemblies    fundamental    powerful    coming    transfer    solid    valorization    situ    catalytic    asymmetric    rearrangements    single    ligands    innovative    platform    olefins    carbene    transforming    workarounds    chiral    materials    complement    bold    replacing    electronic    logics    basic    pioneer    half    synthesis    arising    expedite    devoid    carbonyls    protect    catalysis    time    technologies    grounds    combinatorial    save    planning    units    functions    organic    portfolio    bio    reagents    exist    skeletal    simplest    organocatalysts    configurations    group   

Project "single-C" data sheet

The following table provides information about the project.

Coordinator
STOCKHOLMS UNIVERSITET 

Organization address
address: UNIVERSITETSVAGEN 10
city: STOCKHOLM
postcode: 10691
website: www.su.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙487˙245 €
 EC max contribution 1˙487˙245 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) coordinator 1˙487˙245.00

Map

 Project objective

This project is aimed at accelerating the synthesis of important organic molecules through key enabling technologies towards automatized catalysis and single-carbon insertion reactions. Transferring the simplest carbon units to organic molecules has the potential to change the way we approach synthesis planning through new asymmetric skeletal homologations and rearrangements of simple raw materials, for which only long workarounds exist now. These methods can reduce to half the manipulations required to access relevant medicines, organocatalysts, ligands, bio-molecular tools and photovoltaic devices. They target unreactive functions to introduce fundamental one-carbon units (CO or C) that are present in virtually any organic compound. New powerful reagents that resemble these basic single-carbon units in excited electronic configurations are to be developed for this purpose. The new catalytic methods needed are based on the solid grounds of carbene-transfer reactions and the recent advances of my group in the development of new homogeneous catalysts. Moreover, a new catalyst platform will be developed to complement our existing portfolio for success in the challenging processes targeted in this proposal. We aim to pioneer a fully automatized workflow for research in catalysis that devoid the synthesis of organic ligands replacing them by combinatorial assemblies built in situ from un-structured simple molecules. The new reactions arising from these new catalysts and reagents will expedite the valorization of raw materials (such as carbonyls, olefins and hydrocarbons) into important chiral molecules in a single transformation. This bold aim is a priority of the European Commission for the coming years as it will save time, protect the environment and reduce cost at once. Thus, these innovative technologies have the potential of transforming the research workflow in homogeneous catalysis and the logics of retrosynthesis of organic molecules at a fundamental level.

 Publications

year authors and title journal last update
List of publications.
2019 Marc Montesinos-Magraner, Matteo Costantini, Rodrigo Ramírez-Contreras, Michael E. Muratore, Magnus J. Johansson, Abraham Mendoza
General Cyclopropane Assembly by Enantioselective Transfer of a Redox-Active Carbene to Aliphatic Olefins
published pages: 5930-5935, ISSN: 1433-7851, DOI: 10.1002/anie.201814123
Angewandte Chemie International Edition 58/18 2020-01-30
2019 Emma Bratt, Samuel Suárez-Pantiga, Magnus J. Johansson, Abraham Mendoza
Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates
published pages: 8844-8847, ISSN: 1359-7345, DOI: 10.1039/c9cc03331a
Chemical Communications 55/60 2020-01-29
2019 Kilian Colas, A. Catarina V. D. dos Santos, Abraham Mendoza
i -Pr 2 NMgCl·LiCl Enables the Synthesis of Ketones by Direct Addition of Grignard Reagents to Carboxylate Anions
published pages: 7908-7913, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02899
Organic Letters 21/19 2020-01-29
2019 Zhunzhun Yu, Abraham Mendoza
Enantioselective Assembly of Congested Cyclopropanes using Redox-Active Aryldiazoacetates
published pages: 7870-7875, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b02615
ACS Catalysis 9/9 2020-01-29
2018 Abraham Mendoza, Kilian Colas
Iterative Synthesis of Pluripotent Thioethers through Controlled Redox Fluctuation of Sulfur
published pages: 1329-1333, ISSN: 0936-5214, DOI: 10.1055/s-0036-1591864
Synlett 29/10 2019-10-08
2018 Marc Montesinos-Magraner, Matteo Costantini, Rodrigo Ramirez-Contreras, Michael E. Muratore, Magnus J. Johansson, Abraham Mendoza
General Cyclopropane Assembly via Enantioselective Redox-Active Carbene Transfer to Aliphatic Olefins
published pages: , ISSN: , DOI: 10.26434/chemrxiv.7436795.v1
ChemRxiv 2019-05-23

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