Explore the words cloud of the single-C project. It provides you a very rough idea of what is the project "single-C" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙487˙245 €|
|EC max contribution||1˙487˙245 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
Take a look of project's partnership.
|1||STOCKHOLMS UNIVERSITET||SE (STOCKHOLM)||coordinator||1˙487˙245.00|
This project is aimed at accelerating the synthesis of important organic molecules through key enabling technologies towards automatized catalysis and single-carbon insertion reactions. Transferring the simplest carbon units to organic molecules has the potential to change the way we approach synthesis planning through new asymmetric skeletal homologations and rearrangements of simple raw materials, for which only long workarounds exist now. These methods can reduce to half the manipulations required to access relevant medicines, organocatalysts, ligands, bio-molecular tools and photovoltaic devices. They target unreactive functions to introduce fundamental one-carbon units (CO or C) that are present in virtually any organic compound. New powerful reagents that resemble these basic single-carbon units in excited electronic configurations are to be developed for this purpose. The new catalytic methods needed are based on the solid grounds of carbene-transfer reactions and the recent advances of my group in the development of new homogeneous catalysts. Moreover, a new catalyst platform will be developed to complement our existing portfolio for success in the challenging processes targeted in this proposal. We aim to pioneer a fully automatized workflow for research in catalysis that devoid the synthesis of organic ligands replacing them by combinatorial assemblies built in situ from un-structured simple molecules. The new reactions arising from these new catalysts and reagents will expedite the valorization of raw materials (such as carbonyls, olefins and hydrocarbons) into important chiral molecules in a single transformation. This bold aim is a priority of the European Commission for the coming years as it will save time, protect the environment and reduce cost at once. Thus, these innovative technologies have the potential of transforming the research workflow in homogeneous catalysis and the logics of retrosynthesis of organic molecules at a fundamental level.
|year||authors and title||journal||last update|
Marc Montesinos-Magraner, Matteo Costantini, Rodrigo RamÃrez-Contreras, Michael E. Muratore, Magnus J. Johansson, Abraham Mendoza
General Cyclopropane Assembly by Enantioselective Transfer of a Redox-Active Carbene to Aliphatic Olefins
published pages: 5930-5935, ISSN: 1433-7851, DOI: 10.1002/anie.201814123
|Angewandte Chemie International Edition 58/18||2020-01-30|
Emma Bratt, Samuel SuÃ¡rez-Pantiga, Magnus J. Johansson, Abraham Mendoza
Mechanism and regioselectivity of the anionic oxidative rearrangement of 1,3-diketones towards all-carbon quaternary carboxylates
published pages: 8844-8847, ISSN: 1359-7345, DOI: 10.1039/c9cc03331a
|Chemical Communications 55/60||2020-01-29|
Kilian Colas, A. Catarina V. D. dos Santos, Abraham Mendoza
i -Pr 2 NMgClÂ·LiCl Enables the Synthesis of Ketones by Direct Addition of Grignard Reagents to Carboxylate Anions
published pages: 7908-7913, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02899
|Organic Letters 21/19||2020-01-29|
Zhunzhun Yu, Abraham Mendoza
Enantioselective Assembly of Congested Cyclopropanes using Redox-Active Aryldiazoacetates
published pages: 7870-7875, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b02615
|ACS Catalysis 9/9||2020-01-29|
Abraham Mendoza, Kilian Colas
Iterative Synthesis of Pluripotent Thioethers through Controlled Redox Fluctuation of Sulfur
published pages: 1329-1333, ISSN: 0936-5214, DOI: 10.1055/s-0036-1591864
Marc Montesinos-Magraner, Matteo Costantini, Rodrigo Ramirez-Contreras, Michael E. Muratore, Magnus J. Johansson, Abraham Mendoza
General Cyclopropane Assembly via Enantioselective Redox-Active Carbene Transfer to Aliphatic Olefins
published pages: , ISSN: , DOI: 10.26434/chemrxiv.7436795.v1
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The information about "SINGLE-C" are provided by the European Opendata Portal: CORDIS opendata.