Opendata, web and dolomites

RESISTANCE SIGNED

Resistance evolution in response to spatially variable pathogen communities

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "RESISTANCE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://allaine.it.helsinki.fi/
 Total cost 1˙999˙995 €
 EC max contribution 1˙999˙995 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 988˙041.00
2    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 1˙011˙953.00

Map

 Project objective

Pathogens are prevalent across all ecosystems. Given the threats imposed by pathogens on their hosts, the ability to resist infection is one key determinant of an individual’s reproductive success and survival. According to theory, resistance evolution is driven by pathogen-imposed selection and constrained by host life-history trade-offs. However, resistance evolution is traditionally studied within the “one host-one pathogen” framework, although it is becoming increasingly clear that a single host individual is exploited by diverse pathogen communities. Unravelling this diversity is the key to understanding selection for resistance, and the key aim of this proposal is to bridge this gap between theory and data. The specific objectives of this proposal are to: i) Assess spatio-temporal variation in pathogen communities and their determinants through community modeling; ii) Quantify the role of host resistance in shaping its pathogen community; iii) Unravel resistance mechanisms that determine pathogen communities by combining experimental and molecular approaches; iv) Quantify immediate and cross-generational fitness consequences that different pathogen communities inflict on their host, and v) Validate the experimental results by assessing how past disease communities have shaped host resistance in natural populations. This ambitious goal is now attainable for the first time because over the past decade my research group has amassed long-term data on hundreds of Plantago lanceolata populations in the Åland Islands, and an extensive genetic sample and seed collection that allow estimating past disease communities and resistance evolution through time. Jointly the objectives of this proposal will provide an unprecedented synthesis of how resistance functions and evolves under realistic pathogen loads, with far reaching implications for both redefining the conceptual framework for resistance evolution and for tackling real-world health and food security problems.

 Publications

year authors and title journal last update
List of publications.
2019 Anssi Karvonen, Jukka Jokela, Anna-Liisa Laine
Importance of Sequence and Timing in Parasite Coinfections
published pages: 109-118, ISSN: 1471-4922, DOI: 10.1016/j.pt.2018.11.007
Trends in Parasitology 35/2 2019-10-03
2019 Elina Numminen, Elise Vaumourin, Steven R. Parratt, Lucie Poulin, Anna-Liisa Laine
Variation and correlations between sexual, asexual and natural enemy resistance life-history traits in a natural plant pathogen population
published pages: , ISSN: 1471-2148, DOI: 10.1186/s12862-019-1468-2
BMC Evolutionary Biology 19/1 2019-10-03
2019 Anna-Liisa Laine, Benoit Barrès, Elina Numminen, Jukka P Siren
Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.47091
eLife 8 2019-10-03
2018 Rachel M. Penczykowski, Steven R. Parratt, Benoit Barrès, Suvi K. Sallinen, Anna-Liisa Laine
Manipulating host resistance structure reveals impact of pathogen dispersal and environmental heterogeneity on epidemics
published pages: , ISSN: 0012-9658, DOI: 10.1002/ecy.2526
Ecology 2019-05-28
2018 Anna-Liisa Laine, Hannu Mäkinen
Life-history correlations change under coinfection leading to higher pathogen load
published pages: 126-133, ISSN: 2056-3744, DOI: 10.1002/evl3.48
Evolution Letters 2/2 2019-05-28
2018 Steven R. Parratt, Anna-Liisa Laine
Pathogen dynamics under both bottom-up host resistance and top-down hyperparasite attack
published pages: 2976-2985, ISSN: 0021-8901, DOI: 10.1111/1365-2664.13185
Journal of Applied Ecology 55/6 2019-05-28
2018 Layla Maria Höckerstedt, Jukka Pekka Siren, Anna-Liisa Laine
Effect of spatial connectivity on host resistance in a highly fragmented natural pathosystem
published pages: 844-852, ISSN: 1010-061X, DOI: 10.1111/jeb.13268
Journal of Evolutionary Biology 31/6 2019-05-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RESISTANCE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RESISTANCE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

TOROS (2019)

A Theory-Oriented Real-Time Operating System for Temporally Sound Cyber-Physical Systems

Read More  

SPA4AstroQIT (2019)

Broadband Quantum-Limited Parametric Amplifier for Astronomy and Quantum Information Technology

Read More