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CHROMONUMBER SIGNED

Chromosome number variations in vivo: probing mechanisms of genesis and elimination

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CHROMONUMBER" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 2˙000˙000.00

Map

 Project objective

How variations in whole chromosome number impact organism homeostasis remains an open question. Variations to the normal euploid genome content are frequently found in healthy animals and are thought to contribute with phenotypic variability in adverse situations. Yet they are also at the basis of several human diseases, including neuro-developmental disorders and cancer. Our preliminary data shows that physiological aneuploidy can be identified in certain cells during development. Moreover, we have observed that when induced through mutations, non-euploid cells are effectively eliminated from the cycling population. A quantitative view of the frequency of non-euploid karyotypes and the mechanisms underlying their genesis is lacking in the literature. Further, the tissue specific responses at play to eliminate non-euploid cells, when induced through mutations are not understood. The objectives of this proposal are to quantitatively assess the occurrence of physiological chromosome number variations gaining insight into mechanisms involved in generating it. Additionally, we will identify the tissue-specific pathways involved in maintaining organism homeostasis through the elimination of non-euploid cells. We will use a novel genetic approach to monitor individual chromosome loss at the level of the entire organism, combine it with quantitative methods and state-of-the art-microscopy, and focus on two model organisms - Drosophila and mouse - during development and adulthood. We predict that the findings resulting from this proposal will significantly impact the fields of cell, developmental and animal physiology, generating novel concepts that will bridge the existing gaps in the field, and expand our understanding of the links between karyotype variations, animal development and disease establishment.

 Publications

year authors and title journal last update
List of publications.
2019 Diana Vargas-Hurtado, Jean-Baptiste Brault, Tristan Piolot, Ludovic Leconte, Nathalie Da Silva, Carole Pennetier, Alexandre Baffet, Véronique Marthiens, Renata Basto
Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development
published pages: 2993-3005.e9, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.07.061
Current Biology 29/18 2020-03-05
2019 Maddalena Nano, Simon Gemble, Anthony Simon, Carole Pennetier, Vincent Fraisier, Veronique Marthiens, Renata Basto
Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells
published pages: 3937-3945.e7, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.09.041
Current Biology 29/22 2020-03-05

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