Opendata, web and dolomites


Unravelling the molecular Basis of epigenetic silencing: what factors define a gene as a Polycomb target?

Total Cost €


EC-Contrib. €






Project "AMBITION" data sheet

The following table provides information about the project.


Organization address
postcode: NR4 7UH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JOHN INNES CENTRE UK (NORWICH) coordinator 183˙454.00


 Project objective

The current lack of mechanistic understanding regarding how Polycomb targets are selected severely limits the potential for epigenetic manipulation in many eukaryotic systems. This proposal therefore addresses a key central question in chromatin biology: which factors specify a gene for Polycomb mediated silencing? It will make use of the recent identification of a single nucleotide polymorphism within the target gene that blocks cold induced silencing of the Polycomb switching system at FLOWERING LOCUS C (FLC) in Arabidopsis thaliana. At FLC, specific DNA binding proteins (VAL1, VAL2) and their partners interact in a not yet fully understood regulatory network with Polycomb proteins, which consequently convert environmental cues (prolonged cold) into stable epigenetic memory (silencing of the gene) to achieve flowering. I hypothesise that this regulation involves components of the Apoptosis and Splicing Associated Protein (ASAP) complex, the functions of which have been linked to RNA processing and RNA quality control. Thus, these protein interactions directly link DNA sequence specificity with co-transcriptional regulation through to Polycomb mediated epigenetic gene silencing. I aim to demonstrate that multiple cis and trans factors determine Polycomb target selection and that their combined actions synergize to nucleate Polycomb complexes at FLC, and thus switch the gene from an epigenetically active to a silent state. The proposed work will be achieved through interconnected molecular, biochemical and genetic avenues. It will yield novel and comprehensive mechanistic insights into the complexity and plasticity of epigenetic regulation of Polycomb target genes in plants, with broad impact on chromatin research in other organisms.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AMBITION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "AMBITION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

iRhomADAM (2020)

Uncovering the role of the iRhom2-ADAM17 interaction in inflammatory signalling

Read More  

COLEX (2019)

Coopetition and Legislation in the Spanish Netherlands (1598-1665)

Read More