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GENETONE

Genetic dissection of a tonically active neural circuit

Total Cost €

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EC-Contrib. €

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Partnership

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 GENETONE project word cloud

Explore the words cloud of the GENETONE project. It provides you a very rough idea of what is the project "GENETONE" about.

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Project "GENETONE" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country United Kingdom [UK]
 Project website https://www2.mrc-lmb.cam.ac.uk/groups/debono/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 183˙454.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) coordinator 0.00

Map

 Project objective

Understanding how the brain works is a fundamental challenge in biology and a priority of EU research. A subset of brain circuits can signal tonically to encode persistent stimuli. Such circuits are involved in many sensory systems (e.g. vision, hearing) and in homeostatic responses (e.g. temperature, pH, and posture control). How tonic activity is molecularly achieved remains poorly understood. In C. elegans a tonic circuit promotes aggregation behavior and escape from 21% oxygen. At its core this circuit comprises URX oxygen sensors that tonically stimulate RMG interneurons as oxygen approaches 21%, evoking a switch in behavioral state. Each neuron in the circuit can be imaged and selectively modified in vivo - providing a special opportunity to dissect a tonically active circuit. Genetic screens have isolated 74 mutants with behavioral defects linked to URX-RMG tonic activity and that appear to disrupt hitherto unstudied loci. I am currently identifying the genes defective in these mutants, something I expect to achieve by May 2016 when the Fellowship would begin. I propose to combine genetics, neural imaging, optogenetics and biochemistry to characterize these genes’ function. I expect to define groups of gene products that act together. Some will be hitherto uncharacterized in any animal. I propose to collaborate with partners in the host institute and elsewhere to characterize the function of conserved genetic pathways I discover in depth. I will gain added value from learning new approaches (e.g. biochemistry, CLEM, cell-specific RNA Seq) and by extending some of my findings into a vertebrate model. I expect my research to provide general insights into molecular mechanisms by which tonic circuits work, with potential implications for human disease. This project is likely to pioneer new lines of research indispensible to establish an independent research career, will broaden and deepen my technical expertise, and will help me develop new scientific networks.

 Publications

year authors and title journal last update
List of publications.
2018 Yee Lian Chew, Laura J. Grundy, André E. X. Brown, Isabel Beets, William R. Schafer
Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3
published pages: 20170368, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0368
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1758 2019-05-23
2018 Ian G. McLachlan, Isabel Beets, Mario de Bono, Maxwell G. Heiman
A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism
published pages: e1007435, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007435
PLOS Genetics 14/6 2019-05-23

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