Opendata, web and dolomites


Genetic dissection of a tonically active neural circuit

Total Cost €


EC-Contrib. €






 GENETONE project word cloud

Explore the words cloud of the GENETONE project. It provides you a very rough idea of what is the project "GENETONE" about.

act    74    circuits    imaged    genes    works    subset    circuit    fellowship    linked    aggregation    promotes    begin    tonically    temperature    isolated    2016    networks    seq    neuron    switch    independent    poorly    brain    sensory    special    neural    sensors    signal    stimuli    elegans    rmg    function    molecularly    lines    active    scientific    hearing    genetics    am    disease    posture    behavioral    evoking    added    oxygen    mechanisms    optogenetics    urx    selectively    groups    cell    loci    encode    understanding    mutants    career    defects    biochemistry    vivo    gene    implications    homeostatic    combine    core    imaging    gain    deepen    biology    molecular    persistent    appear    disrupt    vertebrate    uncharacterized    host    hitherto    rna    interneurons    opportunity    vision    conserved    defective    modified    genetic    screens    expertise    discover    stimulate    broaden    ph    unstudied    21    pioneer    dissect    learning    animal    human    model    fundamental    tonic    collaborate    clem    behavior    something    me    insights    escape    indispensible   

Project "GENETONE" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Understanding how the brain works is a fundamental challenge in biology and a priority of EU research. A subset of brain circuits can signal tonically to encode persistent stimuli. Such circuits are involved in many sensory systems (e.g. vision, hearing) and in homeostatic responses (e.g. temperature, pH, and posture control). How tonic activity is molecularly achieved remains poorly understood. In C. elegans a tonic circuit promotes aggregation behavior and escape from 21% oxygen. At its core this circuit comprises URX oxygen sensors that tonically stimulate RMG interneurons as oxygen approaches 21%, evoking a switch in behavioral state. Each neuron in the circuit can be imaged and selectively modified in vivo - providing a special opportunity to dissect a tonically active circuit. Genetic screens have isolated 74 mutants with behavioral defects linked to URX-RMG tonic activity and that appear to disrupt hitherto unstudied loci. I am currently identifying the genes defective in these mutants, something I expect to achieve by May 2016 when the Fellowship would begin. I propose to combine genetics, neural imaging, optogenetics and biochemistry to characterize these genes’ function. I expect to define groups of gene products that act together. Some will be hitherto uncharacterized in any animal. I propose to collaborate with partners in the host institute and elsewhere to characterize the function of conserved genetic pathways I discover in depth. I will gain added value from learning new approaches (e.g. biochemistry, CLEM, cell-specific RNA Seq) and by extending some of my findings into a vertebrate model. I expect my research to provide general insights into molecular mechanisms by which tonic circuits work, with potential implications for human disease. This project is likely to pioneer new lines of research indispensible to establish an independent research career, will broaden and deepen my technical expertise, and will help me develop new scientific networks.


year authors and title journal last update
List of publications.
2018 Yee Lian Chew, Laura J. Grundy, André E. X. Brown, Isabel Beets, William R. Schafer
Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3
published pages: 20170368, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0368
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1758 2019-05-23
2018 Ian G. McLachlan, Isabel Beets, Mario de Bono, Maxwell G. Heiman
A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism
published pages: e1007435, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007435
PLOS Genetics 14/6 2019-05-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENETONE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GENETONE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More